<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Introduction: In this study, we aimed to investigate the importance of some distinctive morphological parameters in predicting the extrathyroidal extension, as marker of aggressiveness, in a series of papillary thyroid microcarcinoma (PTMC) cases. Material and methods: All consecutive PTMC cases, sized ≥ 5mm, registered at the Department of Pathology, Tîrgu-Mureș Emergency County Hospital from January 2002 to December 2013 were re-evaluated. The following histological features were noted: the multifocality, the extrathyroidal extension, the histologic variant, the tumor’s border (well circumscribed versus infiltrative), the PTC nuclear features (well developed versus subtle), the tumor associated stromal reaction (fibrosis/desmoplasia/sclerosis versus none of these changes), the presence of “plump pink” cells, psammoma bodies, intratumoral lymphocytic infiltrate, cystic change, back-to-back arrangement, intratumoral multinucleated giant cells and lymph node involvement. Results: Our study included 72 PTMC cases, summing up to a total of 80 PTMC foci. We have shown that extrathyroidal extension is significantly associated with the presence of “plump pink”cells (p=0.0019), well developed nuclear features of PTC (p=0.018) and tumor associated stromal reaction (fibrosis/dezmoplazia/sclerosis) (p&lt;0.0001). Other parameters were more prevalent among PTMC foci with extrathyroidal extension, but did not reach statistical significance. Conclusion: Our results pointed out the importance of a distinct set of morphological microscopical parameters, predictive for extrathyroidal extension in PTMC cases (“plump pink” cells, well developed PTC nuclear features, tumor associated stromal reaction, infiltrative tumor borders and conventional PTC histology). All these parameters are important to be mentioned in the histopathological reports, as they might be associated with a more aggressive biological behaviour. </p></abstract>

Introduction: In this study, we aimed to investigate the importance of some distinctive morphological parameters in predicting the extrathyroidal extension, as marker of aggressiveness, in a series of papillary thyroid microcarcinoma (PTMC) cases. Material and methods: All consecutive PTMC cases, sized ≥ 5mm, registered at the Department of Pathology, Tîrgu-Mureș Emergency County Hospital from January 2002 to December 2013 were re-evaluated. The following histological features were noted: the multifocality, the extrathyroidal extension, the histologic variant, the tumor’s border (well circumscribed versus infiltrative), the PTC nuclear features (well developed versus subtle), the tumor associated stromal reaction (fibrosis/desmoplasia/sclerosis versus none of these changes), the presence of “plump pink” cells, psammoma bodies, intratumoral lymphocytic infiltrate, cystic change, back-to-back arrangement, intratumoral multinucleated giant cells and lymph node involvement. Results: Our study included 72 PTMC cases, summing up to a total of 80 PTMC foci. We have shown that extrathyroidal extension is significantly associated with the presence of “plump pink”cells (p=0.0019), well developed nuclear features of PTC (p=0.018) and tumor associated stromal reaction (fibrosis/dezmoplazia/sclerosis) (p<0.0001). Other parameters were more prevalent among PTMC foci with extrathyroidal extension, but did not reach statistical significance. Conclusion: Our results pointed out the importance of a distinct set of morphological microscopical parameters, predictive for extrathyroidal extension in PTMC cases (“plump pink” cells, well developed PTC nuclear features, tumor associated stromal reaction, infiltrative tumor borders and conventional PTC histology). All these parameters are important to be mentioned in the histopathological reports, as they might be associated with a more aggressive biological behaviour.

Distinct Morphological Features Predictive for Aggressiveness of Papillary Thyroid Microcarcinoma: a Study of 72 Cases and 80 Tumor Foci

Departament of Histology, University of Medicine and Pharmacy of TirguMures, Romania

Department of Pathology, University of Medicine and Pharmacy of TirguMures, Romania

Departament of Endocrinology, University of Medicine and Pharmacy of TirguMures, Romania

Department of Pathology, University of Medicine and Pharmacy of Tirgu Mures, Romania

Department of Pathology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, France

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Introduction: In this study, we aimed to investigate the importance of some distinctive morphological parameters in predicting the extrathyroidal extension, as...

Distinct Morphological Features Predictive for Aggressiveness of Papillary Thyroid Microcarcinoma: a Study of 72 Cases and 80 Tumor Foci

Published Online: Feb 09, 2016

Page range: 51 - 55

Received: Aug 13, 2015

Accepted: Sep 03, 2015

DOI: https://doi.org/10.1515/amma-2015-0112

Keywords
thyroid, papillary microcarcinoma, extrathyroidal extension, plump cells

© by Ancuţa Elena Zahan

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Distinct Morphological Features Predictive for Aggressiveness of Papillary Thyroid Microcarcinoma: a Study of 72 Cases and 80 Tumor Foci

Published Online: Feb 09, 2016

Page range: 51 - 55

Received: Aug 13, 2015

Accepted: Sep 03, 2015

DOI: https://doi.org/10.1515/amma-2015-0112

Keywordsthyroid, papillary microcarcinoma, extrathyroidal extension, plump cells

© by Ancuţa Elena Zahan

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
thyroid, papillary microcarcinoma, extrathyroidal extension, plump cells