<abstract xmlns="http://www.w3.org/1999/xhtml"> Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeDeM profile. The mannitol based superdisintegrant Ludiflash® was characterized by the SeDeM-ODT expert system, which also allowed calculation of the optimal excipient concentration in order to obtain suitable tablet hardness and disintegration time. After adding a sweetener and a standard combination of lubricants, the optimized formulation was directly compressed into tablets and evaluated in terms of tablet hardness, friability, disintegration time and dissolution profile. The SeDeM method was applied to determine the amount of corrective excipient (Ludiflash®) required for the compression of Ibuprofen DC 85TM in order to achieve suitable ODTs. Adequate tablet hardness, disintegration time, friability and dissolution profiles were found during tablet evaluation.</abstract>

Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeDeM profile. The mannitol based superdisintegrant Ludiflash® was characterized by the SeDeM-ODT expert system, which also allowed calculation of the optimal excipient concentration in order to obtain suitable tablet hardness and disintegration time. After adding a sweetener and a standard combination of lubricants, the optimized formulation was directly compressed into tablets and evaluated in terms of tablet hardness, friability, disintegration time and dissolution profile. The SeDeM method was applied to determine the amount of corrective excipient (Ludiflash®) required for the compression of Ibuprofen DC 85TM in order to achieve suitable ODTs. Adequate tablet hardness, disintegration time, friability and dissolution profiles were found during tablet evaluation.

Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation,...

Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets

Article Category: Short communication

Published Online: Jun 01, 2017

Page range: 237 - 246

Accepted: Feb 04, 2017

DOI: https://doi.org/10.1515/acph-2017-0017

Keywords
Ibuprofen DC 85TM, Ludiflash®, orodispersible, SeDeM

© by Emőke-Margit Rédai

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets

Article Category: Short communication

Published Online: Jun 01, 2017

Page range: 237 - 246

Accepted: Feb 04, 2017

DOI: https://doi.org/10.1515/acph-2017-0017

KeywordsIbuprofen DC 85TM, Ludiflash®, orodispersible, SeDeM

© by Emőke-Margit Rédai

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Ibuprofen DC 85TM, Ludiflash®, orodispersible, SeDeM