<abstract xmlns="http://www.w3.org/1999/xhtml"> Introduction Cushing’s disease is a complex endocrine disorder characterized by excessive glucocorticoid secretion caused by an ACTH-secreting pituitary adenoma. Hyperandrogenism and menstrual disorders such as amenorrhea and oligomenorrhea complete the clinical picture of Cushing’s syndrome. Infertility is relatively common, involving complex pathogenetic mechanisms, which differ depending on the cause of hypercortisolism. Case presentation We present the case of a female patient diagnosed with Cushing’s disease during the investigations carried out to assess infertility. After transsphenoidal adenomectomy, the patient underwent treatment with pasireotide and dopamine agonists, achieving normalization of gonadotropin and estradiol levels. Conclusion Current guidelines recommended transsphenoidal adenomectomy as first-line therapy in an attempt to correct hypercortisolism and restore fertility in patients with Cushing’s disease. In case of relapse pasireotide and dopamine agonists can be effective in normalizing the hormonal profile</abstract>

Introduction Cushing’s disease is a complex endocrine disorder characterized by excessive glucocorticoid secretion caused by an ACTH-secreting pituitary adenoma. Hyperandrogenism and menstrual disorders such as amenorrhea and oligomenorrhea complete the clinical picture of Cushing’s syndrome. Infertility is relatively common, involving complex pathogenetic mechanisms, which differ depending on the cause of hypercortisolism. Case presentation We present the case of a female patient diagnosed with Cushing’s disease during the investigations carried out to assess infertility. After transsphenoidal adenomectomy, the patient underwent treatment with pasireotide and dopamine agonists, achieving normalization of gonadotropin and estradiol levels. Conclusion Current guidelines recommended transsphenoidal adenomectomy as first-line therapy in an attempt to correct hypercortisolism and restore fertility in patients with Cushing’s disease. In case of relapse pasireotide and dopamine agonists can be effective in normalizing the hormonal profile

Infertility as the onset of Cushing’s disease: is pasireotide a treatment option?

Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy & Clinical County Hospital, Cluj-Napoca, Romania

Department of Endocrinology, Cluj-Napoca Clinical County Hospital, Romania

Department of Radiotherapy, Prof. Dr. Ion Chiricuta Oncology Institute, Cluj-Napoca, Romania

Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest & C.I. Parhon National Institute of Endocrinology, Bucharest, Romania

ARS Medica Tomitana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction Cushing’s disease is a complex endocrine disorder characterized by excessive glucocorticoid secretion caused by an ACTH-secreting pituitary...

Infertility as the onset of Cushing’s disease: is pasireotide a treatment option?

Published Online: Aug 25, 2015

Page range: 128 - 131

DOI: https://doi.org/10.1515/arsm-2015-0033

Keywords
Cushing’s disease, pasireotide

© by Ana Valea

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Infertility as the onset of Cushing’s disease: is pasireotide a treatment option?

Published Online: Aug 25, 2015

Page range: 128 - 131

DOI: https://doi.org/10.1515/arsm-2015-0033

KeywordsCushing’s disease, pasireotide

© by Ana Valea

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Cushing’s disease, pasireotide