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Association between Osteoprotegerin gene polymorphisms and risk of coronary artery disease: A systematic review and meta-analysis

P Jia
P Jia
, 
N Wu
N Wu
, 
D Jia
D Jia
 and 
Y Sun
Y Sun
   | Dec 29, 2017
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Article Category: Original Article
Published Online: Dec 29, 2017
Page range: 27 - 33
DOI: https://doi.org/10.1515/bjmg-2017-0021
Keywords
© 2017 Jia P, Wu N, Jia D, Sun Y, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Flow diagram of the study selection process.
Flow diagram of the study selection process.

Figure 2

Forest plots for OPG gene polymorphisms and the risk of CAD. (A) Forest plot for G209A polymorphism and the risk of CAD under dominant (AA/AG vs. GG) model. (B) Forest plot for T245G polymorphism and the risk of CAD under dominant (TT/TG vs. GG) model. (C) Forest plot for T950C polymorphism and the risk of CAD under dominant (CC/CT vs. TT) model. (D) Forest plot for G1181C polymorphism and the risk of CAD under dominant (CC/CG vs. GG) model.
Forest plots for OPG gene polymorphisms and the risk of CAD. (A) Forest plot for G209A polymorphism and the risk of CAD under dominant (AA/AG vs. GG) model. (B) Forest plot for T245G polymorphism and the risk of CAD under dominant (TT/TG vs. GG) model. (C) Forest plot for T950C polymorphism and the risk of CAD under dominant (CC/CT vs. TT) model. (D) Forest plot for G1181C polymorphism and the risk of CAD under dominant (CC/CG vs. GG) model.

Figure 3

Sensitivity analysis results. (A) Sensitivity analysis for G209A polymorphism and the risk of CAD under dominant (AA/AG vs. GG) model. (B) Sensitivity analysis for T245G polymorphism and the risk of CAD under dominant (TT/TG vs. GG) model. (C) Sensitivity analysis for T950C polymorphism and the risk of CAD under dominant (CC/CT vs. TT) model. (D) Sensitivity analysis for G1181C polymorphism and the risk of CAD under dominant (CC/CG vs. GG) model.
Sensitivity analysis results. (A) Sensitivity analysis for G209A polymorphism and the risk of CAD under dominant (AA/AG vs. GG) model. (B) Sensitivity analysis for T245G polymorphism and the risk of CAD under dominant (TT/TG vs. GG) model. (C) Sensitivity analysis for T950C polymorphism and the risk of CAD under dominant (CC/CT vs. TT) model. (D) Sensitivity analysis for G1181C polymorphism and the risk of CAD under dominant (CC/CG vs. GG) model.

Figure 4

Evaluation for publication bias. (A) Funnel plot for G209A polymorphism and the risk of CAD under dominant (AA/AG vs. GG) model. (B) Funnel plot for T245G polymorphism and the risk of CAD under dominant (TT/TG vs. GG) model. (C) Funnel plot for T950C polymorphism and the risk of CAD under dominant (CC/CT vs. TT) model. (D) Funnel plot for G1181C polymorphism and the risk of CAD under dominant (CC/CG vs. GG) model.
Evaluation for publication bias. (A) Funnel plot for G209A polymorphism and the risk of CAD under dominant (AA/AG vs. GG) model. (B) Funnel plot for T245G polymorphism and the risk of CAD under dominant (TT/TG vs. GG) model. (C) Funnel plot for T950C polymorphism and the risk of CAD under dominant (CC/CT vs. TT) model. (D) Funnel plot for G1181C polymorphism and the risk of CAD under dominant (CC/CG vs. GG) model.

Main results of the meta-analyses of the pooled odds ratios.

VariableCases/Controls (n)ORb (95% CI) Ph Value
1 vs. 211 vs. 2212 vs. 22(11 or 12) vs. 2211 vs. (12 or 22)
G209A (1=A; 2=G)215/981.128 (0.664-1.916) 0.655aNA0.898 (0.500-1.613) 0.718a1.005 (0.564-1.792) 0.986aNA
T245G (1=T; 2=G)393/4100.940 (0.678-1.302) 0.708a0.679 (0.236-1.957) 0.474a0.628 (0.209-1.886) 0.407a0.664 (0.247-1.785) 0.417a0.979 (0.682-1.405) 0.909a
T950C (1=C; 2=T)1137/10241.264 (1.108-1.442) 0.000a1.615 (1.242-2.100) 0.000a1.227 (0.994-1.515) 0.057a1.327 (1.090-1.617) 0.005a1.376 (1.097-1.726) 0.006a
G1181C (1=C; 2=G)1105/9061.203 (0.957-1.514) 0.1141.139 (0.677-1.917) 0.6231.243 (1.027-1.504) 0.026a1.268 (1.064-1.511) 0.008a1.227 (0.943-1.595) 0.127a

Main characteristics of studies included in the meta-analyses.

Studies [references][15][14][19][12][13][16]
CountryPolandChinaChinaGermanyJapanChina
EthnicityCaucasianAsianAsianCaucasianAsianAsian
Number (case/control)31/30184/68178/312522/468405/126222/146
Age, year (case/control)65.6/70.562.6/60.7958.3/57.2NA63.0/59.070.1/63.7
Male% (case/control)0.0/0.079.3/57.464.0/62.5100.0/100.0NA72.5/59.6
Hypertension% (case/control)NANA68.5/56.7NA63.0/51.077.0/65.8
Study typecase-controlcase-controlcase-controlcase-controlcase-controlcase-control
Primary outcomeCADACSCADCADCADCAD
Genotyping methodPCR-RFLPSanger sequencingPCR-RFLPPCR-RFLPPCR-RFLPPCR-RFLP
NOS score999999
HWE test (control)yesyesyesyesyesyes
eISSN:
1311-0160
Language:
English
Publication timeframe:
2 times per year
Journal Subjects:
Medicine, Basic Medical Science, other
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