A study on blocking store-operated Ca²⁺ entry in pulmonary arterial smooth muscle cells with xyloketals from marine fungi

1. S. E. Peel, B. Liu and I. P. Hall, Orai and store-operated calcium influx in human airway smooth muscle cells, Am. J. Respir. Cell Molec. Biol. 38 (2008) 744-749; https://doi.org/10.1165/rcmb.2007-0395OC10.1165/rcmb.2007-0395OCSearch in Google Scholar

2. H. Mogami, K. Nakano, A. V. Tepikin and O. H. Petersen, Ca2+ flow via tunnels in polarized cells: recharging of apical Ca2+ stores by focal Ca2+ entry through basal membrane patch, Cell 88 (1997) 49-55; https://doi.org/10.1016/S0092-8674(00)81857-710.1016/S0092-8674(00)81857-7Search in Google Scholar

3. I. F. Abdullaev, J. M. Bisaillon, M. Potier, J. C. Gonzalez, R. K. Motiani and M. Trebak, Stim1 and orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation, Circ. Res. 103 (2008) 1289-1299; https://doi.org/10.1161/01.RES.0000338496.95579.5610.1161/01.RES.0000338496.95579.56268234718845811Search in Google Scholar

4. C. V. Remillard and J. X. J. Yuan, TRP channels, CCE, and the pulmonary vascular smooth muscle, Microcirculation 13 (2006) 671-692; https://doi.org/10.1080/1073968060093031310.1080/1073968060093031317085427Search in Google Scholar

5. M. Potier, J. C. Gonzalez, R. K. Motiani, I. F. Abdullaev, J. M. Bisaillon, H. A. Singer and M. Trebak, Evidence for STIM1- and Orai1-dependent store operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration, FASEB J. 23 (2009) 2425-2437; https://doi.org/10.1096/fj.09-13112810.1096/fj.09-131128271778419364762Search in Google Scholar

6. F. R. Giachini, C. W. Chiao, F. S. Carneiro, V. V. Lima, Z. N. Carneiro, A. M. Dorrance, R. C. Tostes and R. C. Webb, Increased activation of stromal interaction molecule-1/Orai-1 in aorta from hypertensive rats: a novel insight into vascular dysfunction, Hypertension 53 (2009) 409-416; https://doi.org/10.1161/HYPERTENSIONAHA.108.12440410.1161/HYPERTENSIONAHA.108.124404275326019075091Search in Google Scholar

7. R. W. Guo, H. Wang, P. Gao, M. Q. Li, C. Y. Zeng, Y. Yu, J. F. Chen, M. B. Song, Y. K. Shi and L. Huang, An essential role for stromal interaction molecule 1 in neointima formation following arterial injury, Cardiovasc. Res. 81 (2009) 660-668; https://doi.org/10.1093/cvr/cvn33810.1093/cvr/cvn33819052075Search in Google Scholar

8. A. Braun, D. Varga-Szabo, C. Kleinschnitz, I. Pleines, M. Bender, M. Austinat, M. Bösl, G. Stoll and B. Nieswandt, Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation, Blood 113 (2009) 2056-2063; https://doi.org/10.1182/blood-2008-07-17161110.1182/blood-2008-07-17161118832659Search in Google Scholar

9. A. Berna-Erro, A. Braun, R. Kraft, C. Kleinschnitz, M. K. Schuhmann, D. Stegner, T. Wultsch, J. Eilers, S. G. Meuth, G. Stoll and B. Nieswandt, STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death, Sci. Signal. 2 (2009) ra67; https://doi.org/10.1126/scisignal.200052210.1126/scisignal.200052219843959Search in Google Scholar

10. H. Zbidi, J. J. López, N. B. Amor, A. Bartegi, G. M. Salido and J. A. Rosado, Enhanced expression of STIM1/Orai1 and TRPC3 in platelets from patients with type 2 diabetes mellitus, Blood Cells Mol. Dis. 43 (2009) 211-213; https://doi.org/10.1016/j.bcmd.2009.04.00510.1016/j.bcmd.2009.04.00519447651Search in Google Scholar

11. M. Zhu, L. Chen, P. Zhao, H. Zhou, C. Zhang, S. Yu, Y. Lin and X. Yang, Store-operated Ca2+ entry regulates glioma cell migration and invasion via modulation of Pyk2 phosphorylation, J. Exp. Clin. Cancer Res. 33 (2014) 98-98; https://doi.org/10.1186/s13046-014-0098-110.1186/s13046-014-0098-1425825125433371Search in Google Scholar

12. M. Umemura, E. Baljinnyam, S. Feske, M. S. De Lorenzo, L.-H. Xie, X. Feng, K. Oda, A. Makino, T. Fujita, U. Yokoyama, M. Iwatsubo, S. Chen, J. S. Goydos, Y. Ishikawa and K. Iwatsubo, Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration, PLoS One 9 (2014) e89292; https://doi.org/10.1371/journal.pone.008929210.1371/journal.pone.0089292393174224586666Search in Google Scholar

13. J. Zhang, J. Wei, M. Kanada, L. Yan, Z. Zhang, H. Watanabe and S. Terakawa, Inhibition of storeoperated Ca2+ entry suppresses EGF-induced migration and eliminates extravasation from vasculature in nasopharyngeal carcinoma cell, Cancer Lett. 336 (2013) 390-397; https://doi.org/10.1016/j.canlet.2013.03.02610.1016/j.canlet.2013.03.02623623984Search in Google Scholar

14. C. Holzmann, T. Kilch, S. Kappel, A. Armbrüster, V. Jung, M. Stöckle, I. Bogeski, E. C. Schwarzand C. Peinelt, ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer, Oncotarget. 4 (2013) 2096-2107; https://doi.org/10.18632/oncotarget.148310.18632/oncotarget.1483387577224240085Search in Google Scholar

15. J. Wang, Q. Jiang, L. Wan, K. Yang, Y. Zhang, Y. Chen, E. Wang, N. Lai, L. Zhao, H. Jiang, Y. Sun, N. Zhong, P. Ran and W. Lu, Sodium tanshinone IIa sulfonate inhibits canonical transient receptor potential expression in pulmonary arterial smooth muscle from pulmonary hypertensive rats, Proc. Natl. Acad. Sci. USA 48 (2013) 125-134; https://doi.org/10.1165/rcmb.2012-0071OC10.1165/rcmb.2012-0071OC354708123065131Search in Google Scholar

16. S. Feske, ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+ entry in the immune system and beyond, Immunol. Rev. 231 (2009) 189-209; https://doi.org/10.1111/j.1600-065X.2009.00818.x10.1111/j.1600-065X.2009.00818.x901197619754898Search in Google Scholar

17. K. Ohga, R. Takezawa, T. Yoshino, T. Yamada , Y. Shimizu and J. Ishikawa, The suppressive effects of YM-58483/BTP-2, a store-operated Ca2+ entry blocker, on inflammatory mediator release in vitro and airway responses in vivo, Pulm. Pharmacol. Ther. 21 (2008) 360-369; https://doi.org/10.1016/j.pupt.2007.09.00310.1016/j.pupt.2007.09.00317977764Search in Google Scholar

18. P. B. Stathopulos, R. Schindl, M. Fahrner, L. Zheng, G. M. Gasmi-Seabrook, S. Gasmi, M. Muik, C. Romanin and M. Ikura, STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry, Nat. Commun. 12 (2013) 1-12; https://doi.org/10.1038/ncomms396310.1038/ncomms3963392787724351972Search in Google Scholar

19. Y. Lin, X. Wu, S. Feng, G. Jiang, J. Luo, S. Zhou, L. L. P. Vrijmoed, E. B. G. Jones, K. Krohn, K. Steingröver and F. Zsila, Five unique compounds: Xyloketals from mangrove fungus Xylaria sp. from the South China sea coast, J. Org. Chem. 66 (2001) 6252-6256; https://doi.org/10.1021/jo015522r10.1021/jo015522r11559170Search in Google Scholar

20. X. Y. Wu, X. H. Liu, Y. C. Lin, J. H. Luo, Z. G. She, H. J. Li, W. L. Chan, S. Antus, T. Kurtan, B. Elsässer and K. Krohn, Xyloketal F: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the South China sea coast, Eur. J. Org. Chem. 2005 (2005) 4061-4064; https://doi.org/10.1002/ejoc.20050032610.1002/ejoc.200500326Search in Google Scholar

21. Z. Xu, B. Lu, Q. Xiang, Y. Li, S. Li, Y. Lin and J. Pang, Radical-scavenging activities of marine-derived xyloketals and related chromanes, Acta Pharm. Sinca B 3 ( 2013) 3 22-327; https://doi.org/10.1016/j.apsb.2013.06.00810.1016/j.apsb.2013.06.008Search in Google Scholar

22. W. L. Chen, Y. Qian, W. F. Meng, J. Y. Pang, Y. C. Lin and Y. Y. Guan, A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro, Biochem. Pharmacol. 78 (2009) 941-950; https://doi.org/10.1016/j.bcp.2009.05.02910.1016/j.bcp.2009.05.02919481065Search in Google Scholar

23. Z. Xu, Y. Li, Q. Xiang, Z. Pei, X. Liu, B. Lu, L. Chen, G. Wang, J. Pang and Y. Lin, Design and synthesis of novel xyloketal derivatives and their vasorelaxing activities in rat thoracic aorta and angiogenic activities in zebrafish angiogenesis screen, J. Med. Chem. 53 (2010) 4642-4653; https://doi.org/10.1021/jm100150210.1021/jm100150220481602Search in Google Scholar

24. M. Romero, I. Sanchez and M. D. Pujol, New advances in the field of calcium channel antagonists: cardiovascular effects and structure-activity relationships, Curr. Med. Chem. 1 ( 2003) 113-141; https://doi.org/10.2174/156801603347748710.2174/156801603347748715320693Search in Google Scholar

25. G. B. Waypa, S. W. Osborne, J. D. Marks, S. K. Berkelhamer, J. Kondapalli and P. T. Schumacker, Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension, Amer. J. Respir. Cell Molec. Biol. 49 (2013) 885-891; https://doi.org/10.1165/rcmb.2013-0191OC10.1165/rcmb.2013-0191OC393112124047466Search in Google Scholar

26. B. Manoury, C. Lamalle, R. Oliveira, J. Reid and A. M. Gurney, Contractile and electrophysiological properties of pulmonary artery smooth muscle are not altered in TASK-1 knockout mice, J. Physiol. 589 (2011) 3231-3246; https://doi.org/10.1113/jphysiol.2011.20674810.1113/jphysiol.2011.206748314593621486782Search in Google Scholar

27. A. Ogawa, A. L. Firth, W. Yao, M. M. Madani, K. M. Kerr, W. R. Auger, S. W. Jamieson, P. A. Thistlethwaite and J. X. J. Yuan, Inhibition of mTOR attenuates store-operated Ca2+ entry i n cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension, Amer. J. Physiol. Lung Cell. Mol. Physiol. 297 (2009) L666-676; https://doi.org/10.1152/ajplung.90548.200810.1152/ajplung.90548.2008277079219633069Search in Google Scholar

28. K. Yang, W. Lu, Q. Jiang, X. Yun, M. Zhao, H. Jiang and J. Wang, Peroxisome proliferator-activated receptor γ-mediated inhibition on hypoxia-triggered store-operated calcium entry. A caveolin-1- dependent mechanism, Am. J. Respir. Cell Molec. Biol. 53 (2015) 882-892; https://doi.org/10.1165/rcmb.2015-0002OC10.1165/rcmb.2015-0002OC474294126020612Search in Google Scholar

29. K. V. Sandhya, G. S. Devi and S. T. Mathew, Liposomal formulations of serratiopeptidase: In vitro studies using PAMPA and Caco-2 models, Mol. Pharm. 5 (2008) 92-97; https://doi.org/10.1021/mp700090r10.1021/mp700090r18159928Search in Google Scholar

30. W. Zhang, Y. Liu, H. Yang, Z. Li, Y. Huang, Z. Xu, Y. Lin, Q. Xiang and J. Pang, A validated highperformance liquid chromatographic method with diode-array detection for the estimation of xyloketal B in rat plasma, J. Chromatogr. B Analyt. Technol. Bio. Life Sci. 855-856 (2012) 24-29; https://doi.org/10.1016/j.jchroma.2011.12.005Search in Google Scholar

31. M. Bédard, C. D. McClure, N. L. Schiller, C. Francoeur, A. Cantin and M. Denis, Release of interleukin- 8, interleukin-6, and colony-stimulating factors by upper airway epithelial cells: implications for cystic fibrosis, Am. J. Respir. Cell Mol. Biol. 9 (1993) 455-462; https://doi.org/10.1165/ajrcmb/9.4.45510.1165/ajrcmb/9.4.4557691110Search in Google Scholar

32. H. Balghi, R. Robert, B. Rappaz, X. Zhang, A. Wohlhuter-Haddad, A. Evagelidis, Y. Luo, J. Goepp, P. Ferraro, P. Roméo, M. Trebak, P. W. Wiseman, D. Y. Thomas and J. W. Hanrahan, Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways, FASEB J. 25 (2011) 4274-4291; https://doi.org/10.1096/fj.11-18768210.1096/fj.11-187682323662321873556Search in Google Scholar

33. G. W. Hunninghake and R. G. Crystal, Cigarette smoking and lung destruction: Accumulation of neutrophils in the lungs of cigarette smokers, Am. Rev. Respir. Dis. 128 (1983) 833-838; https://doi.org/10.1164/arrd.1983.128.5.833Search in Google Scholar

34. X. Yang, H. Jin, X. Cai, S. Li and Y. Shen, Structural and mechanistic insights into the activation of stromal interaction molecule 1 (STIM1), Proc. Natl. Acad. Sci. USA 109 (2012) 5657-5662; https://doi.org/10.1073/pnas.111894710910.1073/pnas.1118947109332644922451904Search in Google Scholar