This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Des Guetz G, Landre T, Bollet MA, Mathonnet M, Quéro L. Is There a Benefit of Oxaliplatin in Combination with Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer? An Updated Meta-Analysis. Cancers (Basel). 2021 Nov 30;13(23):6035.Des GuetzGLandreTBolletMAMathonnetMQuéroLIs There a Benefit of Oxaliplatin in Combination with Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer? An Updated Meta-Analysis2021Nov3013236035Search in Google Scholar
Petrelli F, Coinu A, Lonati V, Barni S. A systematic review and meta-analysis of adjuvant chemotherapy after neoadjuvant treatment and surgery for rectal cancer. Int J Colorectal Dis. 2015 Apr;30(4):447–57.PetrelliFCoinuALonatiVBarniSA systematic review and meta-analysis of adjuvant chemotherapy after neoadjuvant treatment and surgery for rectal cancer2015Apr30444757Search in Google Scholar
Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, et al. Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2018 Jul;16(7):874–901.BensonABVenookAPAl-HawaryMMCederquistLChenYJCiomborKKRectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology2018Jul167874901Search in Google Scholar
Chaft JE, Rimner A, Weder W, Azzoli CG, Kris MG, Cascone T. Evolution of systemic therapy for stages I-III non-metastatic non-small-cell lung cancer. Nat Rev Clin Oncol. 2021 Sep;18(9):547–57.ChaftJERimnerAWederWAzzoliCGKrisMGCasconeTEvolution of systemic therapy for stages I-III non-metastatic non-small-cell lung cancer2021Sep18954757Search in Google Scholar
Wang H, Mao X. Evaluation of the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer. Drug Des Devel Ther. 2020;14:2423–33.WangHMaoXEvaluation of the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer202014242333Search in Google Scholar
Yin M, Joshi M, Meijer RP, Glantz M, Holder S, Harvey HA, et al. Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer: A Systematic Review and Two-Step Meta-Analysis. Oncologist. 2016 Jun;21(6):708–15.YinMJoshiMMeijerRPGlantzMHolderSHarveyHANeoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer: A Systematic Review and Two-Step Meta-Analysis2016Jun21670815Search in Google Scholar
Coccolini F, Nardi M, Montori G, Ceresoli M, Celotti A, Cascinu S, et al. Neoadjuvant chemotherapy in advanced gastric and esophago-gastric cancer. Meta-analysis of randomized trials. Int J Surg. 2018 Mar;51:120–7.CoccoliniFNardiMMontoriGCeresoliMCelottiACascinuSNeoadjuvant chemotherapy in advanced gastric and esophago-gastric cancer. Meta-analysis of randomized trials2018Mar511207Search in Google Scholar
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EMK, et al. Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial. Lancet Oncol. 2021 Jan;22(1):29–42.BahadoerRRDijkstraEAvan EttenBMarijnenCAMPutterHKranenbargEMKShort-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial2021Jan2212942Search in Google Scholar
Conroy T, Bosset JF, Etienne PL, Rio E, François É, Mesgouez-Nebout N, et al. Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2021 Dec;22(5):702–15.ConroyTBossetJFEtiennePLRioEFrançoisÉMesgouez-NeboutNNeoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial2021Dec22570215Search in Google Scholar
Ciseł B, Pietrzak L, Michalski W, Wyrwicz L, Rutkowski A, Kosakowska E, et al. Long-course preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study. Ann Oncol. 2019 Aug 1;30(8):1298–303.CisełBPietrzakLMichalskiWWyrwiczLRutkowskiAKosakowskaELong-course preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study2019Aug13081298303Search in Google Scholar
Jin J, Tang Y, Hu C, Jiang LM, Jiang J, Li N, et al. Multicenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR). J Clin Oncol. 2022 Dec 20;40(15):1681–92.JinJTangYHuCJiangLMJiangJLiNMulticenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR)2022Dec204015168192Search in Google Scholar
Fokas E, Schlenska-Lange A, Polat B, Klautke G, Grabenbauer GG, Fietkau R, et al. Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer: Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial. JAMA Oncol. 2022 Jan 1;8(1):e215445.FokasESchlenska-LangeAPolatBKlautkeGGrabenbauerGGFietkauRChemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer: Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial2022Jan181e215445Search in Google Scholar
Garcia-Aguilar J, Patil S, Gollub MJ, Kim JK, Yuval JB, Thompson HM, et al. Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy. J Clin Oncol. 2022 Aug 10;40(23):2546–56.Garcia-AguilarJPatilSGollubMJKimJKYuvalJBThompsonHMOrgan Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy2022Aug104023254656Search in Google Scholar
Conroy T, Etienne PL, Rio E, Evesque L, Mesgouez-Nebout N, Vendrely V, et al. Total neoadjuvant therapy with mFOLFIRINOX versus preoperative chemoradiation in patients with locally advanced rectal cancer: 7-year results of PRODIGE 23 phase III trial, a UNICANCER GI trial. JCO. 2023 Jun 10;41(17_suppl):LBA3504–LBA3504.ConroyTEtiennePLRioEEvesqueLMesgouez-NeboutNVendrelyVTotal neoadjuvant therapy with mFOLFIRINOX versus preoperative chemoradiation in patients with locally advanced rectal cancer: 7-year results of PRODIGE 23 phase III trial, a UNICANCER GI trial2023Jun104117_supplLBA3504LBA3504Search in Google Scholar
Bujko K, on behalf of the Polish Colorectal Study Group. Neoadjuvant chemoradiation for fixed cT3 or cT4 rectal cancer: Results of a Polish II multicentre phase III study. JCO. 2016 Feb 1;34(4_suppl):489–489.BujkoKon behalf of the Polish Colorectal Study GroupNeoadjuvant chemoradiation for fixed cT3 or cT4 rectal cancer: Results of a Polish II multicentre phase III study2016Feb1344_suppl489489Search in Google Scholar
Schrag D, Shi Q, Weiser MR, Gollub MJ, Saltz LB, Musher BL, et al. PROSPECT: A randomized phase III trial of neoadjuvant chemoradiation versus neoadjuvant FOLFOX chemotherapy with selective use of chemoradiation, followed by total mesorectal excision (TME) for treatment of locally advanced rectal cancer (LARC) (Alliance N1048). JCO. 2023 Jun 10;41(17_suppl):LBA2–LBA2.SchragDShiQWeiserMRGollubMJSaltzLBMusherBLPROSPECT: A randomized phase III trial of neoadjuvant chemoradiation versus neoadjuvant FOLFOX chemotherapy with selective use of chemoradiation, followed by total mesorectal excision (TME) for treatment of locally advanced rectal cancer (LARC) (Alliance N1048)2023Jun104117_supplLBA2LBA2Search in Google Scholar
Pei-Rong Ding, Neoadjuvant chemotherapy with CAPOX versus chemoradiation for locally advanced rectal cancer with uninvolved mesorectal fascia (CONVERT): Final results of a phase III trial, LBA26, ESMO 2023DingPei-RongESMO2023Search in Google Scholar
ASCO, Cancer.net, https://www.cancer.net/cancer-types/colorectal-cancer/risk-factors-and-preventionASCOhttps://www.cancer.net/cancer-types/colorectal-cancer/risk-factors-and-preventionSearch in Google Scholar
Donnelly M, Ryan OK, Ryan ÉJ, Creavin B, O’Reilly M, McDermott R, et al. Total neoadjuvant therapy versus standard neoadjuvant treatment strategies for the management of locally advanced rectal cancer: network meta-analysis of randomized clinical trials. Br J Surg. 2023 Sep 6;110(10):1316–30.DonnellyMRyanOKRyanÉJCreavinBO’ReillyMMcDermottRTotal neoadjuvant therapy versus standard neoadjuvant treatment strategies for the management of locally advanced rectal cancer: network meta-analysis of randomized clinical trials2023Sep611010131630Search in Google Scholar
Li XT, Zhang XY, Sun YS, Tang L, Cao K. Evaluating rectal tumor staging with magnetic resonance imaging, computed tomography, and endoluminal ultrasound: A meta-analysis. Medicine (Baltimore). 2016 Nov;95(44):e5333.LiXTZhangXYSunYSTangLCaoKEvaluating rectal tumor staging with magnetic resonance imaging, computed tomography, and endoluminal ultrasound: A meta-analysis2016Nov9544e5333Search in Google Scholar
Crimì F, Lacognata C, Cecchin D, Zucchetta P, Pomerri F. Rectal cancer staging: An up-to-date pictorial review. J Med Imaging Radiat Oncol. 2018 Jul 5;CrimìFLacognataCCecchinDZucchettaPPomerriFRectal cancer staging: An up-to-date pictorial review2018Jul5Search in Google Scholar
Fokas E, Smith JJ, Garcia-Aguilar J, Glynne-Jones R, Buyse M, Rödel C, Outcome measures in multimodal rectal cancer trials. Lancet Oncol 2020:e252–e264FokasESmithJJGarcia-AguilarJGlynne-JonesRBuyseMRödelCOutcome measures in multimodal rectal cancer trials2020e252e264Search in Google Scholar
Johnson GGRJ, Park J, Helewa RM, Goldenberg BA, Nashed M, Hyun E. Total neoadjuvant therapy for rectal cancer: a guide for surgeons. Can J Surg. 2023;66(2):E196–201.JohnsonGGRJParkJHelewaRMGoldenbergBANashedMHyunETotal neoadjuvant therapy for rectal cancer: a guide for surgeons2023662E196201Search in Google Scholar
Cercek A, Lumish M, Sinopoli J, Weiss J, Shia J, Lamendola-Essel M, et al. PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer. N Engl J Med. 2022 Jun 23;386(25):2363–76.CercekALumishMSinopoliJWeissJShiaJLamendola-EsselMPD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer2022Jun2338625236376Search in Google Scholar
Zhenyu Lin, Neoadjuvant short-course radiotherapy followed by camrelizumab plus chemotherapy versus long-course chemoradiotherapy followed by chemotherapy in locally advanced rectal cancer: A randomized phase III trial (UNION), LBA25, ESMO 2023.LinZhenyuESMO2023Search in Google Scholar