Elevation of serum adiponectin in mildly decreased glomerular filtration rate

Apinya Mahima; Sudawadee Kongkhum; Narisa Kengtong Bordeerat; Somsak Fongsupa; Thaval Rerksngarm; Pilaiwan Siripurkpong

Open Access

Elevation of serum adiponectin in mildly decreased glomerular filtration rate

Apinya Mahima

Sudawadee Kongkhum

Narisa Kengtong Bordeerat

Somsak Fongsupa

Thaval Rerksngarm

and

Pilaiwan Siripurkpong

| Oct 24, 2019

Asian Biomedicine

Volume 12 (2018): Issue 6 (December 2018)

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Published Online: Oct 24, 2019

Page range: 255 - 262

DOI: https://doi.org/10.1515/abm-2019-0028

Keywords
adiponectin, chronic, glomerular filtration rate, renal insufficiency

© 2018 Apinya Mahima et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Comparison of the serum adiponectin between the mildly decreased eGFR (G2) and the control with normal eGFR (G1). P: Mann–Whiney U test

Comparison of serum adiponectin in male (open bars) and female (solid bars) in the mildly decreased eGFR (G2) and the control with normal eGFR (G1). P: Mann–Whiney U test

Comparison of serum adiponectin between the normal eGFR (gray bar) and the mildly decreased eGFR (black bar) among normal weight, overweight, and obesity based on Asian BMI. The Kruskal–Wallis test followed by a post-hoc test was used to determine the differences between three independent groups and all pairwise comparisons. (*P < 0.05 vs normal weight group and obese group and overweight group and obese group)

Anthropometric characteristics and biochemical variables of the mildly decreased eGFR (G2) and the normal eGFR (G1)

Variables	Normal eGFR (G1)	Mildly decreased eGFR (G2)	P
	(n = 90)	(n = 82)
Sex
Male, n (%)	14 (16)	22 (27)
Female, n (%)	76 (84)	60 (73)	0.069^a
Age (years)	43.52 ± 5.92	50.17 ± 6.42	<0.001*^b
Weight (kg)	63.53 ± 12.36	62.24 ± 9.99	0.760^b
Body mass index (kg/m²)	24.697 ± 3.87	24.09 ± 3.10	0.624^b
Waist (cm)	82.56 ± 10.14	83.72 ± 8.35	0.278^b
Hip (cm)	98.94 ± 8.91	97.54 ± 7.50	0.331^b
Waist-to-hip ratio	0.84 ± 0.07	0.86 ± 0.06	0.062^b
DBP (mmHg)	75.89 ± 9.33	80.20 ± 10.34	<0.001*^b
SBP (mmHg)	116.28 ± 12.46	124.32 ± 13.25	<0.001*^b
Body adipose	30.98 ± 4.88	30.20 ± 4.96	0.274^b
Creatinine (mg/dL)	0.70 ± 0.11	0.92 ± 0.14	<0.001*^b
eGFR	105.02 ± 8.33	80.20 ± 6.98	<0.001*^b
UACR (mg/g)	6.71 ± 4.27	8.13 ± 9.39	0.582^b
FPG (mg/dL)	88.44 ± 6.56	88.91 ± 6.97	0.630^b
Cholesterol (mg/dL)	225.56 ± 50.23	229.27 ± 45.45	0.480^b
Triglyceride (mg/dL)	113.42 ± 54.58	125.43 ± 69.30	0.321^b
HDL-C (mg/dL)	54.29 ± 14.54	60.61 ± 15.16	0.012*^b
LDL-C (mg/dL)	144.36 ± 38.66	143.45 ± 40.13	0.800^b
Serum adiponectin (mg/mL)	6.57 ± 3.24	8.23 ± 3.26	<0.001*^b

Multiple linear regression with adiponectin as a dependent variable (N = 172)

Independent variables	Unstandardized coefficients		Standardized coefficients	t	P < 0.05
Independent variables	B	Std. Error	Beta	t	P < 0.05
Constant	22.190	36.021		0.616	0.539
Age (year)	0.117	0.052	0.244	2.248	0.026*
Weight (kg)	0.244	0.247	0.822	0.989	0.324
BMI (kg/m²)	–0.595	0.643	–0.627	–0.926	0.356
Waist (cm)	–0.078	0.264	–0.216	–0.295	0.769
Hip (cm)	–0.094	0.343	–0.233	–0.275	0.784
Waist-to-hip ratio	3.976	24.328	0.084	0.163	0.870
DBP (mmHg)	–0.050	0.032	–0.150	–1.534	0.127
SBP (mmHg)	0.019	0.025	0.077	0.783	0.435
Body adiposity index	0.182	0.485	0.268	0.375	0.708
Creatinine (mg/dL)	–1.451	4.985	–0.073	–0.291	0.771
eGFR	–0.030	0.053	–0.129	–0.562	0.575
UACR (mg/g)	0.021	0.031	0.045	0.664	0.508
FPG (mg/dL)	0.054	0.035	0.108	1.554	0.122
Cholesterol (mg/dL)	0.020	0.011	0.289	1.909	0.058
Triglyceride (mg/dL)	–0.006	0.005	–0.103	–1.152	0.251
HDL-C (mg/dL)	0.053	0.020	0.241	2.651	0.009*
LDL-C (mg/dL)	–0.030	0.012	–0.351	–2.537	0.012*
Constant = 22.190; R = 0.600; R² = 0.280; SE_est= ±2.82; F = 4.494; P <0.05

Univariate and multivariate analyses of risk for mildly decreased eGFR

Variables	Case	Control	Crude OR	P	Adjusted OR	P
	N (%)	N (%)	(95%Cl)		(95%Cl)
Sex
Male	22 (26.8)	14 (15.6)	1
Female	60 (73.2)	76 (84.4)	0.5 (0.2–1.1)	0.072
Age (years)
35–45	20 (24.4)	60 (66.7)	1		1
46–55	38 (46.3)	25 (27.8)	4.5 (2.2–9.3)	<0.001*	4.0 (1.9–8.3)	<0.001*
>55	24 (29.3)	5 (5.5)	14.4 (4.9–42.8)	<0.001*	11.4 (3.7–35.5)	<0.001*
Body mass index (kg/m²)
Normal	30 (36.6)	30 (33.3)	1
Overweight	27 (37.9)	30 (33.3)	0.9 (0.4–1.9)	0.776
Obese	25 (30.5)	30 (33.3)	0.8 (0.4–1.7)	0.626
Waist-to-hip ratio
Male ≤0.90, Female ≤0.85	52 (63.4)	63 (70.0)	1
Male >0.90, Female >0.85	30 (36.6)	27 (30.0)	1.3 (0.7–2.5)	0.360
SBP (mmHg)
<130	57 (69.5)	77 (85.6)	1		1
≥130	25 (30.5)	13 (14.4)	2.6 (1.2–5.5)	0.013*	1.2 (0.4–3.4)	0.689
DBP (mmHg)
<85	53 (64.6)	75 (83.3)	1		1
≥85	29 (35.4)	15 (16.7)	2.7 (1.4–5.9)	0.006*	2.2 (0.8–5.5)	0.112
Glucose (mg/dL)
<100	78 (95.1)	89 (5.6)	1
≥100	4 (4.9)	1 (1.1)	4.5 (0.5–41.7)	0.179
Cholesterol (mg/dL)
<200	18 (22.0)	28 (31.1)	1
≥200	64 (78.0)	62 (68.9)	1.6 (0.8–3.2)	0.177
Triglyceride (mg/dL)
<150	58 (70.7)	71 (78.9)	1
≥150	24 (29.3)	19 (21.1)	1.5 (0.8–3.1)	0.219
HDL-C (mg/dL)
Male ≥40, Female ≥50	14 (17.1)	23 (25.6)	1
Male <40, Female <50	68.6 (82.9)	67 (74.4)	1.6 (0.8–3.5)	0.179
LDL-C (mg/dL)
<100	11 (12.6)	9 (10.0)	1
≥100	76 (87.4)	81 (90.0)	0.8 (0.3–2.1)	0.647
Serum adiponectin (mg/mL)
<5.70	24 (29.3)	45 (50.0)	1		1
≥5.70	58 (70.7)	45 (50.0)	2.4 (1.3–4.5)	0.006*	1.7 (0.8–3.5)	0.147

Bivariate spearman’s rank correlation coefficients between serum adiponectin with anthropometric characteristics and biochemical variables

Variables	Serum adiponectin (µg/mL)
	r	P
Age (year)	0.355	<0.001*
Weight (kg)	-0.306	<0.001*
Body mass index (kg/m²)	-0.217	0.004*
Waist (cm)	-0.236	0.002*
Hip (cm)	-0.256	0.001*
Waist-to-hip ratio	-0.105	0.168
DBP (mmHg)	-0.071	0.358
SBP (mmHg)	0.004	0.963
Body adiposity index	-0.068	0.379
Creatinine (mg/dL)	-0.073	0.344
eGFR	-0.257	0.001*
UACR (mg/g)	0.108	0.159
FPG (mg/dL)	-0.005	0.947
Cholesterol (mg/dL)	-0.056	0.469
Triglyceride (mg/dL)	-0.204	0.007*
HDL-C (mg/dL)	0.444	<0.001*
LDL-C (mg/dL)	-0.082	0.283

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Elevation of serum adiponectin in mildly decreased glomerular filtration rate

Article Category: Original article

Published Online: Oct 24, 2019

Page range: 255 - 262

DOI: https://doi.org/10.1515/abm-2019-0028

Keywords
adiponectin, chronic, glomerular filtration rate, renal insufficiency

© 2018 Apinya Mahima et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Figure 1

Figure 2

Figure 3

Anthropometric characteristics and biochemical variables of the mildly decreased eGFR (G2) and the normal eGFR (G1)

Multiple linear regression with adiponectin as a dependent variable (N = 172)

Univariate and multivariate analyses of risk for mildly decreased eGFR

Bivariate spearman’s rank correlation coefficients between serum adiponectin with anthropometric characteristics and biochemical variables

Elevation of serum adiponectin in mildly decreased glomerular filtration rate

Article Category: Original article

Published Online: Oct 24, 2019

Page range: 255 - 262

DOI: https://doi.org/10.1515/abm-2019-0028

Keywordsadiponectin, chronic, glomerular filtration rate, renal insufficiency

© 2018 Apinya Mahima et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Figure 1

Figure 2

Figure 3

Anthropometric characteristics and biochemical variables of the mildly decreased eGFR (G2) and the normal eGFR (G1)

Multiple linear regression with adiponectin as a dependent variable (N = 172)

Univariate and multivariate analyses of risk for mildly decreased eGFR

Bivariate spearman’s rank correlation coefficients between serum adiponectin with anthropometric characteristics and biochemical variables

Keywords
adiponectin, chronic, glomerular filtration rate, renal insufficiency