Open Access

(2E)-2-Benzylidene-4,7-dimethyl-2,3-dihydro-1H-inden-1-one (MLT-401), a novel arylidene indanone derivative, scavenges free radicals and exhibits antiproliferative activity of Jurkat cells


Cite

Hoake JB, Pastorino JG. Ethanol, oxidative stress and cytokine-induced liver cell injury. Alcohol. 2002; 27:63–8.HoakeJBPastorinoJGEthanol, oxidative stress and cytokine-induced liver cell injuryAlcohol20022763810.1016/S0741-8329(02)00215-XSearch in Google Scholar

Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K. Oxidative stress, prooxidants, and antioxidants: the interplay. BioMed Res Int. 2014; 761264. doi:10.1155/2014/761264RahalAKumarASinghVYadavBTiwariRChakrabortySDhamaKOxidative stress, prooxidants, and antioxidants: the interplayBioMed Res Int201476126410.1155/2014/761264392090924587990Open DOISearch in Google Scholar

Gillet JP, Gottesman MM. Mechanisms of multidrug resistance in cancer. Methods Mol Biol. 2010; 596:47–76.GilletJPGottesmanMMMechanisms of multidrug resistance in cancerMethods Mol Biol2010596477610.1007/978-1-60761-416-6_419949920Search in Google Scholar

Schmitz KJ, Otterbach F, Callies R, Levkau B, Hölscher M, Hoffmann O, et al. Prognostic relevance of activated Akt kinase in node-negative breast cancer: a clinicopathological study of 99 cases. Mod Pathol. 2004; 17:15–21.SchmitzKJOtterbachFCalliesRLevkauBHölscherMHoffmannOPrognostic relevance of activated Akt kinase in node-negative breast cancer: a clinicopathological study of 99 casesMod Pathol200417152110.1038/modpathol.380000214631376Search in Google Scholar

Fodouop SPC, Simo RT, Amvene JM, Talla E, Etet PFS, Takam P, et al. Bioactivity and therapeutic potential of plant extracts in cancer and infectious diseases. J Dis Med Plants. 2015; 1:8–18.FodouopSPCSimoRTAmveneJMTallaEEtetPFSTakamPBioactivity and therapeutic potential of plant extracts in cancer and infectious diseasesJ Dis Med Plants20151818Search in Google Scholar

Özdemir A, Turan-Zitouni G, Kaplancikli ZA, Tunali Y. Synthesis and biological activities of new hydrazide derivatives. J Enzyme Inhib Med Chem. 2008; 29:1–13.ÖzdemirATuran-ZitouniGKaplancikliZATunaliYSynthesis and biological activities of new hydrazide derivativesJ Enzyme Inhib Med Chem20082911310.1080/1475636080239971218825530Search in Google Scholar

Kaplancikli ZA, Turan-Zitouni G, Ozdemir A, Teulade J-C. Synthesis and antituberculosis activity of new hydrazide derivatives. Arch Pharm Chem Life Sci. 2008; 20:20–8.KaplancikliZATuran-ZitouniGOzdemirATeuladeJ-CSynthesis and antituberculosis activity of new hydrazide derivativesArch Pharm Chem Life Sci20082020810.1002/ardp.20080004818720343Search in Google Scholar

Geronikaki A, Eleftheriou P, Vicini P, Alam I, Dixit A, Saxena AK. 2-Thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action. J Med Chem. 2008; 51:5221–8.GeronikakiAEleftheriouPViciniPAlamIDixitASaxenaAK2-Thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory actionJ Med Chem2008515221810.1021/jm800430618702480Search in Google Scholar

Abdelrazek FM, Metz P, Kataeva O, Jäger A, El-Mahrouky SF. Synthesis and molluscicidal activity of new chromene and pyrano[2,3-c]pyrazole derivatives. Arch Pharm. 2007; 340:543–8.AbdelrazekFMMetzPKataevaOJägerAEl-MahroukySFSynthesis and molluscicidal activity of new chromene and pyrano[2,3-c]pyrazole derivativesArch Pharm2007340543810.1002/ardp.20070015717912679Search in Google Scholar

Ottanà R, Maccari R, Ciurleo R, Vigorita MG, Panico AM, Cardile V, et al. Synthesis and in vitro evaluation of 5-arylidene-3-hydro-xyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures. Bioorg Med Chem. 2007; 15:7618–25.OttanàRMaccariRCiurleoRVigoritaMGPanicoAMCardileVSynthesis and in vitro evaluation of 5-arylidene-3-hydro-xyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte culturesBioorg Med Chem20071576182510.1016/j.bmc.2007.09.00117889545Search in Google Scholar

da Costa Leite LF, Veras Mourão RH, de Lima Mdo C, Galdino SL, Hernandes MZ, de Assis Rocha Neves F, et al. Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities. Eur J Med Chem. 2007; 42:1263–71.da Costa LeiteLFVeras MourãoRHde Lima MdoCGaldinoSLHernandesMZde Assis Rocha NevesFSynthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activitiesEur J Med Chem20074212637110.1016/j.ejmech.2007.02.01517448573Search in Google Scholar

Bansal R, Guleria S. Synthesis of 16E-[3-methoxy-4-(2minoethoxy) benzylidene]androstene derivatives as potent cytotoxic agents. Steroids. 2008; 73:1391–9.BansalRGuleriaSSynthesis of 16E-[3-methoxy-4-(2minoethoxy) benzylidene]androstene derivatives as potent cytotoxic agentsSteroids2008731391910.1016/j.steroids.2008.07.00418694772Search in Google Scholar

Menezes JCJMDS. Arylidene indanone scaffold: medicinal chemistry and structure–activity relationship view. RSC Adv. 2017; 7:9357–72.MenezesJCJMDSArylidene indanone scaffold: medicinal chemistry and structure–activity relationship viewRSC Adv2017793577210.1039/C6RA28613ESearch in Google Scholar

Pati HN, Das U, De Clercq E, Balzarini J, Dimmock JR. Molecular modifications of 2-arylidene-1-indanones leading to increased cytotoxic potencies. J Enzyme Inhib Med Chem. 2007; 22:37–42.PatiHNDasUDe ClercqEBalzariniJDimmockJRMolecular modifications of 2-arylidene-1-indanones leading to increased cytotoxic potenciesJ Enzyme Inhib Med Chem200722374210.1080/1475636060095805717373545Search in Google Scholar

Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev. 2004 56:185–229.MinottiGMennaPSalvatorelliECairoGGianniLAnthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicityPharmacol Rev20045618522910.1124/pr.56.2.615169927Search in Google Scholar

Carrera MP, Ramírez-Expósito MJ, Martínez-Martos JM. Actual and potential agents and biomarkers in the treatment of cancer. Anti-cancer Agents Med Chem. 2009; 9:500–16.CarreraMPRamírez-ExpósitoMJMartínez-MartosJMActual and potential agents and biomarkers in the treatment of cancerAnti-cancer Agents Med Chem200995001610.2174/18715200978845182419519292Search in Google Scholar

Rajagopalan P, Alahmari KA, Elbessoumy AA, Balasubramaniam M, Suresh R, Shariff MEA, Chandramoorthy HC. Biological evaluation of 2-arylidene-4, 7-dimethyl indan-1-one (FXY-1): a novel Akt inhibitor with potent activity in lung cancer. Cancer Chemother Pharmacol. 2016; 77:393–404.RajagopalanPAlahmariKAElbessoumyAABalasubramaniamMSureshRShariffMEAChandramoorthyHCBiological evaluation of 2-arylidene-4, 7-dimethyl indan-1-one (FXY-1): a novel Akt inhibitor with potent activity in lung cancerCancer Chemother Pharmacol20167739340410.1007/s00280-015-2956-826781309Search in Google Scholar

Becker K, Schroecksnadel S, Gostner J, Zaknun C, Schennach H, Überall F, Fuchs D. Comparison of in vitro tests for antioxidant and immunomodulatory capacities of compounds. Phytomedicine. 2014; 21:164–71.BeckerKSchroecksnadelSGostnerJZaknunCSchennachHÜberallFFuchsDComparison of in vitro tests for antioxidant and immunomodulatory capacities of compoundsPhytomedicine2014211647110.1016/j.phymed.2013.08.00824041614Search in Google Scholar

Moon JK, Shibamoto T. Antioxidant assays for plant and food components. J Agric Food Chem. 2009; 57:1655–66.MoonJKShibamotoTAntioxidant assays for plant and food componentsJ Agric Food Chem20095716556610.1021/jf803537k19182948Search in Google Scholar

Lee HJ, Kim TH, Kim JN. One-pot synthesis of (E)-2-arylideneindan-1-ones from the Baylis-Hillman adducts via the successive inter- and intramolecular Friedel-Crafts reactions. Bull Korean Chem Soc. 2001; 22:1059–68.LeeHJKimTHKimJNOne-pot synthesis of (E)-2-arylideneindan-1-ones from the Baylis-Hillman adducts via the successive inter- and intramolecular Friedel-Crafts reactionsBull Korean Chem Soc20012210596810.1002/chin.200216119Search in Google Scholar

Prasanna R, Harish CC. Anticancer effect of a novel 2-arylidene-4,7-dimethyl indan-1-one against human breast adenocarcinoma cell line by G2/M cell cycle arrest. Oncology Res. 2010; 18:461–8.PrasannaRHarishCCAnticancer effect of a novel 2-arylidene-4,7-dimethyl indan-1-one against human breast adenocarcinoma cell line by G2/M cell cycle arrestOncology Res201018461810.3727/096504010X1270491612474720681405Search in Google Scholar

Dzoyem JP, Eloff JN. Anti-inflammatory, anticholinesterase and antioxidant activity of leaf extracts of twelve plants used traditionally to alleviate pain and inflammation in South Africa. J Ethnopharmacol. 2015; 160:194–201.DzoyemJPEloffJNAnti-inflammatory, anticholinesterase and antioxidant activity of leaf extracts of twelve plants used traditionally to alleviate pain and inflammation in South AfricaJ Ethnopharmacol201516019420110.1016/j.jep.2014.11.034Search in Google Scholar

Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65:55–63.MosmannTRapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assaysJ Immunol Methods198365556310.1016/0022-1759(83)90303-4Search in Google Scholar

Solomson LP, Liepkalns VA, Spector A. Changes in (Na+ + K+)-ATPase activity of Ehrlich ascites tumor cells produced by alteration of fatty acid composition. Biochem. 1976; 15:892–7.SolomsonLPLiepkalnsVASpectorAChanges in (Na+ + K+)-ATPase activity of Ehrlich ascites tumor cells produced by alteration of fatty acid compositionBiochem197615892710.1021/bi00649a026Search in Google Scholar

Hjertén S, Pan H. Purification and characterization of two forms of a low-affinity Ca2+-ATPase from erythrocyte membranes. Biochem Biophys Acta. 1983; 728:281–8.HjerténSPanHPurification and characterization of two forms of a low-affinity Ca2+-ATPase from erythrocyte membranesBiochem Biophys Acta1983728281810.1016/0005-2736(83)90480-7Search in Google Scholar

White MD and Ralston GB. Purification of water soluble Mg2+ ATPase from human erythrocyte membranes. Biochem Biophys Acta. 1980; 599:569–79.WhiteMDRalstonGBPurification of water soluble Mg2+ ATPase from human erythrocyte membranesBiochem Biophys Acta19805995697910.1016/0005-2736(80)90200-XSearch in Google Scholar

Deng M, Zha J, Jiang Z, Jia X, Shi Y, Li P, et al. Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia. J Transl Med. 2018; 16:47. doi:10.1186/s12967-018-1421-yDengMZhaJJiangZJiaXShiYLiPApatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemiaJ Transl Med2018164710.1186/s12967-018-1421-y583185229490645Open DOISearch in Google Scholar

Guo J, Zhang Y, Zhang J, Liang J, Zeng L, Guo G. Anticancer effect of tert-butyl-2(4,5-dihydrogen-4,4,5,5-tetramethyl-3-O-1H-imidazole-3-cationic-1-oxyl-2)-pyrrolidine-1-carboxylic ester on human hepatoma HepG2 cell line. Chem Biol Interact. 2012; 199:38–48.GuoJZhangYZhangJLiangJZengLGuoGAnticancer effect of tert-butyl-2(4,5-dihydrogen-4,4,5,5-tetramethyl-3-O-1H-imidazole-3-cationic-1-oxyl-2)-pyrrolidine-1-carboxylic ester on human hepatoma HepG2 cell lineChem Biol Interact2012199384810.1016/j.cbi.2012.06.00122704995Search in Google Scholar

Kamal A, Hussaini SMA, Malik MS. Recent developments towards podophyllotoxin congeners as potential apoptosis inducers. Anticancer Agents Med Chem. 2015; 15:565–74.KamalAHussainiSMAMalikMSRecent developments towards podophyllotoxin congeners as potential apoptosis inducersAnticancer Agents Med Chem2015155657410.2174/187152061466614113012562325469512Search in Google Scholar

Wang C, Youle RJ. The role of mitochondria in apoptosis. Annu Rev Genet. 2009; 43:95–118.WangCYouleRJThe role of mitochondria in apoptosisAnnu Rev Genet2009439511810.1146/annurev-genet-102108-134850476202919659442Search in Google Scholar

Majtnerová P, Roušar T. An overview of apoptosis assays detecting DNA fragmentation. Mol Biol Rep. 2018; 45:1469–78.MajtnerováPRoušarTAn overview of apoptosis assays detecting DNA fragmentationMol Biol Rep20184514697810.1007/s11033-018-4258-930022463Search in Google Scholar

Babes RM, Tofolean IT, Sandu RG, Baran OE, Cosoreanu V, Ilie MT, et al. Simple discrimination of sub-cycling cells by propidium iodide flow cytometric assay in Jurkat cell samples with extensive DNA fragmentation. Cell Cycle. 2018; 17:766–79.BabesRMTofoleanITSanduRGBaranOECosoreanuVIlieMTSimple discrimination of sub-cycling cells by propidium iodide flow cytometric assay in Jurkat cell samples with extensive DNA fragmentationCell Cycle2018177667910.1080/15384101.2018.1426415Search in Google Scholar

Lopez J, Tait SW. Mitochondrial apoptosis: killing cancer using the enemy within. Br J Cancer. 2015; 112:957–62.LopezJTaitSWMitochondrial apoptosis: killing cancer using the enemy withinBr J Cancer20151129576210.1038/bjc.2015.85Search in Google Scholar

Gassbarini A, Borle AB, Faghali H, Bender C, Francavilla A, Van Thiel D. Effect of anoxia on intracellular ATP, Na+i, Ca2+i, Mg2+i, and cytotoxicity in rat hepatocytes. J Biol Chem. 1994; 267: 6654–63.GassbariniABorleABFaghaliHBenderCFrancavillaAVan ThielDEffect of anoxia on intracellular ATP, Na+i, Ca2+i, Mg2+i, and cytotoxicity in rat hepatocytesJ Biol Chem199426766546310.1016/S0021-9258(19)50477-XSearch in Google Scholar

eISSN:
1875-855X
Language:
English
Publication timeframe:
6 times per year
Journal Subjects:
Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine