<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The aim of our work was to investigate the effect of amitriptyline, citalopram and venlafaxine on the heart during ischemic- reperfusion (l-R) injury. Amitriptyline prolonged both QRS complex and QTc interval duration; citalopram and venlafaxine prolonged only QTc interval duration. Amitriptyline worked most proarrhythmogenic, citalopram least; venlafaxine increased the heart rate during ischemia; however, prolonged QTc interval at the beginning of reperfusion was followed by serious dysrhythmias. </p></abstract>

The aim of our work was to investigate the effect of amitriptyline, citalopram and venlafaxine on the heart during ischemic- reperfusion (l-R) injury. Amitriptyline prolonged both QRS complex and QTc interval duration; citalopram and venlafaxine prolonged only QTc interval duration. Amitriptyline worked most proarrhythmogenic, citalopram least; venlafaxine increased the heart rate during ischemia; however, prolonged QTc interval at the beginning of reperfusion was followed by serious dysrhythmias.

Changes in electrical activity of heart during ischemic–reperfusion injury modified by the administration of antidepressants

Comenius University in Bratislava, Faculty of Pharmacy, Department of Pharmacology and Toxicology, Bratislava,

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The aim of our work was to investigate the effect of amitriptyline, citalopram and venlafaxine on the heart during ischemic- reperfusion (l-R) injury....

Changes in electrical activity of heart during ischemic–reperfusion injury modified by the administration of antidepressants

Published Online: Nov 23, 2016

Page range: 5 - 8

Received: Jun 19, 2016

Accepted: Aug 18, 2016

DOI: https://doi.org/10.1515/afpuc-2016-0006

Keywords
amitriptylin, citalopram, venlafaxine

© by M. Vicen

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Changes in electrical activity of heart during ischemic–reperfusion injury modified by the administration of antidepressants

Published Online: Nov 23, 2016

Page range: 5 - 8

Received: Jun 19, 2016

Accepted: Aug 18, 2016

DOI: https://doi.org/10.1515/afpuc-2016-0006

Keywordsamitriptylin, citalopram, venlafaxine

© by M. Vicen

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
amitriptylin, citalopram, venlafaxine