<abstract xmlns="http://www.w3.org/1999/xhtml"><p> In this study, a new drug product containing activated charcoal was designed and developed. The excipient levels in the pharmaceutical formulation were optimized using a mixture design approach. The adsorption power of the activated charcoal suspension was selected as the critical quality attribute influencing the efficacy of medical treatment. Significant prognostic models (p &lt; 0.05) were obtained to describe in detail the interrelations between excipient levels and the adsorption power of the formulation. Liquid flavour had a critical impact on the adsorption power of the suspension. Formulations containing the largest amount of liquid flavour showed the lowest adsorption power. Sorbitol was not adsorbed onto activated charcoal so strongly as liquid flavour. A slight increase in the content of carboxymethylcellulose sodium led to a marked decrease in adsorption power. The obtained mathematical models and response surface allowed selection of the optimal composition of excipients in a final drug product</p></abstract>

In this study, a new drug product containing activated charcoal was designed and developed. The excipient levels in the pharmaceutical formulation were optimized using a mixture design approach. The adsorption power of the activated charcoal suspension was selected as the critical quality attribute influencing the efficacy of medical treatment. Significant prognostic models (p < 0.05) were obtained to describe in detail the interrelations between excipient levels and the adsorption power of the formulation. Liquid flavour had a critical impact on the adsorption power of the suspension. Formulations containing the largest amount of liquid flavour showed the lowest adsorption power. Sorbitol was not adsorbed onto activated charcoal so strongly as liquid flavour. A slight increase in the content of carboxymethylcellulose sodium led to a marked decrease in adsorption power. The obtained mathematical models and response surface allowed selection of the optimal composition of excipients in a final drug product

Development and optimization of the activated charcoal suspension composition based on a mixture design approach

Department of Inorganic and Analytical Chemistry Faculty of Pharmacy Collegium Medicum Nicolaus Copernicus University in Toruń, 85-089 Bydgoszcz, Poland

Department of Pharmaceutical Technology Faculty of Pharmacy Collegium Medicum Nicolaus Copernicus University in Toruń, 85-089 Bydgoszcz, Poland

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

In this study, a new drug product containing activated charcoal was designed and developed. The excipient levels in the pharmaceutical formulation were...

Development and optimization of the activated charcoal suspension composition based on a mixture design approach

Published Online: Mar 11, 2015

Page range: 83 - 90

Received: Oct 10, 2014

DOI: https://doi.org/10.1515/acph-2015-0005

Keywords
activated charcoal, adsorption power, phenazone, experimental design, Quality by Design concept

© by Joanna Ronowicz

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Development and optimization of the activated charcoal suspension composition based on a mixture design approach

Published Online: Mar 11, 2015

Page range: 83 - 90

Received: Oct 10, 2014

DOI: https://doi.org/10.1515/acph-2015-0005

Keywordsactivated charcoal, adsorption power, phenazone, experimental design, Quality by Design concept

© by Joanna Ronowicz

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
activated charcoal, adsorption power, phenazone, experimental design, Quality by Design concept