<abstract xmlns="http://www.w3.org/1999/xhtml">The main side effects of the administration of doxorubicin, a widely used anticancer drug, is the generation of a reactive oxygen species (ROS) in normal cells. As a result, redox disorders and secondary oxidative stress are developed. Doxorubicin ROS generation is attributed to enzymes that are produced abundantly in hepatocytes. Oxidative stress has been a well-known risk factor of doxorubicin-related toxicity. However, in addition, according to the data collected in the last decade, changes in thyroxin status can propagate ROS generation, and, thus, initiate the doxorubicin hepatic effect. Moreover, both compounds have an impact on the cell metabolism. The aim of the study was to verify the thesis that thyroxin can modulate the effect of doxorubicin with regard to redox status and lipid metabolism disorders. In our work, we determined the ratio of NADP+/ NADPH and NAD+/NADH in liver homogenates, blood ketone bodies and triglycerides in the liver and blood in rats treated with doxorubicin and thyroxin. Our results indicate that thyroxin has an insignificant effect on NAD+/NADH, NADP+/NADPH ratios and on hepatic and blood triglycerides. Moreover, thyroxin administration normalized the level of blood ketone bodies that was disturbed by doxorubicin.</abstract>

The main side effects of the administration of doxorubicin, a widely used anticancer drug, is the generation of a reactive oxygen species (ROS) in normal cells. As a result, redox disorders and secondary oxidative stress are developed. Doxorubicin ROS generation is attributed to enzymes that are produced abundantly in hepatocytes. Oxidative stress has been a well-known risk factor of doxorubicin-related toxicity. However, in addition, according to the data collected in the last decade, changes in thyroxin status can propagate ROS generation, and, thus, initiate the doxorubicin hepatic effect. Moreover, both compounds have an impact on the cell metabolism. The aim of the study was to verify the thesis that thyroxin can modulate the effect of doxorubicin with regard to redox status and lipid metabolism disorders. In our work, we determined the ratio of NADP+/ NADPH and NAD+/NADH in liver homogenates, blood ketone bodies and triglycerides in the liver and blood in rats treated with doxorubicin and thyroxin. Our results indicate that thyroxin has an insignificant effect on NAD+/NADH, NADP+/NADPH ratios and on hepatic and blood triglycerides. Moreover, thyroxin administration normalized the level of blood ketone bodies that was disturbed by doxorubicin.

The effect of thyroxin on hepatic redox equilibrium and lipid metabolism in rats treated with doxorubicin

Independent Medical Biology Unit, Medical University of Lublin, Jaczewskiego 8, 20-950 Lublin, Poland

Department of Pneumology, Oncology and Alergology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland

Department of Histology and Embryology, Medical University of Lublin, Radziwillowska 11, 20-080 Lublin, Poland

Department of Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland

St. John’s Cancer Center, Jaczewskiego 7, 20-090 Lublin, Poland

Department of Animal Anatomy and Histology, University of Life Sciences, Akademicka 12, 20-950, Lublin, Poland

Chair and Department of Toxicology, Medical University of Lublin, Chodzki 8, 20-093 Lublin, Poland

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The main side effects of the administration of doxorubicin, a widely used anticancer drug, is the generation of a reactive oxygen species (ROS) in normal...

The effect of thyroxin on hepatic redox equilibrium and lipid metabolism in rats treated with doxorubicin

Published Online: Mar 03, 2015

Page range: 220 - 223

Received: Nov 18, 2014

Accepted: Nov 28, 2014

DOI: https://doi.org/10.1515/cipms-2015-0019

Keywords
doxorubicin, thyroxin, liver, redox equilibrium, lipid metabolism

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The effect of thyroxin on hepatic redox equilibrium and lipid metabolism in rats treated with doxorubicin

Published Online: Mar 03, 2015

Page range: 220 - 223

Received: Nov 18, 2014

Accepted: Nov 28, 2014

DOI: https://doi.org/10.1515/cipms-2015-0019

Keywordsdoxorubicin, thyroxin, liver, redox equilibrium, lipid metabolism

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
doxorubicin, thyroxin, liver, redox equilibrium, lipid metabolism