<abstract xmlns="http://www.w3.org/1999/xhtml">The fabrication and development of two polyvinyl chloride (PVC) membrane sensors for assaying phenobarbitone sodium are described. Sensors 1 and 2 were fabricated utilizing β- or γ-cyclodextrin as ionophore in the presence of tridodecylmethylammonium chloride as a membrane additive, and PVC and dioctyl phthalate as plasticizer. The analytical parameters of both sensors were evaluated according to the IUPAC guidelines. The proposed sensors showed rapid, stable anionic response (-59.1 and -62.0 mV per decade) over a relatively wide phenobarbitone concentration range (5.0 × 10-6-1 × 10-2 and 8 × 10-6-1 × 10-2 mol L-1) in the pH range of 9-11. The limit of detection was 3.5 × 10-6 and 7.0 × 10-6 mol L-1 for sensors 1 and 2, respectively. The fabricated sensors showed high selectivity for phenobarbitone over the investigated foreign species. An average recovery of 2.54 μg mL-1 phenobarbitone sodium was 97.4 and 101.1 %, while the mean relative standard deviation was 3.0 and 2.1 %, for sensors 1 and 2, respectively. The results acquired for determination of phenobarbitone in its dosage forms utilizing the proposed sensors are in good agreement with those obtained by the British Pharmacopoeial method.</abstract>

The fabrication and development of two polyvinyl chloride (PVC) membrane sensors for assaying phenobarbitone sodium are described. Sensors 1 and 2 were fabricated utilizing β- or γ-cyclodextrin as ionophore in the presence of tridodecylmethylammonium chloride as a membrane additive, and PVC and dioctyl phthalate as plasticizer. The analytical parameters of both sensors were evaluated according to the IUPAC guidelines. The proposed sensors showed rapid, stable anionic response (-59.1 and -62.0 mV per decade) over a relatively wide phenobarbitone concentration range (5.0 × 10-6-1 × 10-2 and 8 × 10-6-1 × 10-2 mol L-1) in the pH range of 9-11. The limit of detection was 3.5 × 10-6 and 7.0 × 10-6 mol L-1 for sensors 1 and 2, respectively. The fabricated sensors showed high selectivity for phenobarbitone over the investigated foreign species. An average recovery of 2.54 μg mL-1 phenobarbitone sodium was 97.4 and 101.1 %, while the mean relative standard deviation was 3.0 and 2.1 %, for sensors 1 and 2, respectively. The results acquired for determination of phenobarbitone in its dosage forms utilizing the proposed sensors are in good agreement with those obtained by the British Pharmacopoeial method.

Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulations

Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box, 2457, Riyadh 11451,

Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box, 2457, Riyadh 11451, Saudi Arabia

Micro-Analytical Laboratory, Applied Organic Chemistry Department, National Research Center, Doki, Cairo,

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The fabrication and development of two polyvinyl chloride (PVC) membrane sensors for assaying phenobarbitone sodium are described. Sensors 1 and 2 were...

Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulations

Published Online: Oct 15, 2016

Page range: 503 - 514

Accepted: Jul 01, 2016

DOI: https://doi.org/10.1515/acph-2016-0042

Keywords
phenobarbitone sodium, membrane selective electrode, β-cyclodextrin, γ-cyclodextrin, PVC, potentiometry

© by Gamal A.E. Mostafa

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulations

Published Online: Oct 15, 2016

Page range: 503 - 514

Accepted: Jul 01, 2016

DOI: https://doi.org/10.1515/acph-2016-0042

Keywordsphenobarbitone sodium, membrane selective electrode, β-cyclodextrin, γ-cyclodextrin, PVC, potentiometry

© by Gamal A.E. Mostafa

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
phenobarbitone sodium, membrane selective electrode, β-cyclodextrin, γ-cyclodextrin, PVC, potentiometry