Open Access

Proportion of vulvar premalignant and malignant lesions in overall vulvar specimens in Thailand

Ananya Trongpisutsak
Ananya Trongpisutsak
, 
Patou Tantbirojn
Patou Tantbirojn
 and 
Ruangsak Lertkhachonsuk
Ruangsak Lertkhachonsuk
   | Oct 24, 2019
Asian Biomedicine's Cover Image
About this article
Previous Article
Next Article
Cite
Article Category: Brief communication (original)
Published Online: Oct 24, 2019
Page range: 281 - 286
DOI: https://doi.org/10.1515/abm-2019-0031
Keywords
© 2018 Ananya Trongpisutsak et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Figure 1

Proportion of premalignant and malignant lesions in each age group.
Proportion of premalignant and malignant lesions in each age group.

Figure 2

Proportion of premalignant and malignant lesions in premenopause and menopause group.
Proportion of premalignant and malignant lesions in premenopause and menopause group.

Figure 3

Proportion of premalignant and malignant lesions in different parity.
Proportion of premalignant and malignant lesions in different parity.

Figure 4

Proportion of premalignant and malignant lesions in each location.
Proportion of premalignant and malignant lesions in each location.

Figure 5

Proportion of premalignant and malignant lesions in different lesion size.
Proportion of premalignant and malignant lesions in different lesion size.

Figure 6

Proportion of premalignant and malignant lesions in different lesion colors.
Proportion of premalignant and malignant lesions in different lesion colors.

Patient’s demographic characteristics

Demographic dataBenign (n = 527)Premalignant (n = 59)Malignant (n = 114)P*
Age (mean ± SD)45.1 ± 15.652.9 ± 14.556.9 ± 16.6<0.001**
Parity (%)
0192 (36.4)13 (22.1)21 (18.4)<0.001**
1159 (30.2)14 (23.7)17 (14.9)0.002**
2106 (20.1)16 (27.1)23 (20.2)0.494
>270 (13.3)16 (27.1)53 (46.5)<0.001**
Postmenopause (%)181 (34.3)38 (64.4)74 (64.9)<0.001**
Presenting symptom (%)
Mass425 (80.6)24 (40.7)86 (75.4)<0.001**
Rash73 (13.8)28 (47.5)24 (21.1)<0.001**
Itching29 (5.6)7 (11.8)4 (3.5)0.674

Lesion characteristics

Demographic dataBenign (n = 527)Premalignant (n = 59)Malignant (n = 114)P*
Location (%)
Labia majora273 (51.9)37 (62.7)57 (50.0)0.240
Labia minora122 (23.1)10 (16.9)24 (21.1)0.523
Mon pubis47 (8.9)3 (5.1)9 (7.8)0.558
Anterior fourchette30 (5.7)6 (10.2)6 (5.3)0.365
Bartholin’s gland36 (6.8)0 (0)2 (1.8)0.015
Clitoris9 (1.7)2 (3.4)14 (12.2)<0.001**
Posterior fourchette10 (1.9)1 (1.7)2 (1.8)0.990
Size (cm) (%)
≤2 cm434 (82.4)21 (35.6)23 (20.2)<0.001**
>2–4 cm71 (13.5)24 (40.7)44 (38.6)<0.001**
>4 cm22 (4.1)14 (23.4)47 (41.2)<0.001**
Color (%)
Unchanged skin color364 (69.1)44 (74.6)29 (25.4)<0.001**
Hypopigment111 (21.1)8 (13.5)47 (41.2)0.004**
Erythematous26 (4.9)7 (11.9)28 (24.6)<0.001**
Hyperpigment26 (4.9)0 (0)10 (8.8)0.662

Univariate and multivariate analysis to predict vulvar malignancy risk

FactorsUnivariate analysisMultivariate analysis
OR95% CIPOR95% CIP
Age (years)1.041.03–1.05<0.001*1.000.97–1.020.890
Menopause (yes, no)3.512.45–5.03<0.001*1.830.83–4.050.130
Parity (times)1.411.28–1.56<0.001*1.191.04–1.360.010*
Size (cm)2.101.84–2.40<0.001*2.001.73–2.31<0.001*
Location
Labia majora6.191.46–26.230.013*3.260.72–14.70.130
Labia minora5.021.14–21.890.032*4.200.91–19.60.070
Clitoris32.006.19–165.2<0.001*15.672.72–90.90.002*
Color
Hyperpigment1.920.89–4.150.0982.380.94–6.060.068
Hypopigment2.471.64–3.72<0.001*1.140.68–1.910.625
Erythematous6.713.81–11.83<0.001*2.411.11–5.240.026*

Trends of vulvar premalignant and malignant lesions

Year 2002–2008 (n = 342)Year 2009–2015 (n = 358)P
Malignant vulvar lesion45 (13.2%)69 (19.3%)0.028*
Premalignant vulvar lesion25 (7.3%)34 (9.5%)0.298

Diagnosis of vulvar lesion in number and percentage

Malignant (n = 114)Benign (n = 527)
Squamous cell55 (48.2)Fibroepithelial polyp126 (23.9)
carcinoma
Malignant melanoma12 (10.5)Epidermal inclusion cyst84 (15.9)
Adenocarcinoma10 (8.8)Inflammation72 (13.7)
Invasive Paget’s8 (7.0)Condyloma acumi-52 (9.9)
diseasenata
Soft tissue tumors7 (6.2)Seborrheic keratosis26 (4.9)
Verrucous carcinoma5 (4.4)Nevus22 (4.2)
Basal cell carcinoma4 (3.5)Hydradenoma17 (3.2)
papilliferum
Neuroendocrine4 (3.5)Lichen sclerosus15 (2.8)
tumors
Others9 (7.9)Hyperkeratosis12 (2.3)
Lipoma10 (1.9)
Premalignant (n = 59)Others91 (17.3)
VIN120 (33.9)
VIN319 (32.2)
Paget’s disease16 (27.1)
VIN24 (6.8)
eISSN:
1875-855X
Language:
English
Publication timeframe:
6 times per year
Journal Subjects:
Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine
Journal RSS Feed