<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The objective of our work is to examine the influence of prolonged administration of an opioid, on the course of the reparative process of a multiple post-injection wound inflicted upon a white rat’s skin, doing so by way of using light microscopy. The studies were carried out on 24 mature white male rats, aged 4.5-7.5 months, with weights of 130-150 g. For histological examination, the skin sections were stained with hematoxylin and eosin. The preparations were studied and photographed at the magnification of ob.х8, ey.x15 and ob.x40, ey.x10. The «Aver Media» computer system was employed for micropreparations photography. The set levels of light microscopy reveal that the administration of an opioid for a 2 week period does not affect the reparative process of a multiple post-injection wound. Moreover, in most wound canals, the formation of a complete regenerate can be seen. However, after 4 weeks of nalbufin administration, the processes of wound healing slowed and were complicated by the formation of microabscesses. After 6 weeks of opioid administration, destructive changes in the skin were detected. These, in turn, led to the incomplete regenerate formation in the multiple postinjection wound. The experimental results, hence, show the negative effect of prolonged administration of opioid on the reparative processes in the skin.</p></abstract>

The objective of our work is to examine the influence of prolonged administration of an opioid, on the course of the reparative process of a multiple post-injection wound inflicted upon a white rat’s skin, doing so by way of using light microscopy. The studies were carried out on 24 mature white male rats, aged 4.5-7.5 months, with weights of 130-150 g. For histological examination, the skin sections were stained with hematoxylin and eosin. The preparations were studied and photographed at the magnification of ob.х8, ey.x15 and ob.x40, ey.x10. The «Aver Media» computer system was employed for micropreparations photography. The set levels of light microscopy reveal that the administration of an opioid for a 2 week period does not affect the reparative process of a multiple post-injection wound. Moreover, in most wound canals, the formation of a complete regenerate can be seen. However, after 4 weeks of nalbufin administration, the processes of wound healing slowed and were complicated by the formation of microabscesses. After 6 weeks of opioid administration, destructive changes in the skin were detected. These, in turn, led to the incomplete regenerate formation in the multiple postinjection wound. The experimental results, hence, show the negative effect of prolonged administration of opioid on the reparative processes in the skin.

The influence of an opioid on the course of reparative processes

Department of General Anatomy, Danylo Halytskyi Lviv National Medical University, Pekarska Street, 69, 79-010 Lviv, Ukraine

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The influence of an opioid on the course of reparative processes"}

The objective of our work is to examine the influence of prolonged administration of an opioid, on the course of the reparative process of a multiple...

The influence of an opioid on the course of reparative processes

Published Online: May 09, 2015

Page range: 46 - 50

Received: Jan 08, 2015

Accepted: Mar 24, 2015

DOI: https://doi.org/10.1515/cipms-2015-0042

Keywords
skin, animal model, reparative process, opioid

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The influence of an opioid on the course of reparative processes

Published Online: May 09, 2015

Page range: 46 - 50

Received: Jan 08, 2015

Accepted: Mar 24, 2015

DOI: https://doi.org/10.1515/cipms-2015-0042

Keywordsskin, animal model, reparative process, opioid

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
skin, animal model, reparative process, opioid