<abstract xmlns="http://www.w3.org/1999/xhtml"><p> In the present study, we examined the effect of single nucleotide polymorphisms (SNPs) of leptin (LEP), skeletal muscle glycogen synthase (GYS1), myogenic differentiation 1 (MYOD1), and myogenic factor 5 (MYF5) genes on economic trait association in pigs. LEP/HindIII, MYOD1/DdeI, MYF5/FokI, and GYS1/FokI genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) from 466 pigs comprised of Duroc, Landrace and Yorkshire breeds. The LEP/HindIII polymorphism differed significantly with respect to average daily gain (ADG) in Duroc pigs (P&lt;0.05). However, the GYS1/FokI polymorphism was not significantly associated with any trait. The MYOD1/DdeI polymorphism was significantly associated with both ADG and meat percentage (MP) in Duroc pigs, and ADG, backfat thickness (BFT) and feed efficiency (FE) in Landrace pigs, whereas the MYOD1/DdeI polymorphism was not significantly associated with any trait in Yorkshire pigs. In addition, the MYF5/FokI polymorphism revealed a close relationship with ADG in Duroc pigs. In conclusion, we believe that the SNPs within LEP, MYOD1 and MYF5 in certain pig breeds play important roles as potential genetic markers for economic traits of pigs.</p></abstract>

In the present study, we examined the effect of single nucleotide polymorphisms (SNPs) of leptin (LEP), skeletal muscle glycogen synthase (GYS1), myogenic differentiation 1 (MYOD1), and myogenic factor 5 (MYF5) genes on economic trait association in pigs. LEP/HindIII, MYOD1/DdeI, MYF5/FokI, and GYS1/FokI genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) from 466 pigs comprised of Duroc, Landrace and Yorkshire breeds. The LEP/HindIII polymorphism differed significantly with respect to average daily gain (ADG) in Duroc pigs (P<0.05). However, the GYS1/FokI polymorphism was not significantly associated with any trait. The MYOD1/DdeI polymorphism was significantly associated with both ADG and meat percentage (MP) in Duroc pigs, and ADG, backfat thickness (BFT) and feed efficiency (FE) in Landrace pigs, whereas the MYOD1/DdeI polymorphism was not significantly associated with any trait in Yorkshire pigs. In addition, the MYF5/FokI polymorphism revealed a close relationship with ADG in Duroc pigs. In conclusion, we believe that the SNPs within LEP, MYOD1 and MYF5 in certain pig breeds play important roles as potential genetic markers for economic traits of pigs.

Effects of LEP, GYS1, MYOD1, and MYF5 polymorphisms on pig economic traits

National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Republic of Korea

Swine Science and Technology Center, Gyeongnam National University of Science and Technology, Jinju 660-758, Republic of Korea

Department of Animal Resource Technology, Gyeongnam National University of Science and Technology, Jinju 660-758, Republic of Korea

Annals of Animal Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Effects of LEP, GYS1, MYOD1, and MYF5 polymorphisms on pig economic traits"}

In the present study, we examined the effect of single nucleotide polymorphisms (SNPs) of leptin (LEP), skeletal muscle glycogen synthase (GYS1), myogenic...

Effects of LEP, GYS1, MYOD1, and MYF5 polymorphisms on pig economic traits

Article Category: Animal genetics and breeding

Published Online: Jul 29, 2015

Page range: 629 - 640

Received: Sep 26, 2014

Accepted: Feb 12, 2015

DOI: https://doi.org/10.1515/aoas-2015-0022

© by Sam Woong Kim

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.