<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge. Increased concentrations of this key enzyme are likely to cause a shift of kynurenine pathway towards enhanced production of neurotoxic metabolites. </p></abstract>

The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge. Increased concentrations of this key enzyme are likely to cause a shift of kynurenine pathway towards enhanced production of neurotoxic metabolites.

Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity

Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava

Comenius University Bratislava, Jessenius Faculty of Medicine in Martin, Department of Pharmacology, BioMed, Martin,

Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava,

Comenius University in Bratislava, Faculty of Pharmacy, Department of Galenic Pharmacy, Bratislava,

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of...

Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity

Published Online: Nov 23, 2016

Page range: 16 - 19

Received: Jun 24, 2016

Accepted: Jul 20, 2016

DOI: https://doi.org/10.1515/afpuc-2016-0001

Keywords
Immune challenge, Kynurenine-3-monooxygenase, Gender

© by L. Slovák

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity

Published Online: Nov 23, 2016

Page range: 16 - 19

Received: Jun 24, 2016

Accepted: Jul 20, 2016

DOI: https://doi.org/10.1515/afpuc-2016-0001

KeywordsImmune challenge, Kynurenine-3-monooxygenase, Gender

© by L. Slovák

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Immune challenge, Kynurenine-3-monooxygenase, Gender