<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_abm-2018-0016_s_008_w2aab3b7b3b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Depression is a neuroprogressive disorder that is characterized by neurotransmitter derangement and decreased neurogenesis and neurotrophic factors including brain-derived neurotrophic factor (BDNF).</p></sec><sec id="j_abm-2018-0016_s_009_w2aab3b7b3b1b6b1aab1c16b2Aa"><h3>Objectives</h3><p>To determine the lipid profiles and BDNF levels in university students at an institution in Iran and association of these factors with Beck Depression Inventory (BDI) scores.</p></sec><sec id="j_abm-2018-0016_s_010_w2aab3b7b3b1b6b1aab1c16b3Aa"><h3>Methods</h3><p>We conducted an observational study of a cross-section of male students at the Ahvaz Jundishapur University of Medical Sciences in Iran. For each of the 100 participants, a BDI score was obtained and serum levels of BDNF were measured by enzyme-linked immunosorbent assay. Levels of serum lipids, including cholesterol, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were measured using a biochemical analyzer. Castelli’s risk index type I (CRI-I), Castelli’s risk index type II (CRI-II), CRI-I = TG/HDL-C and CRI-II = LDL-cholesterol/ HDL-cholesterol, and atherogenic index of plasma (AIP), AIP = log (triglycerides/HDL-cholesterol), were calculated.</p></sec><sec id="j_abm-2018-0016_s_011_w2aab3b7b3b1b6b1aab1c16b4Aa"><h3>Results</h3><p>Based on BDI scores, lower levels of BDNF, triglycerides, cholesterol, and HDL, but higher levels of LDL were found in participants with higher BDI scores. CRI-I was also increased in participants with depression.</p></sec><sec id="j_abm-2018-0016_s_012_w2aab3b7b3b1b6b1aab1c16b5Aa"><h3>Conclusion</h3><p>The levels of BDNF and lipid factors are associated with the severity of depression in Iranian male university students. Deranged levels of BDNF and lipids may predispose depressed students to cardiovascular diseases.</p></sec></abstract>

BackgroundDepression is a neuroprogressive disorder that is characterized by neurotransmitter derangement and decreased neurogenesis and neurotrophic factors including brain-derived neurotrophic factor (BDNF).ObjectivesTo determine the lipid profiles and BDNF levels in university students at an institution in Iran and association of these factors with Beck Depression Inventory (BDI) scores.MethodsWe conducted an observational study of a cross-section of male students at the Ahvaz Jundishapur University of Medical Sciences in Iran. For each of the 100 participants, a BDI score was obtained and serum levels of BDNF were measured by enzyme-linked immunosorbent assay. Levels of serum lipids, including cholesterol, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were measured using a biochemical analyzer. Castelli’s risk index type I (CRI-I), Castelli’s risk index type II (CRI-II), CRI-I = TG/HDL-C and CRI-II = LDL-cholesterol/ HDL-cholesterol, and atherogenic index of plasma (AIP), AIP = log (triglycerides/HDL-cholesterol), were calculated.ResultsBased on BDI scores, lower levels of BDNF, triglycerides, cholesterol, and HDL, but higher levels of LDL were found in participants with higher BDI scores. CRI-I was also increased in participants with depression.ConclusionThe levels of BDNF and lipid factors are associated with the severity of depression in Iranian male university students. Deranged levels of BDNF and lipids may predispose depressed students to cardiovascular diseases.

Serum lipids and brain-derived neurotrophic factor in a cross-section of male students with symptoms of depression at a university in Iran: an observational study

Department of Biochemistry, School of Medicine

Ahvaz Jundishapur University of Medical Sciences

Department of Medical Laboratory Sciences

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

BackgroundDepression is a neuroprogressive disorder that is characterized by neurotransmitter derangement and decreased neurogenesis and neurotrophic factors...

Serum lipids and brain-derived neurotrophic factor in a cross-section of male students with symptoms of depression at a university in Iran: an observational study

Article Category: Original article

Published Online: Oct 10, 2018

Page range: 413 - 417

DOI: https://doi.org/10.1515/abm-2018-0016

Keywords
BDNF, Beck Depression Inventory, depression, lipid profile

© 2017 Ramin Tavakoli et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Serum lipids and brain-derived neurotrophic factor in a cross-section of male students with symptoms of depression at a university in Iran: an observational study

Article Category: Original article

Published Online: Oct 10, 2018

Page range: 413 - 417

DOI: https://doi.org/10.1515/abm-2018-0016

KeywordsBDNF, Beck Depression Inventory, depression, lipid profile

© 2017 Ramin Tavakoli et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
BDNF, Beck Depression Inventory, depression, lipid profile