Frequency and association of 1691 (G>A) FVL, 20210 (G>A) PT and 677 (C>T) MTHFR with deep vein thrombosis in the population of Bosnia and Herzegovina
, , , and | Aug 02, 2016
About this article
Article Category: Original Article
Published Online: Aug 02, 2016
Page range: 43 - 50
DOI: https://doi.org/10.1515/bjmg-2016-0006
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© 2016 Walter de Gruyter GmbH, Berlin/Boston
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The Frequencies of combined genotypes of 1691 (G>A) FVL, 20210 (G>A) PT and 677 (C>T) MTHFR.
| Combined Genotypes | Patients | Controls |
|---|---|---|
| 1691 (G>A) FVL (GG) and 20210 (G>A) PT (GG) | 85 (98.84) | 199 (100.00) |
| 1691 (G>A) FVL (GG) and 677 (C>T) MTHFR (CC) | 34 (72.34) | 90 (92.78) |
| 1691 (G>A) FVL (AA) and 677 (C>T) MTHFR (CT) | 2 (4.25) | 0 (0.00) |
| 20210 (G>A) PT (GG) and 677 (C>T) MTHFR (CC) | 43 (97.72) | 91 (100.00) |
Allele and genotype frequencies of the 1691 (G>A) FVL, 20210 (G>A) PT and 677 (C>T) MTHFR mutations.
| Mutations | Alleles | Cases | Controls | OR For wild-type | |
|---|---|---|---|---|---|
| 1691 (G>A) FVL | wild type G/G | 88 (79.30) | 199 (96.14) | 6.0 (2.62-14.4) | 0.0001 |
| allele G | 196 (89.50) | 406 (98.06) | 5.6 (2.4-12.7) | 0.0001 | |
| 20210 (G>A) PT | wild type G/G | 108 (97.30) | 207 (100.00) | 13.5 (0.6-263.9) | 0.087 |
| allele G | 219 (98.64) | 414 (100.00) | 13.5 (0.6-263.9) | 0.087 | |
| 677 (C>T) MTHFR | wild type C/C | 43 (38.74) | 91 (43.96) | 1.24 (0.77-1.98) | 0.368 |
| allele C | 133 (66.16) | 274 (70.26) | 0.82 (0.57-1.19) | 0.309 |
Allele and genotype frequencies of factor 1691 (G>A) FVL, 20210 (G>A) PT and 677 (C>T) MTHFR mutations according to gender.
| Mutations | Alleles | Patients | Controls | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Men | Women | χ2 (df = 1) For wild-type | Men | Women | χ2 (df = 1) For wild-type | ||||
| 1691 (G>A) FVL | wild type G/G | 38 (73.08) | 46 (77.96) | 0.359 | 0.549 | 97 (95.10) | 102 (97.14) | 0.582 | 0.445 |
| allele G | 89 (86.40) | 103 (88.80) | 0.287 | 0.592 | 199 (97.54) | 226 (98.26) | 0.771 | 0.387 | |
| 20210 (G>A) PT | wild type G/G | 51 (98.07) | 57 (96.32) | 0.226 | 0.634 | 102 (100.00) | 105 (100.00) | – | – |
| allele G | 103 (99.03) | 116 (98.30) | 0.223 | 0.636 | 204 (100.00) | 210 (100.00) | – | – | |
| 677 (C>T) MTHFR | wild type C/C | 18 (34.61) | 25 (42.37) | 0.701 | 0.402 | 42 (41.18) | 49 (46.67) | 0.873 | 0.350 |
| allele C | 61 (64.21) | 72 (67.92) | 0.165 | 0.680 | 133 (68.91) | 141 (71.94) | 0.428 | 0.512 | |