Changes in Synovial Fluid Inflammatory Mediators and Cartilage Biomarkers After Experimental Acute Equine Synovitis

1. Caron J.P, Gandy J.C, Schmidt M., Hauptman J.G., Sordillo L.M.: Influence of corticosteroids on interleukin-1β stimulated equine chondrocyte gene expression. Vet Surg 2013, 42, 231-237.10.1111/j.1532-950X.2012.01025.xSearch in Google Scholar

2. Christgau S, Garnero P., Fledelius C, Moniz C, Ensig M, Gineyts E., Rosenquist C, Qvist P.: Collagen type II C-telopeptide fragments as an index of cartilage degradation. Bone 2001, 29, 209-215.10.1016/S8756-3282(01)00504-XSearch in Google Scholar

3. de Grauw J.C., Brama P.A, Wiemer P., Brommer H., van de Lest C.H., van Weeren P.R.: Cartilage-derived biomarkers and lipid mediators of inflammation in horses with osteochondritis dissecans of the distal intermediate ridge of the tibia. Am J Vet Res 2006, 67, 1156-1162.10.2460/ajvr.67.7.115616817736Search in Google Scholar

4. de Grauw J.C., van de Lest C.H, van Weeren P.R.: Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study. Arthritis Res Ther 2009, 11, R35.10.1186/ar2640268818019272138Search in Google Scholar

5. Hill CL, Hunter D.J, Niu J, Clancy M, Guermazi A, Genant H, Gale D, Grainger A, Conaghan P, Felson D.T.: Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis. Ann Rheum Dis 2007, 66, 1599-1603.10.1136/ard.2006.067470209531817491096Search in Google Scholar

6. Jouglin M, Robert C, Valette J.P, Gavard F, Quintin-Colonna F, Denoix J.M.: Metalloproteinases and tumor necrosis factor-alpha activities in synovial fluids of horses: correlation with articular cartilage alterations. Vet Res 2000, 31, 507-515.10.1051/vetres:2000136Search in Google Scholar

7. Kaspiris A, Khaldi L, Grivas T.B, Vasiliadis E, Kouvaras I, Dagkas S, Chronopoulos E, Papadimitriou E.: Subchondral cyst development and MMP-1 expression during progression of osteoarthritis: an immunohistochemical study. Orthop Traumatol Surg Res 2013, 99, 523-529.10.1016/j.otsr.2013.03.01923809184Search in Google Scholar

8. Kunisch E, Kinne R.W., Alsalameh R.J, Alsalameh S.: Pro-inflammatory IL-1beta and/or TNF-alpha up-regulate matrix metalloproteases-1 and -3 mRNA in chondrocyte subpopulations potentially pathogenic in osteoarthritis: in situ hybridization studies on a single cell level. Int J Rheum Dis 2014. Epub ahead of print.10.1111/1756-185X.1243125291965Search in Google Scholar

9. Lim H, Kim H.P.: Matrix metalloproteinase-13 expression in IL-1β-treated chondrocytes by activation of the p38 MAPK/c-Fos/AP-1 and JAK/STAT pathways. Arch Pharm Res 2011, 34, 109-117.10.1007/s12272-011-0113-421468922Search in Google Scholar

10. Lindegaard C, Gleerup K.B, Thomsen M.H, Martinussen T, Jacobsen S, Andersen P.H.: Anti-inflammatory effects of intra-articular administration of morphine in horses with experimentally induced synovitis. Am J Vet Res 2010, 71, 69-75.10.2460/ajvr.71.1.6920043783Search in Google Scholar

11. Lohmander L.S, Atley L.M, Pietka T.A, Eyre D.R.: The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. Arthritis Rheum 2003, 48, 3130-3139.10.1002/art.1132614613275Search in Google Scholar

12. Maldonado M, Nam J.: The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. Biomed Res Int 2013, doi: 10.1155/2013/284873.10.1155/2013/284873377124624069595Search in Google Scholar

13. Matyas J.R, Atley L, Ionescu M, Eyre D.R, Poole A.R.: Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis. Arthritis Rheum 2004, 50, 543-552.10.1002/art.2002714872497Search in Google Scholar

14. Mobasheri A.: Osteoarthritis year 2012 in review: biomarkers. Osteoarthritis Cartilage 2012, 20, 1451-1464.10.1016/j.joca.2012.07.00922842200Search in Google Scholar

15. Morton AJ, Campbell N.B, Gayle J.M, Redding W.R, Blikslager A.T.: Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis. Res Vet Sci 2005, 78, 189-192.10.1016/j.rvsc.2004.07.00615563928Search in Google Scholar

16. Oestergaard S., Chouinard L., Doyle N., Smith S.Y., Tankó L.B., Qvist P: Early elevation in circulating levels of C-telopeptides of type II collagen predicts structural damage in articular cartilage in the rodent model of collagen–induced arthritis. Arthritis Rheum 2006, 54, 2886–2890.10.1002/art.2208316947421Search in Google Scholar

17. Petrov R., MacDonald M.H., Tesch A.M., Benton H.P.: Inhibition of adenosine kinase attenuates interleukin-1- and lipopolysaccharide-induced alterations in articular cartilage metabolism. Osteoarthr Cartilage 2005, 13, 250–257.10.1016/j.joca.2004.12.00415727892Search in Google Scholar

18. Ross M.W.: The lameness score: quantification of lameness severity. In: Diagnosis and Management of Lameness in the Horse. Edited by Ross M.W., Dyson S.J., Philadelphia: W.B. Saunders, 2003, pp. 66–67.Search in Google Scholar

19. Ross T.N., Kisiday J.D., Hess T., McIlwraith C.W.: Evaluation of the inflammatory response in experimentally induced synovitis in the horse: a comparison of recombinant equine interleukin 1 beta and lipopolysaccharide. Osteoarthritis Cartilage 2012, 20, 1583–1590.10.1016/j.joca.2012.08.00822917743Search in Google Scholar

20. Scanzello C.R., Goldring S.R.: The role of synovitis in osteoarthritis pathogenesis. Bone 2012, 51, 249–257.10.1016/j.bone.2012.02.012337267522387238Search in Google Scholar

21. Sellam J., Berenbaum F.: The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol 2010, 6, 625–635.10.1038/nrrheum.2010.15920924410Search in Google Scholar

22. Tchetina E.V, Di Battista J.A., Zukor D.J, Antoniou J, Poole A.R.: Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy. Arthritis Res Ther. 2007, 9, R75.Search in Google Scholar

23. Todhunter P.G, Kincaid S.A., Todhunter R.J, Kammermann J.R, Johnstone B., Baird A.N, Hanson R.R, Wright J.M., Lin H.C, Purohit R.C.: Immunohistochemical analysis of an equine model of synovitis-induced arthritis. Am J Vet Res 1996, 57, 1080-1093.Search in Google Scholar

24. Trumble T.N, Brown M.P, Merritt K.A., Billinghurst R.C.: CTX II (Cartilaps) assay using equine synovial fluid. Osteoarthr Cartilage 2006, 14, 70-71.10.1016/S1063-4584(07)60562-7Search in Google Scholar

25. van den Boom R, van de Lest C.H, Bull S, Brama R.A., van Weeren P.R, Barneveld A: Influence of repeated arthrocentesis and exercise on synovial fluid concentrations of nitric oxide, prostaglandin E2 and glycosaminoglycans in healthy equine joints. Equine Vet J 2005, 37, 250-256.10.2746/042516405453074015892235Search in Google Scholar

26. van Loon J.P., de Grauw J.C, van Dierendonck M, Lami J.J, Back W, van Weeren P.R.: Intra-articular opioid analgesia is effective in reducing pain and inflammation in an equine LPS induced synovitis model. Equine Vet J 2010, 42, 412-419.10.1111/j.2042-3306.2010.00077.x20636777Search in Google Scholar