Basic Mechanisms of Action of the Antiepileptic Drugs

1. Bagal SK, Brown AD, Cox PJ et al. Ion channels as therapeutic targets: a drug discovery perspective. J Med Chem 2013;56;3:593-624.10.1021/jm301143323121096Search in Google Scholar

2. Bagal SK, Marron BE, Owen RM, Storer RI, Swain NA. Voltage gated sodium channels as drug discovery targets. Channels 2015;9;6:360-366.10.1080/19336950.2015.1079674485004226646477Search in Google Scholar

3. Benarroch, EE. GABAA receptor heterogeneity, function, and implications for epilepsy. Neurology 2007;68:612-614.10.1212/01.wnl.0000255669.83468.dd17310035Open DOISearch in Google Scholar

4. Beydoun A, D’Souza J, Hebert D, et al. Lacosamide: pharmacology, mechanisms of action and pooled efficacy and safety data in partial-onset seizures. Expert Rev Neurother 2009;9:33-42.10.1586/14737175.9.1.3319102666Search in Google Scholar

5. Bialer M, White HS. Key factors in the discovery and development of new antiepileptic drugs. Nature Reviews Drug Discovery 2010;9:68-82.10.1038/nrd299720043029Open DOISearch in Google Scholar

6. Britton JW, Zakaria TM, Benarroch E. Mechanisms of action of antiepileptic drugs. In: Cascino GD, Sirven JI. Adult Epilepsy. John Wiley & Sons 2011:115-126.10.1002/9780470975039.ch9Search in Google Scholar

7. Catterall WA, Few AP. Calcium channel regulation and presynaptic plasticity. Neuron 2008;59:882-901.10.1016/j.neuron.2008.09.00518817729Search in Google Scholar

8. Corbin-Leftwich A, Mossade SM, Ha J et al. Retigabine holds KV7 channels open and stabilizes the resting potential. J Gen Physiol 2016;147;3:229-241.10.1085/jgp.201511517477237426880756Search in Google Scholar

9. Errington AC, Stohr T, Heers C, Lees G. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Mol Pharmacol 2008;73:157-169.10.1124/mol.107.03986717940193Search in Google Scholar

10. Fattore C, Perucca E. Novel medications for epilepsy. Drugs 2011;71:2151-2178.10.2165/11594640-000000000-0000022035515Search in Google Scholar

11. French JA, Faught E. Rational polytherapy. Epilepsia 2009;50;8:63-68.10.1111/j.1528-1167.2009.02238.x19702736Search in Google Scholar

12. Gao L, Li S. Emerging drugs for partial-onset epilepsy: a review of brivaracetam. Ther Clin Risk Manag 2016;12:719-734.Search in Google Scholar

13. Ghasemi M, Schachter SC. The NMDA receptor complex as a therapeutic target in epilepsy: a review. Epilepsy Behav 2011;22;4:617-640.10.1016/j.yebeh.2011.07.02422056342Open DOISearch in Google Scholar

14. Gunthorpe MJ, Large CH, Sankar R. The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy. Epilepsia 2012;53:412-424.10.1111/j.1528-1167.2011.03365.x22220513Search in Google Scholar

15. Hendrich J, Van Minh AT, Heblich F, Nieto-Rostro M, Watschinger K, Striessnig J, et al. Pharmacological disruption of calcium channel trafficking by the alpha2 delta ligand gabapentin. Proceedings of the National Academy of Sciences of the United States of America 2008;105:3628-3633.10.1073/pnas.0708930105226519518299583Search in Google Scholar

16. Henshall DC, Diaz-Hernandez M, Miras-Portugal MT, Engel T. P2X receptors as targets for the treatment of status epilepticus. Front Cell Neurosci 2013;7:237.10.3389/fncel.2013.00237384079324324404Search in Google Scholar

17. Imbrici P, Camerino DC, Tricarico D. Major channels involved in neuropsychiatric disorders and therapeutic perspectives. Front Genet 2013;4:76.10.3389/fgene.2013.00076364624023675382Search in Google Scholar

18. Jin LJ, Schlesinger F, Song YP, Dengler R, Krampfl K. The interaction of the neuroprotective compounds riluzole and phenobarbital with AMPA-type glutamate receptors: a patchclamp study. Pharmacology 2010;85:54-62.10.1159/00026864120051697Open DOISearch in Google Scholar

19. Khosravani H, Zamponi GW. Voltage-gated calcium channels and idiopathic generalized epilepsies. Physiol Rev 2006;86:941-966.10.1152/physrev.00002.200616816142Open DOISearch in Google Scholar

20. Lee CY, Chen CC, Liou HH. Levetiracetam inhibits glutamate transmission through presynaptic P/Q-type calcium channels on the granule cells of the dentate gyrus. Br J Pharmacol 2009;158:1753-1762.10.1111/j.1476-5381.2009.00463.x280121619888964Search in Google Scholar

21. Löscher W. Valproate: a review of its basic pharmacology after 35 years of clinical use in pharmacotherapy of epilepsy. CNS Drugs 2002;16;10:669-694.10.2165/00023210-200216100-0000312269861Search in Google Scholar

22. Łuszczki JJ. Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions. Pharmacology Reports 2009;61;2:197-216.10.1016/S1734-1140(09)70024-6Search in Google Scholar

23. Mantegazza M, Curia G, Biagini G, et al. Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol 2010;9:413-424.10.1016/S1474-4422(10)70059-4Open DOISearch in Google Scholar

24. Meldrum BS, Rogawski MA. Molecular targets for antiepileptic drug development. Neurotherapeutics: The Journal of the American Society for Experimental Neurotherapeutics 2007;4:18-61.10.1016/j.nurt.2006.11.010185243617199015Search in Google Scholar

25. Miceli F, Soldovieri MV, Ambrosino Pet al. Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits. J Neurosci 2015;35;9:3782-3793.10.1523/JNEUROSCI.4423-14.2015660556725740509Search in Google Scholar

26. Mumoli L, Palleria C, Gasparini S et al. Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures. Drug Des Devel Ther 2015;9:5719-5725.Search in Google Scholar

27. Poolos NP. Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Ion Channelopathy in Epilepsy. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper‘s Basic Mechanisms of the Epilepsies. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US) 2012.10.1093/med/9780199746545.003.0007Search in Google Scholar

28. Porter RJ, Baulac M, Nohria V. Clinical development of drugs for epilepsy: a review of approaches in the United States and Europe. Epilepsy Research 2010;89:163-175.10.1016/j.eplepsyres.2010.02.00520347575Search in Google Scholar

29. Potschka H. Pharmacological treatment strategies: Mechanisms of antiepileptic drugs. Epileptology 2013;1:31-37.10.1016/j.epilep.2012.11.004Search in Google Scholar

30. Rogawski MA, Bazil CW. New Molecular Targets for Antiepileptic Drugs: α2δ, SV2A, and Kv7/KCNQ/M Potassium Channels. Current Neurology and Neuroscience Reports 2008;8;4:345-352.10.1007/s11910-008-0053-7258709118590620Open DOISearch in Google Scholar

31. Schipper S, Aalbers MW, Rijkers K, Swijsen A, Rigo JM, et al. Tonic GABAA Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy. Mol Neurobiol 2016; 53;8:5252-5265.10.1007/s12035-015-9423-8501214526409480Search in Google Scholar

32. Sigel E, Luscher BP. A closer look at the high affinity benzodiazepine binding site on GABAA receptors. Current Topics in Medicinal Chemistry 2011;11:241-246.10.2174/15680261179486356221189125Open DOISearch in Google Scholar

33. Stas JI, Bocksteins E, Jensen CS, Schmitt N, Snyders DJ. The anticonvulsant retigabine suppresses neuronal KV2-mediated currents. Sci Rep 2016;6:350-380.10.1038/srep35080506208427734968Search in Google Scholar

34. Tambucci R, Basti C, Maresca M, Coppola G, Verrotti A. Update on the role of eslicarbazepine acetate in the treatment of partial-onset epilepsy. Neuropsychiatr Dis Treat 2016;12:1251-1260.Search in Google Scholar

35. Tang FR, Bradford, HF, Ling EA. Metabotropic glutamate receptors in the control of neuronal activity and as targets for development of anti-epileptogenic drugs. Curr Med Chem 2009;16:2189-2204.10.2174/09298670978861271019519386Open DOISearch in Google Scholar

36. Wuttke TV, Lerche H. Novel Anticonvulsant Drugs Targeting Voltage-Dependent Ion Channels. Expert Opinion on Investigational Drugs 2006;15:1167-1177.10.1517/13543784.15.10.116716989594Open DOISearch in Google Scholar