<abstract xmlns="http://www.w3.org/1999/xhtml"><sec><h3>Background</h3><p>Gastrointestinal stromal tumor (GIST) was the most common mesenchymal tumor of the gastrointestinal tract predominately occurring in the stomach. Although GIST was a rare disease, it was considered to be a life-threatening malignancy.</p></sec><sec><h3>Objective</h3><p>To explore the current status of gastric GIST in Thai patients.</p></sec><sec><h3>Method</h3><p>The medical records of patients who were diagnosed with histologically proven gastric GIST from 2012 to 2016 in King Chulalongkorn Memorial Hospital were reviewed.</p></sec><sec><h3>Results</h3><p>Of 22 patients, there were 14 (63.6%) females and 8 (36.4%) males with the mean age of 62.6 ± 14.8 years. The average duration before the first presentation was 12 weeks. The initial symptoms were upper gastrointestinal bleeding (50.0%) followed by abdominal pain (31.8%). Tumor mostly located at the proximal part (fundus and cardia) in 20 (90.9%) patients. At the time of the diagnosis, three patients (13.6%) had distant metastasis. Of this group, 77.3% underwent surgical treatment.</p></sec><sec><h3>Discussion</h3><p>Although gastric GIST was an uncommon disease, early diagnosis and prompt treatment could save the lives of many patients.</p></sec></abstract>

BackgroundGastrointestinal stromal tumor (GIST) was the most common mesenchymal tumor of the gastrointestinal tract predominately occurring in the stomach. Although GIST was a rare disease, it was considered to be a life-threatening malignancy.ObjectiveTo explore the current status of gastric GIST in Thai patients.MethodThe medical records of patients who were diagnosed with histologically proven gastric GIST from 2012 to 2016 in King Chulalongkorn Memorial Hospital were reviewed.ResultsOf 22 patients, there were 14 (63.6%) females and 8 (36.4%) males with the mean age of 62.6 ± 14.8 years. The average duration before the first presentation was 12 weeks. The initial symptoms were upper gastrointestinal bleeding (50.0%) followed by abdominal pain (31.8%). Tumor mostly located at the proximal part (fundus and cardia) in 20 (90.9%) patients. At the time of the diagnosis, three patients (13.6%) had distant metastasis. Of this group, 77.3% underwent surgical treatment.DiscussionAlthough gastric GIST was an uncommon disease, early diagnosis and prompt treatment could save the lives of many patients.

Clinical features and immunohistochemistry profile of biopsy-proven gastric gastrointestinal stromal tumor (GIST): a description of 5 years case series and literature review of GIST

Department of Physiology, Faculty of Medicine

Department of Pathology, Faculty of Medicine

Department of Medicine, Faculty of Medicine

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

BackgroundGastrointestinal stromal tumor (GIST) was the most common mesenchymal tumor of the gastrointestinal tract predominately occurring in the stomach....

Case no	CD34	CD117	DOG1	S-100	SMA	MSA	Vimentin	Ki67
1	Positive	Positive		Positive	Positive			Positive
2	Positive	Positive	Positive	Negative			Positive
3	Positive	Positive	Positive	Negative	Negative
4	Negative	Negative	Negative	Negative	Positive	Positive	Positive
5	Positive	Positive		Negative	Negative		Positive	Negative
6	Positive	Positive		Negative	Negative
7		Positive						Negative
8		Positive	Positive	Negative	Negative
9	Positive	Positive	Positive	Negative	Negative			Positive
10		Positive	Positive					Positive
11			Positive
12	Positive	Negative	Negative	Negative	Negative	Negative	Positive
13	Positive	Positive	Positive	Negative	Negative			Negative
14		Positive	Positive				Positive	Negative
15	Positive	Positive	Positive
16		Positive	Positive					Positive
17	Positive	Positive	Positive	Negative	Negative	Negative		Positive
18	Positive	Positive	Positive	Negative	Negative
19		Positive
20	Positive	Positive	Positive	Negative	Negative	Negative		Positive
21	Positive	Positive	Positive	Negative	Negative	Negative	Positive	Positive
22	Positive	Positive		Negative				Positive

Case no	Sex	Age (years)	Tumor location	Size (cm)	Mitotic rate (per 50 HPF)	HP test	Treatment	Outcome
1	Male	86	Cardia	N/A	N/A	Pos	None	DOD
2	Male	68	Body	7.0	4	N/A	Surgery	NED
3	Female	67	Cardia	2.4	1	Pos	Surgery	LDP
4	Female	42	Cardia	4.5	1	N/A	Surgery	NED
5	Female	49	Cardia	1.5	1	N/A	Surgery	NED
6	Male	46	N/A	2.1	10	N/A	Surgery	NED
7	Female	72	Antrum	2.7	2	Neg	Surgery	NED
8	Female	54	Body	3.4	3	N/A	Surgery	NED
9	Female	59	Body	4.0	<5	N/A	Surgery	NED
10	Female	69	Cardia	5.0	2	N/A	Surgery	NED
11	Female	42	Fundus	2.2	1	N/A	Surgery	NED
12	Male	71	Fundus	4.7	<5	N/A	Surgery	NED
13	Female	59	Body	10.8	2	Neg	Surgery	NED
14	Female	60	Body	4.5	3	N/A	Surgery	NED
15	Female	83	Body	2.5	4	N/A	Surgery	NED
16	Male	42	Body	4.0	>10	N/A	Surgery	NED
17	Male	44	Body	5.0	2	N/A	Surgery	NED
18	Female	95	Body	5.5	4	Pos	Surgery	NED
19	Male	67	Fundus	N/A	N/A	Pos	CMT	LDP
20	Female	74	Body	N/A	N/A	N/A	CMT	DOD
21	Male	68	Body	7.5	108	N/A	Surgery + CMT	LDP
22	Female	61	Fundus	11.0	11	Neg	Surgery + CMT	LDP

Clinical features and immunohistochemistry profile of biopsy-proven gastric gastrointestinal stromal tumor (GIST): a description of 5 years case series and literature review of GIST

Article Category: Brief communication (original)

Published Online: Sep 10, 2020

Page range: 111 - 117

DOI: https://doi.org/10.1515/abm-2020-0017

Keywords
gastric, gastrointestinal stromal tumor, stomach

© 2020 Chuthamas Ongprakobkul et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Figure 2

Figure 3

Figure 4

Immunohistochemistry study of patients

Baseline characteristics, tumor locations, size, mitotic rate of tumors, HP test, treatment, and outcome

Clinical features and immunohistochemistry profile of biopsy-proven gastric gastrointestinal stromal tumor (GIST): a description of 5 years case series and literature review of GIST

Article Category: Brief communication (original)

Published Online: Sep 10, 2020

Page range: 111 - 117

DOI: https://doi.org/10.1515/abm-2020-0017

Keywordsgastric, gastrointestinal stromal tumor, stomach

© 2020 Chuthamas Ongprakobkul et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Figure 2

Figure 3

Figure 4

Immunohistochemistry study of patients

Baseline characteristics, tumor locations, size, mitotic rate of tumors, HP test, treatment, and outcome

Keywords
gastric, gastrointestinal stromal tumor, stomach