<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><bold>Background.</bold> The aim of this study was to investigate the antitumor effectiveness of electrochemotherapy with cis-platin combined with suboptimal radiotherapy doses. Tumor radiosensitization was evaluated on large invasive ductal carcinoma tumors in Balb/C mice.<bold>Materials and methods.</bold> Tumors of an average volume of 630 mm3 were treated with cisplatin, electric pulses, radiotherapy, electrochemotherapy, alone as well as in appropriate combinations. Tumors were irradiated with Cobalt-60 γ-rays at doses 3 Gy and 5 Gy in combination with electrochemotherapy using cisplatin. Controls included each of the treatments alone as well as the combination of the radiotherapy with electric pulses alone or with cisplatin alone. Antitumor effectiveness was evaluated by tumor growth delay, tumor-doubling time, inhibition ratio and the objective response rates.<bold>Results.</bold> As anticipated, electrochemotherapy was more effective than the treatment with cisplatin alone or the application of the electric pulses alone. When treatments were combined with tumor irradiation at either 3 or 5 Gy, the combination with electrochemotherapy was more effective: at 5 Gy, 2 animals out of 8 were in complete remission 100 days later. In general the higher 5 Gy dose of γ-radiation was more effective than the lower one of 3 Gy.<bold>Conclusions.</bold> The results of our study demonstrate that irradiation doses, 3 Gy or 5 Gy, increase the antitumor effectiveness of electrochemotherapy with cisplatin on invasive ductal carcinoma tumors. Good antitumor results were achieved in experimental tumors with a size comparable to clinical lesions, demonstrating that this three-modality combined treatment is useful for the treatment of large lesions even at sub-optimal radiotherapy doses.</abstract>

Background. The aim of this study was to investigate the antitumor effectiveness of electrochemotherapy with cis-platin combined with suboptimal radiotherapy doses. Tumor radiosensitization was evaluated on large invasive ductal carcinoma tumors in Balb/C mice.Materials and methods. Tumors of an average volume of 630 mm3 were treated with cisplatin, electric pulses, radiotherapy, electrochemotherapy, alone as well as in appropriate combinations. Tumors were irradiated with Cobalt-60 γ-rays at doses 3 Gy and 5 Gy in combination with electrochemotherapy using cisplatin. Controls included each of the treatments alone as well as the combination of the radiotherapy with electric pulses alone or with cisplatin alone. Antitumor effectiveness was evaluated by tumor growth delay, tumor-doubling time, inhibition ratio and the objective response rates.Results. As anticipated, electrochemotherapy was more effective than the treatment with cisplatin alone or the application of the electric pulses alone. When treatments were combined with tumor irradiation at either 3 or 5 Gy, the combination with electrochemotherapy was more effective: at 5 Gy, 2 animals out of 8 were in complete remission 100 days later. In general the higher 5 Gy dose of γ-radiation was more effective than the lower one of 3 Gy.Conclusions. The results of our study demonstrate that irradiation doses, 3 Gy or 5 Gy, increase the antitumor effectiveness of electrochemotherapy with cisplatin on invasive ductal carcinoma tumors. Good antitumor results were achieved in experimental tumors with a size comparable to clinical lesions, demonstrating that this three-modality combined treatment is useful for the treatment of large lesions even at sub-optimal radiotherapy doses.

The antitumor efficiency of combined electrochemotherapy and single dose irradiation on a breast cancer tumor model

Department of Medical Physics, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran

Faculty of Science, University of Geneve, Geneve, Switzerland

Division of Radiation Medicine, Shahid Beheshti University, Tehran, Iran

Department of Immunohematology, Research Center of Iranian Blood Transfusion Organization (IBTO), Tehran, Iran

CNRS, Orsay, Laboratoire de Vectorologie et Therapeutiques Anticancereuses, UMR 8203, 91405 Orsay cedex, France

Laboratoire de Vectorologie et Therapeutiques Anticancereuses, Universite Paris-Sud, UMR 8203, 91405 Orsay cedex, France

Institute Gustave Roussy, Laboratoire de Vectorologie et Therapeutiques Anticancereuses, UMR 8203, 114 rue E. Vaillant, 94805 Villejuif cedex, France

Radiology and Oncology

Background. The aim of this study was to investigate the antitumor effectiveness of electrochemotherapy with cis-platin combined with suboptimal radiotherapy...

The antitumor efficiency of combined electrochemotherapy and single dose irradiation on a breast cancer tumor model

Published Online: Jun 19, 2012

Page range: 226 - 232

DOI: https://doi.org/10.2478/v10019-012-0035-x

Keywords
cisplatin, irradiation, electroporation, invasive ductal carcinoma, multimodalities

This content is open access.

The antitumor efficiency of combined electrochemotherapy and single dose irradiation on a breast cancer tumor model

Published Online: Jun 19, 2012

Page range: 226 - 232

DOI: https://doi.org/10.2478/v10019-012-0035-x

Keywordscisplatin, irradiation, electroporation, invasive ductal carcinoma, multimodalities

This content is open access.

Keywords
cisplatin, irradiation, electroporation, invasive ductal carcinoma, multimodalities