<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Objective</bold>: Silver complexes of antibacterial quinolones have the potential advantage of combining the antibacterial activity of silver and fluoroquinolones. The objective of our study was the preparation and the preliminary physico-chemical characterization of a silver complex with ofloxacin.<bold>Methods</bold>: To achieve our goals several spectroscopic methods (ultraviolet spectrophotometry, mass spectrometry, and Fourier transform infrared spectroscopy) and thermal methods (differential scanning calorimetry and thermogravimetric analysis) were used in order to elucidate the chemical structure of the complex.<bold>Results</bold>: Using mass spectrometry we established the stoichiometric ratio silver:ofloxacin as 1:2. Experimental data suggest a particular coordination for ofloxacin, as a monodentate ligand, in the formation of a complex with silver, through the nitrogen atom from the methyl-piperazine cycle.<bold>Conclusions</bold>: The obtained complex has a chemical structure likely [Ag(Ofloxacin)2]NO3, requiring evaluation through other physico-chemical methods.</abstract>

Objective: Silver complexes of antibacterial quinolones have the potential advantage of combining the antibacterial activity of silver and fluoroquinolones. The objective of our study was the preparation and the preliminary physico-chemical characterization of a silver complex with ofloxacin.Methods: To achieve our goals several spectroscopic methods (ultraviolet spectrophotometry, mass spectrometry, and Fourier transform infrared spectroscopy) and thermal methods (differential scanning calorimetry and thermogravimetric analysis) were used in order to elucidate the chemical structure of the complex.Results: Using mass spectrometry we established the stoichiometric ratio silver:ofloxacin as 1:2. Experimental data suggest a particular coordination for ofloxacin, as a monodentate ligand, in the formation of a complex with silver, through the nitrogen atom from the methyl-piperazine cycle.Conclusions: The obtained complex has a chemical structure likely [Ag(Ofloxacin)2]NO3, requiring evaluation through other physico-chemical methods.

A New Silver Complex with Ofloxacin – Preliminary Study

University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Department of Pharmaceutical Chemistry

University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, student

University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Department of Analytical Chemistry

University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Department of Physical Chemistry

University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Department of General and Inorganic Chemistry

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"A New Silver Complex with Ofloxacin \u2013 Preliminary Study"}

Objective: Silver complexes of antibacterial quinolones have the potential advantage of combining the antibacterial activity of silver and fluoroquinolones....

A New Silver Complex with Ofloxacin – Preliminary Study

Published Online: May 20, 2016

Page range: 192 - 198

Received: Jul 23, 2015

Accepted: Sep 03, 2015

DOI: https://doi.org/10.1515/amma-2015-0091

Keywords
fluoroquinolones, ofloxacin, silver, metalcomplex, silver nitrate

© 2016 Rusu Aura et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A New Silver Complex with Ofloxacin – Preliminary Study

Published Online: May 20, 2016

Page range: 192 - 198

Received: Jul 23, 2015

Accepted: Sep 03, 2015

DOI: https://doi.org/10.1515/amma-2015-0091

Keywordsfluoroquinolones, ofloxacin, silver, metalcomplex, silver nitrate

© 2016 Rusu Aura et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
fluoroquinolones, ofloxacin, silver, metalcomplex, silver nitrate