<abstract xmlns="http://www.w3.org/1999/xhtml"><p> In present work, we have studied kinetics of alkaline hydrolysis of 14 compounds, which are phenylcarbamic acid derivatives with integrated N-phenylpiperazine moiety in the structure. The compounds possessed moderate antiarrhythmic and antimycobacterial activity. Their hydrolysis was carried out in an aqueous medium ethanol sodium hydroxide solution. The course of the hydrolysis was observed spectrophotometrically in visible as well as in ultraviolet regions. The pseudo-first order rate constants were calculated at several temperatures. The values of the activation energy E<sub>A</sub> were determined by the Arrhenius equation. The rate of hydrolysis of the compounds under the study increase with the increase in temperature and it has been differentiated according to the substitution of N-phenylpiperazine as well as to the alkoxy substitution on phenyl ring.</p></abstract>

In present work, we have studied kinetics of alkaline hydrolysis of 14 compounds, which are phenylcarbamic acid derivatives with integrated N-phenylpiperazine moiety in the structure. The compounds possessed moderate antiarrhythmic and antimycobacterial activity. Their hydrolysis was carried out in an aqueous medium ethanol sodium hydroxide solution. The course of the hydrolysis was observed spectrophotometrically in visible as well as in ultraviolet regions. The pseudo-first order rate constants were calculated at several temperatures. The values of the activation energy EA were determined by the Arrhenius equation. The rate of hydrolysis of the compounds under the study increase with the increase in temperature and it has been differentiated according to the substitution of N-phenylpiperazine as well as to the alkoxy substitution on phenyl ring.

Phenylcarbamic acid derivatives with integrated n-phenylpiperazine moiety in the structure – kinetics of alkaline hydrolysis study / Deriváty kyseliny fenylkarbámovej s integrovanou n-fenylpiperazínovou zložkou v štruktúre – štúdium kinetiky alkalickej hydrolýzy

Comenius University in Bratislava, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Bratislava, Slovak Republic

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

In present work, we have studied kinetics of alkaline hydrolysis of 14 compounds, which are phenylcarbamic acid derivatives with integrated N-phenylpiperazine...

Phenylcarbamic acid derivatives with integrated n-phenylpiperazine moiety in the structure – kinetics of alkaline hydrolysis study / Deriváty kyseliny fenylkarbámovej s integrovanou n-fenylpiperazínovou zložkou v štruktúre – štúdium kinetiky alkalickej hydrolýzy

Published Online: Dec 31, 2015

Page range: 38 - 42

Received: Sep 22, 2015

Accepted: Oct 28, 2015

DOI: https://doi.org/10.1515/afpuc-2015-0032

Keywords
Phenylcarbamic acid derivatives, Alkaline hydrolysis, Chemical kinetics, Antiarrhythmics, Stability

© by Stankovičová M.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Phenylcarbamic acid derivatives with integrated n-phenylpiperazine moiety in the structure – kinetics of alkaline hydrolysis study / Deriváty kyseliny fenylkarbámovej s integrovanou n-fenylpiperazínovou zložkou v štruktúre – štúdium kinetiky alkalickej hydrolýzy

Published Online: Dec 31, 2015

Page range: 38 - 42

Received: Sep 22, 2015

Accepted: Oct 28, 2015

DOI: https://doi.org/10.1515/afpuc-2015-0032

KeywordsPhenylcarbamic acid derivatives, Alkaline hydrolysis, Chemical kinetics, Antiarrhythmics, Stability

© by Stankovičová M.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Phenylcarbamic acid derivatives, Alkaline hydrolysis, Chemical kinetics, Antiarrhythmics, Stability