<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Diabetic nephropathy (DN) is the leading cause of endstage renal disease (ESRD) in developed countries. Several environmental and genetic factors predict the development and progression of DN. The renin-angiotensin system was demonstrated to be involved in the development of DN. We evaluated the association between rs4340 of the angiotensin-converting enzyme (<italic>ACE</italic>) gene and DN in Caucasians with type 2 diabetes mellitus (T2DM) in 276 Slovenian patients with T2DM who had DN, and 375 patients without clinical signs of DN. Genetic analysis was performed with either standard polymerase chain reaction (PCR) (for rs4340). Results were analyzed using the χ<sup>2</sup> test and multivariate logistic regression analyses. We found no association between rs4340 and DN. Cystatin C was significantly higher in the DN+ group (<italic>p</italic> &lt;0.001) than in the DN group. Cystatin C was a better marker for the estimation of renal function than estimated glomerular filtration rate (eGFR) according to the modification diet in renal disease (MDRD) equation mL/ min. We concluded that there was no association between the rs4340 of the <italic>ACE</italic> gene and DN in Caucasian patients who have T2DM.</p></abstract>

Diabetic nephropathy (DN) is the leading cause of endstage renal disease (ESRD) in developed countries. Several environmental and genetic factors predict the development and progression of DN. The renin-angiotensin system was demonstrated to be involved in the development of DN. We evaluated the association between rs4340 of the angiotensin-converting enzyme (ACE) gene and DN in Caucasians with type 2 diabetes mellitus (T2DM) in 276 Slovenian patients with T2DM who had DN, and 375 patients without clinical signs of DN. Genetic analysis was performed with either standard polymerase chain reaction (PCR) (for rs4340). Results were analyzed using the χ2 test and multivariate logistic regression analyses. We found no association between rs4340 and DN. Cystatin C was significantly higher in the DN+ group (p <0.001) than in the DN group. Cystatin C was a better marker for the estimation of renal function than estimated glomerular filtration rate (eGFR) according to the modification diet in renal disease (MDRD) equation mL/ min. We concluded that there was no association between the rs4340 of the ACE gene and DN in Caucasian patients who have T2DM.

Polymorphism of angiotensin-converting enzyme (rs4340) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus

Department of Endocrinology and Diabetology

Balkan Journal of Medical Genetics

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Diabetic nephropathy (DN) is the leading cause of endstage renal disease (ESRD) in developed countries. Several environmental and genetic factors predict the...

Polymorphism of angiotensin-converting enzyme (rs4340) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus

Article Category: Original Article

Published Online: Dec 31, 2016

Page range: 29 - 34

DOI: https://doi.org/10.1515/bjmg-2016-0033

Keywords
Angiotensin-converting enzyme (ACE), Diabetic nephropathy, Insertion/deletion (I/D) gene polymorphism, Type 2 diabetes mellitus (T2DM)

© 2016 Šeruga M, Makuc J, Završnik M, Cilenšek I, Ekart R, Petrovič D

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Polymorphism of angiotensin-converting enzyme (rs4340) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus

Article Category: Original Article

Published Online: Dec 31, 2016

Page range: 29 - 34

DOI: https://doi.org/10.1515/bjmg-2016-0033

KeywordsAngiotensin-converting enzyme (ACE), Diabetic nephropathy, Insertion/deletion (I/D) gene polymorphism, Type 2 diabetes mellitus (T2DM)

© 2016 Šeruga M, Makuc J, Završnik M, Cilenšek I, Ekart R, Petrovič D

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords
Angiotensin-converting enzyme (ACE), Diabetic nephropathy, Insertion/deletion (I/D) gene polymorphism, Type 2 diabetes mellitus (T2DM)