Open Access

Evaluation of SHP1-P2 methylation as a biomarker of lymph node metastasis in patients with squamous cell carcinoma of the head and neck


Cite

Figure 1

SHP1-P2 methylation. (A) Percentage of SHP1-P2 methylation comparisons in the 5 sample groups. (B) Comparison of LN– Nx and LN+ Nx. A significant difference was observed between LN– Nx and LN+ Nx (P < 0.0001). (C) ROC curve analysis to distinguish LN N0 from LN– Nx. The curve showed AUC = 0.637 with a sensitivity of 66.67% and a specificity of 60%. AUC, area under the curve; HNSCC, squamous cell carcinoma of the head and neck; LN N0, nonmetastatic HNSCC lymph nodes; LN–Nx = lymph nodes that are histologically negative for tumor cells in patients with metastatic HNSCC; LN+ Nx, lymph nodes that are histologically positive for tumor cells in metastatic HNSCC; ROC, receiver operating characteristic; SCC, squamous cell carcinoma; SHP1-P2, Src homology region 2 domain-containing protein-tyrosine phosphatase 1 promoter 2 patients with
SHP1-P2 methylation. (A) Percentage of SHP1-P2 methylation comparisons in the 5 sample groups. (B) Comparison of LN– Nx and LN+ Nx. A significant difference was observed between LN– Nx and LN+ Nx (P < 0.0001). (C) ROC curve analysis to distinguish LN N0 from LN– Nx. The curve showed AUC = 0.637 with a sensitivity of 66.67% and a specificity of 60%. AUC, area under the curve; HNSCC, squamous cell carcinoma of the head and neck; LN N0, nonmetastatic HNSCC lymph nodes; LN–Nx = lymph nodes that are histologically negative for tumor cells in patients with metastatic HNSCC; LN+ Nx, lymph nodes that are histologically positive for tumor cells in metastatic HNSCC; ROC, receiver operating characteristic; SCC, squamous cell carcinoma; SHP1-P2, Src homology region 2 domain-containing protein-tyrosine phosphatase 1 promoter 2 patients with

Percentage of SHP1-P2 methylation

GroupnSHP1-P2 methylation (%, mean ± SD)
Tonsil1010.27 ± 4.05
LN N0159.99 ± 6.61
LN– Nx1814.49 ± 10.03
LN+ Nx1841.01 ± 24.51
SCC961.31 ± 17.00

Demographic data of patients with squamous cell carcinoma of the head and neck (HNSCC)

SexAge (y)OrganHistological gradeClinical stage
Microdissected HNSCC
M51Floor of mouth22
F62Tongue11
M65Floor of mouth23
F62Tongue31
M67Gingiva12
M50Gingiva12
M61Tongue24
M37Tongue22
M56Tongue34
N0 (no metastasis)
11MTongue24
67FBuccal mucosa13
47FTongue12
53FTongue11
51MFloor of mouth23
83FLip24
70MSoft palate13
48FSoft palate14
72MPalate22
38FTongue22
46FTongue11
65MBuccal mucosa23
81MTongue21
72FBuccal mucosa22
63MTongue21
Nx (metastasis)
52MTongue11
57MSoft palate33
54MSoft palate24
56MTongue24
79FPalate34
74MBuccal mucosa14
42MTongue34
66MSoft palate24
51MTongue24
66FBuccal mucosa12
58MTongue24
67MTongue24
60MBuccal mucosa14
69MGingiva24
34MTongue14
64FTongue23
61MSoft palate23
84FLower lip24
eISSN:
1875-855X
Language:
English
Publication timeframe:
6 times per year
Journal Subjects:
Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine