<abstract xmlns="http://www.w3.org/1999/xhtml"> Hepatic lesions induced by drugs include extremely diverse various clinical, biological and histological manifestations that can determine acute or chronic hepatobiliary disease. The term of hepatitis is recommended to be used when there is a histological confirmation. In the last decades a 11 time increase of the hepatic lesions induced by drugs is reported, due both to the increase of the number of used drugs but also by their more frequent recognition.We carried out a combined retrospective study and longitudinally prospective study that included patients with drug hepatitis. In our study there were 83 cases of drug hepatitis at AINS, which represents 33.46 % of the total number of 248 patients with drug hepatitis. In our study the highest drug hepatitis at AINS were Nimesulid (24 cases), followed by Diclofenac (21 cases), and the fewest at Piroxicam (9 cases). All the cases from the study were symptomatic, showing the increase of the cytolysis enzymes and sometimes cholestasis enzymes (mainly GGT).The average age at diagnosis was 60.1 years for the 248 patients, being lower for the male gender (57.47 years), compared to the female gender (61.26 years). Women were affected in the highest degree, 69.35% being women and 30.64% men. In our study drug hepatitis by hepatic cytolysis was dominant, more frequent than the cholestatic ones.</abstract>

Hepatic lesions induced by drugs include extremely diverse various clinical, biological and histological manifestations that can determine acute or chronic hepatobiliary disease. The term of hepatitis is recommended to be used when there is a histological confirmation. In the last decades a 11 time increase of the hepatic lesions induced by drugs is reported, due both to the increase of the number of used drugs but also by their more frequent recognition.We carried out a combined retrospective study and longitudinally prospective study that included patients with drug hepatitis. In our study there were 83 cases of drug hepatitis at AINS, which represents 33.46 % of the total number of 248 patients with drug hepatitis. In our study the highest drug hepatitis at AINS were Nimesulid (24 cases), followed by Diclofenac (21 cases), and the fewest at Piroxicam (9 cases). All the cases from the study were symptomatic, showing the increase of the cytolysis enzymes and sometimes cholestasis enzymes (mainly GGT).The average age at diagnosis was 60.1 years for the 248 patients, being lower for the male gender (57.47 years), compared to the female gender (61.26 years). Women were affected in the highest degree, 69.35% being women and 30.64% men. In our study drug hepatitis by hepatic cytolysis was dominant, more frequent than the cholestatic ones.

Drug Hepatitis At AINS

University “Ovidius” of Constanta, Faculty of Medicine,

Faculty of Medicine, Constanta, Romania 1st University Alee, Camp B,

ARS Medica Tomitana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Drug Hepatitis At AINS"}

Hepatic lesions induced by drugs include extremely diverse various clinical, biological and histological manifestations that can determine acute or chronic...

Drug Hepatitis At AINS

Published Online: Apr 22, 2017

Page range: 29 - 32

DOI: https://doi.org/10.1515/arsm-2017-0006

Keywords
drug hepatitis, non steroid anti-inflammatory drugs, liver

© by Angelica Nela Stavar

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Drug Hepatitis At AINS

Published Online: Apr 22, 2017

Page range: 29 - 32

DOI: https://doi.org/10.1515/arsm-2017-0006

Keywordsdrug hepatitis, non steroid anti-inflammatory drugs, liver

© by Angelica Nela Stavar

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
drug hepatitis, non steroid anti-inflammatory drugs, liver