<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Severe dengue infection is associated with life-threatening complications, including severe bleeding. The bleeding tendency is typically associated with the shock phase of infection, for which blood replacement may be needed. However, repetitive blood transfusion can lead to volume overload. Administration of recombinant activated factor VII (rFVIIa) might be used to counteract bleeding without inducing volume overload. We describe the case of a patient with severe dengue infection who presented with intractable bleeding; he was initially treated with massive blood transfusions, which resulted in volume overload. He was then treated with rFVIIa to reverse the bleeding. During the second week of his hospitalization, his hematocrit dropped precipitously, and autoimmune hemolytic anemia was diagnosed. Supportive treatment was provided until recovery. Autoimmune hemolytic anemia is a rare complication in adult patients with dengue. Supportive care was effective for this atypical complication.</p></abstract>

Severe dengue infection is associated with life-threatening complications, including severe bleeding. The bleeding tendency is typically associated with the shock phase of infection, for which blood replacement may be needed. However, repetitive blood transfusion can lead to volume overload. Administration of recombinant activated factor VII (rFVIIa) might be used to counteract bleeding without inducing volume overload. We describe the case of a patient with severe dengue infection who presented with intractable bleeding; he was initially treated with massive blood transfusions, which resulted in volume overload. He was then treated with rFVIIa to reverse the bleeding. During the second week of his hospitalization, his hematocrit dropped precipitously, and autoimmune hemolytic anemia was diagnosed. Supportive treatment was provided until recovery. Autoimmune hemolytic anemia is a rare complication in adult patients with dengue. Supportive care was effective for this atypical complication.

Atypical complication in an adult patient with dengue and autoimmune hemolytic anemia: a case report

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine

Hospital for Tropical Diseases, Faculty of Tropical Medicine

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Severe dengue infection is associated with life-threatening complications, including severe bleeding. The bleeding tendency is typically associated with the...

Atypical complication in an adult patient with dengue and autoimmune hemolytic anemia: a case report

Article Category: Clinical vignette

Published Online: Feb 21, 2021

Page range: 43 - 48

DOI: https://doi.org/10.1515/abm-2021-0006

Keywords
anemia, hemolytic, autoimmune, blood coagulation disorders, blood component transfusion, recombinant FVIIa, severe dengue

© 2021 Supat Chamnanchanunt et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Atypical complication in an adult patient with dengue and autoimmune hemolytic anemia: a case report

Article Category: Clinical vignette

Published Online: Feb 21, 2021

Page range: 43 - 48

DOI: https://doi.org/10.1515/abm-2021-0006

Keywordsanemia, hemolytic, autoimmune, blood coagulation disorders, blood component transfusion, recombinant FVIIa, severe dengue

© 2021 Supat Chamnanchanunt et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
anemia, hemolytic, autoimmune, blood coagulation disorders, blood component transfusion, recombinant FVIIa, severe dengue