Effect of quercetin on the transport of ritonavir to the central nervous system in vitro and in vivo

1. S. A. Thomas, Anti-HIV drug distribution to the central nervous system, Curr. Pharm. Des.10 (2004) 1313–1324; DOI: 10.2174/1381612043384835.10.2174/138161204338483515134483Search in Google Scholar

2. J. A. Zastre, G. N. Chan, P. T. Ronaldson, M. Ramaswamy, P. O. Couraud, I. A. Romero, B. Weksler, M. Bendayan and R. Bendayan, Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line, J. Neurosci. Res.87 (2009) 1023–1036; DOI: 10.1002/jnr.21898.10.1002/jnr.2189818855943Search in Google Scholar

3. M. Ahn, S. Ghaemmaghami, Y. Huang, P. W. Phuan, B. C. May, K. Giles, S. J. DeArmond and S. B. Prusiner, Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter, PLoS One 7 (2012) e39112; DOI: 10.1371/journal.pone.0039112.10.1371/journal.pone.0039112338806822768295Search in Google Scholar

4. D. Pal, D. Kwatra, M. Minocha, D. K. Paturi, B. Budda and A. K. Mitra, Efflux transporters- and cytochrome P-450-mediated interactions between drugs of abuse and antiretrovirals, Life Sci.88 (2011) 959–971; DOI: 10.1016/j.lfs.2010.09.012.10.1016/j.lfs.2010.09.012310047520932495Search in Google Scholar

5. A. Antinori, G. Arendt, J. T. Becker, B. J. Brew, D. A. Byrd, M. Cherner, D. B. Clifford, P. Cinque, L. G. Epstein, K. Goodkin, M. Gisslen, I. Grant, R. K. Heaton, J. Joseph, K. Marder, C. M. Marra, J. C. McArthur, M. Nunn, R. W. Price, L. Pulliam, K. R. Robertson, N. Sacktor, V. Valcour and V. E. Wojna, Updated research nosology for HIV-associated neurocognitive disorders, Neurology69 (2007) 1789–1799; DOI: 10.1212/01.WNL.0000287431.88658.8b.10.1212/01.WNL.0000287431.88658.8b447236617914061Search in Google Scholar

6. L. Varatharajan and S. A. Thomas, The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research, Antiviral Res.82 (2009) A99–A109; DOI: 10.1016/j.antiviral.2008.12.013.10.1016/j.antiviral.2008.12.013267898619176219Search in Google Scholar

7. J. W. Polli, J. L. Jarrett, S. D. Studenberg, J. E. Humphreys, S. W. Dennis, K. R. Brouwer and J. L. Woolley, Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor, Pharm. Res.16 (1999) 1206–1212; DOI: 10.1023/A:1018941328702.10.1023/A:1018941328702Search in Google Scholar

8. E. F. Choo, B. Leake, C. Wandel, H. Imamura, A. J. Wood, G. R. Wilkinson and R. B. Kim, Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes, Drug Metab. Dispos.28 (2000) 655–60.Search in Google Scholar

9. S. Park and P. J. Sinko, P-glycoprotein and mutlidrug resistance-associated proteins limit the brain uptake of saquinavir in mice, J. Pharmacol. Exp. Ther.312 (2005) 1249–1256; DOI:10.1124/jpet.104.076216.10.1124/jpet.104.07621615528451Search in Google Scholar

10. C. J. Bachmeier, T. J. Spitzenberger, W. F. Elmquist and D. W. Miller, Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood–brain barrier, Pharm. Res.22 (2005) 1259–1268; DOI: 10.1007/s11095-005-5271-y.10.1007/s11095-005-5271-y16078135Search in Google Scholar

11. M. Hamidi, Role of P-glycoprotein in tissue uptake of indinavir in rat, Life Sci.79 (2006) 991–998; DOI: 10.1016/j.lfs.2006.05.010.10.1016/j.lfs.2006.05.01016793066Search in Google Scholar

12. U. Roy, C. Bulot, K. Höner zu Bentrup and D. Mondal, Specific increase in MDR1 mediated drug-efflux in human brain endothelial cells following co-exposure to HIV-1 and saquinavir, PLoS One8 (2013) e75374; DOI: 10.1371/journal.pone.0075374.10.1371/journal.pone.0075374378972624098380Search in Google Scholar

13. Z. Binkhathlan and A. Lavasanifar, P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: current status and future perspectives, Curr. Cancer Drug Targets13 (2013) 326–346; DOI: 10.2174/15680096113139990076.10.2174/1568009611313999007623369096Search in Google Scholar

14. A. Palmeira, E. Sousa, M. H. Vasconcelos and M. M. Pinto, Three decades of P-gp inhibitors: skimming through several generations and scaffolds, Curr. Med. Chem.19 (2012) 1946–2025; DOI: 10.2174/092986712800167392.10.2174/09298671280016739222257057Search in Google Scholar

15. H. A. Namanja, D. Emmert, D. A. Davis, C. Campos, D. S. Miller, C. A. Hrycyna and J. Chmielewski, Toward eradicating HIV reservoirs in the brain: inhibiting P-glycoprotein at the blood-brain barrier with prodrug abacavir dimers, J. Am. Chem. Soc.134 (2012) 2976–2980; DOI: 10.1021/ja206867t.10.1021/ja206867t326210421866921Search in Google Scholar

16. M. T. Sheu, Y. B. Liou, Y. H. Kao, Y. K. Lin and H. O. Ho, A quantitative structure-activity relationship for the modulation effects of flavonoids on p-glycoprotein-mediated transport, Chem. Pharm. Bull. (Tokyo) 58 (2010) 1187–1194; DOI: 10.1248/cpb.58.1187.10.1248/cpb.58.118720823598Search in Google Scholar

17. P. Limtrakul, O. Khantamat and K. Pintha, Inhibition of P-glycoprotein function and expression by kaempferol and quercetin, J. Chemother.17 (2005) 86–95; DOI: 10.1179/joc.2005.17.1.86.10.1179/joc.2005.17.1.8615828450Search in Google Scholar

18. D. Pal and A. K. Mitra, MDR- and CYP3A4-mediated drug-herbal interactions, Life Sci.78 (2006) 2131–2145; DOI: 10.1016/j.lfs.2005.12.010.10.1016/j.lfs.2005.12.01016442130Search in Google Scholar

19. J. Patel, B. Buddha, S. Dey, D. Pal and A. K. Mitra, In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: changes in P-gp and CYP3A4 activity, Am. J. Ther.11 (2004) 262–277.Search in Google Scholar

20. S. Zhou, X. Feng, P. Kestell, J. W. Paxton, B. C. Baguley and E. Chan, Transport of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide by human intestinal Caco-2 cells, Eur. J. Pharm. Sci.24 (2005) 513–524; DOI: 10.1016/j.ejps.2005.01.006.10.1016/j.ejps.2005.01.00615784341Search in Google Scholar

21. X.Y. Yu, S. G. Lin, Z. W. Zhou, X. Chen, J. Liang, X. Q. Yu, B. Chowbay, J. Y. Wen, W. Duan, E. Chan, X.T. Li, J. Cao, C. G. Li, C. C. Xue and S. F. Zhou, Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra, Pharm. Res.24 (2007) 1668–1690; DOI: 10.1007/s11095-007-9297-1.10.1007/s11095-007-9297-117551811Search in Google Scholar

22. Y. J. Moon and M. E. Morris, Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats, Mol. Pharm.4 (2007) 865–872; DOI: 10.1021/mp7000928.10.1021/mp700092817970592Search in Google Scholar

23. J. G. Sarver, W. A. Klis, J. P. Byers and P. W. Erhardt, Microplate screening of the differential effects of test agents on Hoechst 33342, rhodamine 123, and rhodamine 6G accumulation in breast cancer cells that overexpress P-glycoprotein, J. Biomol. Screen7 (2002) 29–34; DOI: 10.1177/108705710200700105.10.1177/10870571020070010511897053Search in Google Scholar

24. K. Berginc, I. Milisav and A. Kristl, Garlic flavonoids and organosulfur compounds: Impact on the hepatic pharmacokinetics of saquinavir and darunavir, Drug Metab. Pharmacokin.25 (2010) 521–530; DOI: JST.JSTAGE/dmpk/DMPK-10-RG-053 [pii].10.2133/dmpk.DMPK-10-RG-05320930421Search in Google Scholar

25. A. Di Pietro, G. Conseil, J. M. Pérez-Victoria, G. Dayan, H. Baubichon-Cortay, D. Trompier, E. Steinfels, J. M. Jault, H. de Wet, M. Maitrejean, G. Comte, A. Boumendjel, A. M. Mariotte, C. Dumontet, D. B. McIntosh, A. Goffeau, S. Castanys, F. Gamarro and D. Barron, Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters, Cell. Mol. Life Sci.59 (2002) 307–322; DOI: 10.1007/s00018-002-8424-8.10.1007/s00018-002-8424-811915946Search in Google Scholar

26. J. B. Vaidyanathan and T. Walle, Cellular uptake and efflux of the tea flavonoid (–)epicatechin-3-gallate in the human intestinal cell line Caco-2, J. Pharmacol. Exp. Ther.307 (2003) 745–752; DOI: 10.1124/jpet.103.054296.10.1124/jpet.103.05429612970388Search in Google Scholar

27. Y. Li, J. L. Revalde, G. Reid and J. W. Paxton, Interactions of dietary phytochemicals with ABC transporters: possible implications for drug disposition and multidrug resistance in cancer, Drug Metab. Rev.42 (2010) 590–611; DOI: 10.3109/03602531003758690.10.3109/0360253100375869020433315Search in Google Scholar