<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The maintenance of energy homeostasis is achieved with ‘detectors’ that receive signals from the external and internal environment and with multidirectional ‘communication routes’ including neuronal networks and body fluids, such as blood and cerebrospinal fluid. Changes in the energy demands of organisms are caused by current physiological status and environmental conditions, including season and food availability. Little is known about the interactions between the metabolic indicators involved in the maintenance of energy homeostasis, e.g., leptin, orexins and ghrelin. Sheep and other seasonal animals are highly adaptable to their environments because of the plasticity of their neural and endocrine systems. Sheep exhibit leptin resistance and are thus an extremely interesting model for research on the relationship between hormonal indicators of energy metabolism. The paper is focused mainly on the anatomical and functional communication between leptin, ghrelin and orexins, which play principal roles in the adaptation of energetic demands to environmental fluctuations.</p></abstract>

The maintenance of energy homeostasis is achieved with ‘detectors’ that receive signals from the external and internal environment and with multidirectional ‘communication routes’ including neuronal networks and body fluids, such as blood and cerebrospinal fluid. Changes in the energy demands of organisms are caused by current physiological status and environmental conditions, including season and food availability. Little is known about the interactions between the metabolic indicators involved in the maintenance of energy homeostasis, e.g., leptin, orexins and ghrelin. Sheep and other seasonal animals are highly adaptable to their environments because of the plasticity of their neural and endocrine systems. Sheep exhibit leptin resistance and are thus an extremely interesting model for research on the relationship between hormonal indicators of energy metabolism. The paper is focused mainly on the anatomical and functional communication between leptin, ghrelin and orexins, which play principal roles in the adaptation of energetic demands to environmental fluctuations.

Cross-talk between leptin, ghrelin and orexins in the central nervous system of seasonal animals – a review

Department of Animal Biotechnology, Laboratory of Biotechnology and Genomics, Agricultural University of Krakow, Rędzina 1B, 30-248 Kraków,

Annals of Animal Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The maintenance of energy homeostasis is achieved with ‘detectors’ that receive signals from the external and internal environment and with multidirectional...

Cross-talk between leptin, ghrelin and orexins in the central nervous system of seasonal animals – a review

Article Category: Review

Published Online: Apr 28, 2017

Page range: 337 - 350

Received: Jun 14, 2016

Accepted: Oct 24, 2016

DOI: https://doi.org/10.1515/aoas-2016-0070

Keywords
leptin, ghrelin, orexins, energy homeostasis, sheep, seasonality

© by Katarzyna Kirsz

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Cross-talk between leptin, ghrelin and orexins in the central nervous system of seasonal animals – a review

Article Category: Review

Published Online: Apr 28, 2017

Page range: 337 - 350

Received: Jun 14, 2016

Accepted: Oct 24, 2016

DOI: https://doi.org/10.1515/aoas-2016-0070

Keywordsleptin, ghrelin, orexins, energy homeostasis, sheep, seasonality

© by Katarzyna Kirsz

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
leptin, ghrelin, orexins, energy homeostasis, sheep, seasonality