<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Burning, itching and dyspareunia are typical symptoms of many genital diseases. These subjective complaints can be misdiagnosed because of different clinical presentations. We present a case report of a postmenopausal woman treated for genital warts over a period of three years followed by the development of leukoplastic lesions in the whitish area clinical classified as Lichen sclerosus (LS). Histology of this lesion revealed carcinoma in situ. After radical surgical removal, vulvar Paget’s disease was histologically verified. LS and extramammary Paget's disease (EMPD) belong to a group of uncommon dermatoses which mainly affect the skin of the genitals in postmenopausal women. Ulceration, erosions and leukoplastic lesions can signalize the development of squamous cell carcinoma in association of lichen sclerosus, on the other hand, they can be the sign of EMPD after a long period of time using different topical agents. The importance of reaching the correct diagnosis is essential and can influence current patient investigations and invasive or non-invasive treatment.</p></abstract>

Burning, itching and dyspareunia are typical symptoms of many genital diseases. These subjective complaints can be misdiagnosed because of different clinical presentations. We present a case report of a postmenopausal woman treated for genital warts over a period of three years followed by the development of leukoplastic lesions in the whitish area clinical classified as Lichen sclerosus (LS). Histology of this lesion revealed carcinoma in situ. After radical surgical removal, vulvar Paget’s disease was histologically verified. LS and extramammary Paget's disease (EMPD) belong to a group of uncommon dermatoses which mainly affect the skin of the genitals in postmenopausal women. Ulceration, erosions and leukoplastic lesions can signalize the development of squamous cell carcinoma in association of lichen sclerosus, on the other hand, they can be the sign of EMPD after a long period of time using different topical agents. The importance of reaching the correct diagnosis is essential and can influence current patient investigations and invasive or non-invasive treatment.

Extramammary Paget’s Disease Versus Lichen Sclerosus

Comenius University Jessenius Faculty of Medicine and University Hospital, Department of Dermatovenerology, Martin, Slovak Republic

Comenius University, Jessenius Faculty of Medicine and University Hospital, Department of Pathology, Martin, Slovak Republic

Acta Medica Martiniana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Extramammary Paget\u2019s Disease Versus Lichen Sclerosus"}

Burning, itching and dyspareunia are typical symptoms of many genital diseases. These subjective complaints can be misdiagnosed because of different clinical...

Extramammary Paget’s Disease Versus Lichen Sclerosus

Published Online: Mar 01, 2017

Page range: 43 - 46

Received: Oct 10, 2016

Accepted: Nov 16, 2016

DOI: https://doi.org/10.1515/acm-2016-0016

Keywords
Lichen sclerosus, extramammary Paget's disease, leukoplastic lesion

© 2016 Pappova, T. et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Extramammary Paget’s Disease Versus Lichen Sclerosus

Published Online: Mar 01, 2017

Page range: 43 - 46

Received: Oct 10, 2016

Accepted: Nov 16, 2016

DOI: https://doi.org/10.1515/acm-2016-0016

KeywordsLichen sclerosus, extramammary Paget's disease, leukoplastic lesion

© 2016 Pappova, T. et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Lichen sclerosus, extramammary Paget's disease, leukoplastic lesion