<abstract xmlns="http://www.w3.org/1999/xhtml">Assessment of the impact of pharmaceutical residues on living organisms is very complex subject. Apart from taking into account the toxicity of individual compounds also their presence in mixtures should be taken into account. In this work, attempts were made to assess the ecotoxicity of biologically active substances (with 50 % effective concentration (<italic>EC</italic>50) values growing from fluoxetine (<italic>EC</italic>50 = 4.431 nM) >> gemfibrozil ≈ 17α-ethinylestradiol ≈ ketorolac > indomethacin > theophylline ≈ progesterone > naproxen ≈ trypsin > 2-(2,4,5-trichlorophenoxy)propionic acid > chloramphenicol > acetylsalicylic acid > ibuprofen > ketoprofen > 19-norethindrone to bezafibrate as the least toxic drug among studied ones) to the ISO standardized Ostracodtoxkit FTM bioassay. The Ostracodtoxkit FTM was proven to be very sensitive tool with respect to responding to presence of pharmaceuticals. Results of studies justify the statement that more research is needed in field of assessment of chronic exposure to pharmaceuticals and other newly emerging pollutants especially when they are present in complex mixture.</abstract>

Assessment of the impact of pharmaceutical residues on living organisms is very complex subject. Apart from taking into account the toxicity of individual compounds also their presence in mixtures should be taken into account. In this work, attempts were made to assess the ecotoxicity of biologically active substances (with 50 % effective concentration (EC50) values growing from fluoxetine (EC50 = 4.431 nM) >> gemfibrozil ≈ 17α-ethinylestradiol ≈ ketorolac > indomethacin > theophylline ≈ progesterone > naproxen ≈ trypsin > 2-(2,4,5-trichlorophenoxy)propionic acid > chloramphenicol > acetylsalicylic acid > ibuprofen > ketoprofen > 19-norethindrone to bezafibrate as the least toxic drug among studied ones) to the ISO standardized Ostracodtoxkit FTM bioassay. The Ostracodtoxkit FTM was proven to be very sensitive tool with respect to responding to presence of pharmaceuticals. Results of studies justify the statement that more research is needed in field of assessment of chronic exposure to pharmaceuticals and other newly emerging pollutants especially when they are present in complex mixture.

Determination of Toxicological Parameters of Selected Bioactive Organic Chemicals Using the Ostracodtoxkit FTM

Department of Analytical Chemistry, Faculty of Chemistry

Chemistry-Didactics-Ecology-Metrology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Determination of Toxicological Parameters of Selected Bioactive Organic Chemicals Using the Ostracodtoxkit F

Assessment of the impact of pharmaceutical residues on living organisms is very complex subject. Apart from taking into account the toxicity of individual...

Determination of Toxicological Parameters of Selected Bioactive Organic Chemicals Using the Ostracodtoxkit F^TM

Published Online: Jan 25, 2019

Page range: 113 - 126

DOI: https://doi.org/10.1515/cdem-2018-0007

Keywords
bioassays, pharmaceuticals, toxicity, Ostracodtoxkit F

© 2018 Błażej Kudłak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Determination of Toxicological Parameters of Selected Bioactive Organic Chemicals Using the Ostracodtoxkit FTM

Published Online: Jan 25, 2019

Page range: 113 - 126

DOI: https://doi.org/10.1515/cdem-2018-0007

Keywordsbioassays, pharmaceuticals, toxicity, Ostracodtoxkit F

© 2018 Błażej Kudłak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Determination of Toxicological Parameters of Selected Bioactive Organic Chemicals Using the Ostracodtoxkit F^TM

Keywords
bioassays, pharmaceuticals, toxicity, Ostracodtoxkit F