<abstract xmlns="http://www.w3.org/1999/xhtml"><p>With regard to gastric cancer, an important disease and a public health problem, it is expected that understanding the molecular make up of carcinomas will provide us with more precise targets for therapy. Indeed advanced molecular technology has made it possible to classify according to genotype instead of phenotype. For advanced stomach cancer, however, surgery is still the only option for cure. Yet, also after surgery, more than 50% of the patients will die of peritoneal dissemination of their disease. This review looks at the molecular mechanism of peritoneal spread of stomach cancer in order to arrive at a risk profile that enables medical personnel to raise the index of suspicion for peritoneal carcinomatosis. The peritoneal cancer index (PCI) provides a scoring system to measure the extent of peritoneal spread during laparoscopic staging. A recently developed device called the ‘MacSpec pen’ maybe of use to confirm the presence of tumor when there is doubt about the diagnosis. Treatment of peritoneal dissemination consists of cytoreduction, combined with hyperthermic peritoneal chemotherapy (HIPEC).</p></abstract>

With regard to gastric cancer, an important disease and a public health problem, it is expected that understanding the molecular make up of carcinomas will provide us with more precise targets for therapy. Indeed advanced molecular technology has made it possible to classify according to genotype instead of phenotype. For advanced stomach cancer, however, surgery is still the only option for cure. Yet, also after surgery, more than 50% of the patients will die of peritoneal dissemination of their disease. This review looks at the molecular mechanism of peritoneal spread of stomach cancer in order to arrive at a risk profile that enables medical personnel to raise the index of suspicion for peritoneal carcinomatosis. The peritoneal cancer index (PCI) provides a scoring system to measure the extent of peritoneal spread during laparoscopic staging. A recently developed device called the ‘MacSpec pen’ maybe of use to confirm the presence of tumor when there is doubt about the diagnosis. Treatment of peritoneal dissemination consists of cytoreduction, combined with hyperthermic peritoneal chemotherapy (HIPEC).

Risk of peritoneal dissemination in stomach cancer

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Risk of peritoneal dissemination in stomach cancer"}

With regard to gastric cancer, an important disease and a public health problem, it is expected that understanding the molecular make up of carcinomas will...

Risk of peritoneal dissemination in stomach cancer

Published Online: Mar 09, 2018

Page range: 184 - 186

Received: Sep 27, 2017

Accepted: Dec 29, 2017

DOI: https://doi.org/10.1515/cipms-2017-0034

Keywords
gastric cancer, peritoneal dissemination, biomarkers, risk profile, immunohistochemistry

© 2017 Robert Sitarz et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Risk of peritoneal dissemination in stomach cancer

Published Online: Mar 09, 2018

Page range: 184 - 186

Received: Sep 27, 2017

Accepted: Dec 29, 2017

DOI: https://doi.org/10.1515/cipms-2017-0034

Keywordsgastric cancer, peritoneal dissemination, biomarkers, risk profile, immunohistochemistry

© 2017 Robert Sitarz et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
gastric cancer, peritoneal dissemination, biomarkers, risk profile, immunohistochemistry