<abstract xmlns="http://www.w3.org/1999/xhtml"><p> In this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to b cells bound to insulin. This approach was employed to create a welldefined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MIPs exhibited a high adsorption capacity for the target insulin, which showed a significantly higher release of insulin in solution at pH 7.4 than at pH 1.2. In vivo studies on diabetic Wistar rats showed that the fast onset within 2 h is similar to subcutaneous injection with a maximum at 4 h, giving an engaged function responsible for the duration of glucose reduction for up to 24 h. These MIPs, prepared as nanosized material, may open a new horizon for oral insulin delivery.</p></abstract>

In this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to b cells bound to insulin. This approach was employed to create a welldefined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MIPs exhibited a high adsorption capacity for the target insulin, which showed a significantly higher release of insulin in solution at pH 7.4 than at pH 1.2. In vivo studies on diabetic Wistar rats showed that the fast onset within 2 h is similar to subcutaneous injection with a maximum at 4 h, giving an engaged function responsible for the duration of glucose reduction for up to 24 h. These MIPs, prepared as nanosized material, may open a new horizon for oral insulin delivery.

Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

In this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites...

Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system

Article Category: Original research paper

Published Online: Jun 01, 2017

Page range: 149 - 168

Accepted: Mar 02, 2017

DOI: https://doi.org/10.1515/acph-2017-0020

Keywords
molecularly imprinted polymers, insulin, nanoparticles, islet cells, oral drug delivery

© by Roongnapa Suedee

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Supplementary Material Details

Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system

Article Category: Original research paper

Published Online: Jun 01, 2017

Page range: 149 - 168

Accepted: Mar 02, 2017

DOI: https://doi.org/10.1515/acph-2017-0020

Keywordsmolecularly imprinted polymers, insulin, nanoparticles, islet cells, oral drug delivery

© by Roongnapa Suedee

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Supplementary Material Details

Keywords
molecularly imprinted polymers, insulin, nanoparticles, islet cells, oral drug delivery