<abstract xmlns="http://www.w3.org/1999/xhtml"><sec><h3>Background</h3><p>Epidermal growth factor receptor (<italic>EGFR</italic>) sequence variants in patients from Myanmar have not yet been reported.</p></sec><sec><h3>Objectives</h3><p>To describe the molecular epidemiology of <italic>EGFR</italic> variants in patients from Myanmar with lung adenocarcinoma.</p></sec><sec><h3>Methods</h3><p>Histological diagnosis and categorization of biopsies collected from 66 patients (28–78 years) with lung cancer was conducted using a panel of antibodies including those to: TTF1, P40, synaptophysin, CK7, and napsin-A. Samples from patients with confirmed adenocarcinoma were tested for <italic>EGFR</italic> variants using a cobas EGFR Mutation Test kit and cobas z 480 System (Roche). We conducted a univariate analysis of categorical factors using a χ<sup>2</sup> or Fisher exact test.</p></sec><sec><h3>Results</h3><p>Histological types were adenocarcinoma (61%, 40/66), squamous cell carcinoma (24%, 16/66), neuroendocrine carcinoma (9%, 6/66), undifferentiated carcinoma (2%, 1/66), adenosquamous carcinoma (2%, 1/66), small cell anaplastic carcinoma (2%, 1/66), and pleomorphic sarcoma (2%, 1/66). <italic>EGFR</italic> variants were detected in 15 of 40 (38%) cases of adenocarcinoma. Among them, 6 patients (40%) had an exon 19 deletion, another 6 (40%) had exon 21 substitutions, 1 (7%) had exon 20 insertion S768I, and 2 (13%) had compound variations (1 of exon 21 L858R and exon 18 G719X, and 1 of exon 20 S768I and exon 18 G719X). Although limited by small sample size, no significant association was found between the variants and factors including family cancer history, age group, sex, ethnicity, or occupation. However, there was a strong significant association between never-smokers and <italic>EGFR</italic> variants (<italic>P</italic> = 0.008).</p></sec><sec><h3>Conclusion</h3><p>Knowledge of <italic>EGFR</italic> variants in patients from Myanmar is encouraging for their effective cancer treatment.</p></sec></abstract>

BackgroundEpidermal growth factor receptor (EGFR) sequence variants in patients from Myanmar have not yet been reported.ObjectivesTo describe the molecular epidemiology of EGFR variants in patients from Myanmar with lung adenocarcinoma.MethodsHistological diagnosis and categorization of biopsies collected from 66 patients (28–78 years) with lung cancer was conducted using a panel of antibodies including those to: TTF1, P40, synaptophysin, CK7, and napsin-A. Samples from patients with confirmed adenocarcinoma were tested for EGFR variants using a cobas EGFR Mutation Test kit and cobas z 480 System (Roche). We conducted a univariate analysis of categorical factors using a χ2 or Fisher exact test.ResultsHistological types were adenocarcinoma (61%, 40/66), squamous cell carcinoma (24%, 16/66), neuroendocrine carcinoma (9%, 6/66), undifferentiated carcinoma (2%, 1/66), adenosquamous carcinoma (2%, 1/66), small cell anaplastic carcinoma (2%, 1/66), and pleomorphic sarcoma (2%, 1/66). EGFR variants were detected in 15 of 40 (38%) cases of adenocarcinoma. Among them, 6 patients (40%) had an exon 19 deletion, another 6 (40%) had exon 21 substitutions, 1 (7%) had exon 20 insertion S768I, and 2 (13%) had compound variations (1 of exon 21 L858R and exon 18 G719X, and 1 of exon 20 S768I and exon 18 G719X). Although limited by small sample size, no significant association was found between the variants and factors including family cancer history, age group, sex, ethnicity, or occupation. However, there was a strong significant association between never-smokers and EGFR variants (P = 0.008).ConclusionKnowledge of EGFR variants in patients from Myanmar is encouraging for their effective cancer treatment.

Epidermal growth factor receptor variants in patients from Myanmar with lung adenocarcinoma

prof.khinesanyin@innovativediagnosticsmyanmar.com

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

BackgroundEpidermal growth factor receptor (EGFR) sequence variants in patients from Myanmar have not yet been reported.ObjectivesTo describe the molecular...

Characteristic	Total	EGFR variation		P

		Detected (%)	Not detected (%)
Family cancer history
Present	7	2 (29%)	5 (71%)	0.69
Absent	33	13 (39%)	20 (61%)
Age group
<40 years	1	1 (100%)	0 (0%)	0.35
40–59 years	11	5 (45%)	6 (55%)
≥60 years	28	9 (32%)	19 (68%)
Sex
Male	19	5 (26%)	14 (74%)	0.17
Female	21	10 (48%)	11 (52%)
Ethnicity
Bamar	38	15 (39%)	23 (61%)	0.52
Kayin	2	0 (0.0%)	2 (100%)
Occupation
Unemployed	18	9 (50%)	9 (50%)	0.60
Service and sale workers	7	1 (14%)	6 (86%)
Officers/managers	5	1 (20%)	4 (80%)
Professionals	3	1 (33%)	2 (67%)
Armed forces occupations	3	2 (67%)	1 (33%)
Technicians	1	0 (0%)	1 (100%)
Transporters	2	1 (50%)	1 (50%)
Agricultural, forestry, and fishery workers	1	0 (0%)	1 (100%)
Smoking habit
Regular smokers	4	0 (0%)	4 (100%)	0.008*
Ex-smokers	21	5 (24%)	16 (76%)
Never-smokers	15	10 (67%)	5 (33%)
Chemical/dust exposure
Exposure present	9	1 (11%)	8 (89%)	0.12
No exposure	31	14 (45%)	17 (55%)

Epidermal growth factor receptor variants in patients from Myanmar with lung adenocarcinoma

Article Category: Brief communication (original)

Published Online: Aug 04, 2020

Page range: 75 - 81

DOI: https://doi.org/10.1515/abm-2020-0011

Keywords
adenocarcinoma of lung, EGFR protein, human, ErbB receptors, Myanmar, carcinoma, non-small-cell lung

© 2020 Khine San Yin et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Figure 2

Association between EGFR variation and clinical features

Epidermal growth factor receptor variants in patients from Myanmar with lung adenocarcinoma

Article Category: Brief communication (original)

Published Online: Aug 04, 2020

Page range: 75 - 81

DOI: https://doi.org/10.1515/abm-2020-0011

Keywordsadenocarcinoma of lung, EGFR protein, human, ErbB receptors, Myanmar, carcinoma, non-small-cell lung

© 2020 Khine San Yin et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Figure 2

Association between EGFR variation and clinical features

Keywords
adenocarcinoma of lung, EGFR protein, human, ErbB receptors, Myanmar, carcinoma, non-small-cell lung