<abstract xmlns="http://www.w3.org/1999/xhtml"><p> In this manuscript was investigated behaviour of drug valsartan by micellar media of anionic surfactant sodium dodecyl sulphate. As the method was used electrical conductivity for the determination of critical micelle concentration at different temperatures (T = 293.15 - 313.15 K), as well as calculated thermodynamic parameters like standard Gibbs free energy, enthalpy and entropy of micellization. According to contribution of Gibbs free energy is the process of micellization primarily controlled by entropy. Solubilization of valsartan was studied in surfactant system at 298.15 K and physiological conditions pH 7.4 using UV-spectrophotometry at different concentration range (0.001 - 0.07 mol/l) of sodium dodecyl sulphate. The solubilization of drug was observed with increasing concentration of surfactant in aqueous solution.</p></abstract>

In this manuscript was investigated behaviour of drug valsartan by micellar media of anionic surfactant sodium dodecyl sulphate. As the method was used electrical conductivity for the determination of critical micelle concentration at different temperatures (T = 293.15 - 313.15 K), as well as calculated thermodynamic parameters like standard Gibbs free energy, enthalpy and entropy of micellization. According to contribution of Gibbs free energy is the process of micellization primarily controlled by entropy. Solubilization of valsartan was studied in surfactant system at 298.15 K and physiological conditions pH 7.4 using UV-spectrophotometry at different concentration range (0.001 - 0.07 mol/l) of sodium dodecyl sulphate. The solubilization of drug was observed with increasing concentration of surfactant in aqueous solution.

Influence of Valsartan on the thermodynamics of micellization of anionic surfactant Sodium Dodecyl Sulphate

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

In this manuscript was investigated behaviour of drug valsartan by micellar media of anionic surfactant sodium dodecyl sulphate. As the method was used...

Influence of Valsartan on the thermodynamics of micellization of anionic surfactant Sodium Dodecyl Sulphate

Article Category: Original research article

Published Online: Feb 07, 2017

Page range: 30 - 36

Received: May 26, 2016

Accepted: Nov 03, 2016

DOI: https://doi.org/10.1515/afpuc-2016-0019

Keywords
Valsartan - sodium dodecyl sulphate - critical micelle concentration - micellization - thermodynamics - solubilization

© by L. Stopková

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Influence of Valsartan on the thermodynamics of micellization of anionic surfactant Sodium Dodecyl Sulphate

Article Category: Original research article

Published Online: Feb 07, 2017

Page range: 30 - 36

Received: May 26, 2016

Accepted: Nov 03, 2016

DOI: https://doi.org/10.1515/afpuc-2016-0019

KeywordsValsartan - sodium dodecyl sulphate - critical micelle concentration - micellization - thermodynamics - solubilization

© by L. Stopková

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Valsartan - sodium dodecyl sulphate - critical micelle concentration - micellization - thermodynamics - solubilization