Assessment of adrenaline-induced DNA damage in whole blood cells with the comet assay

1. Verberne AJM, Korim WS, Sabetghadam A, Llewellyn-Smith IJ. Adrenaline: insights into its metabolic roles in hypoglycaemia and diabetes. Br J Pharmacol 2016;173:1425-37. doi: 10.1111/bph.13458Search in Google Scholar

2. Spalding A, Vaitkevicius H, Dill S, MacKenzie S, Schmaier A, Lockette W. Mechanism of epinephrine-induced platelet aggregation. Hypertension 1998;31:603-7. doi: 10.1161/01.HYP.31.2.6039461228Search in Google Scholar

3. The American Society of Health-System Pharmacists (ASHSP). Epinephrine [displayed 15 August 2015]. Available at https://www.drugs.com/monograph/epinephrine.htmlSearch in Google Scholar

4. Adameova A, Abdellatif Y, Dhalla NS. Role of the excessive amounts of circulating catecholamines and glucocorticoids in stress-induced heart disease. Can J Physiol Pharm 2009;87:493-514. doi: 10.1139/y09-042Search in Google Scholar

5. Drell IV TL, Joseph J, Lang K, Niggemann B, Zaenker KS, Entschladen F. Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells. Breast Cancer Res Tr 2003;80:63-70. doi: 10.1023/A:1024491219366Search in Google Scholar

6. Pu J, Bai D, Yang X, Lu X, Xu L, Lu J. Adrenaline promotes cell proliferation and increases chemoresistance in colon cancer HT29 cells through induction of miR-155. Biochem Bioph Res Co 2012;428:210-5. doi: 10.1016/j.bbrc.2012.09.126Search in Google Scholar

7. Sherwood L, editor. Human Physiology: From Cells to Systems. 7th ed. Belmont (CA): Thomson Brooks/Cole; 2009.Search in Google Scholar

8. Gavrilović Lj, Stojiljković V, Kasapović J, Pejić S, Todorović A, Pajović BS, Dronjak S: Chronic physical stress changes gene expression of catecholamine biosynthetic enzymes in the adrenal medulla of adult rats. Acta Vet-Beograd 2012;62:151-69. doi: 10.2298/AVB1203151GSearch in Google Scholar

9. Dhalla NS, Sasaki H, Mochizuki S, Dhalla KS, Liu X, Elimban V. Catecholamine-induced cardiomyopathy. In: D. Acosta, Jr., editor. Cardiovascular toxicology. 3rd ed. New York (NY): CRC Press; 2001. p. 263-318.Search in Google Scholar

10. Miura T, Muraoka S, Fujimoto Y, Zhao K. DNA damage induced by catechol derivatives. Chem-Biol Interact 2000;126:125-36. doi: 10.1016/S0009-2797(00)00156-3Search in Google Scholar

11. Djelić N, Anderson D. The effect of the antioxidant catalase on oestrogens, triiodothyronine, and noradrenaline in the Comet assay. Teratogen Carcin Mut 2003;23(Suppl 2):69-81. doi: 10.1002/tcm.10084Search in Google Scholar

12. Dobrzyńska MM, Baumgartner A, Anderson D. Antioxidants modulate thyroid hormone and noradrenaline-induced DNA damage in human sperm. Mutagenesis 2004;19:325-30. doi: 10.1093/mutage/geh037Search in Google Scholar

13. Flint MS, Baum A, Chambers WH, Jenkins FJ. Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormones. Psychoneuroendocrinology 2007;32:470-9. doi: 10.1016/j.psyneuen.2007.02.013Search in Google Scholar

14. Čabarkapa A, Živković L, Žukovec D, Djelić N, Bajić V, Dekanski D, Spremo-Potparević B. Protective effect of dry olive leaf extract in adrenaline induced DNA damage evaluated using in vitro comet assay with human peripheral leukocytes. Toxicol in Vitro 2014;28:451-6. doi: 10.1016/j.tiv.2013.12.014Search in Google Scholar

15. Radaković M, Đelić N, Stevanović J, Anđelković M, Kolarević S, Dačić S, Stanimirović Z. The investigation of DNA damage induced by adrenaline in human lymphocytes in vitro. Acta Vet-Beograd 2014;64:281-92. doi: 10.2478/ acve-2014-0027Search in Google Scholar

16. Behonick GS, Novak MJ, Nealley EW, Baskin SI. Toxicology update: the cardiotoxicity of the oxidative stress metabolites of catecholamines (aminochromes). J Appl Toxicol 2001;21(Suppl 1):S15-22. doi: 10.1002/jat.793Search in Google Scholar

17. Genova ML, Abd-Elsalam NM, Mahdy el SME, Bernacchia A, Lucarini M, Pedulli GF, Lenaz G. Redox cycling of adrenaline and adrenochrome catalysed by mitochondrial Complex I. Arch Biochem Biophys 2006;447:167-73. doi: 10.1016/j.abb.2006.01.010Search in Google Scholar

18. Djelić N, Radaković M, Spremo-Potparević B, Živković L, Bajić V, Stevanović J, Stanimirović Z. Evaluation of cytogenetic and DNA damage in human lymphocytes treated with adrenaline in vitro. Toxicol in Vitro 2015;29:27-33. doi: 10.1016/j.tiv.2014.08.001Search in Google Scholar

19. Djelić N, Djelić D, Spremo-Potparević B, Marković B, Živković L. Cytogenetic analysis of the effects of epinephrine on cultured human lymphocytes. Acta Vet-Beograd 2003;53:113-20.10.2298/AVB0303113DSearch in Google Scholar

20. Lankoff A, Carmichael WW, Grasman KA, Yuan M. The uptake kinetics and immunotoxic effects of microcystin-LR in human and chicken peripheral blood lymphocytes in vitro. Toxicology 2004;204:23-40. doi: 10.1016/j.tox.2004.05.016Search in Google Scholar

21. Willcox KJ, Ash SL, Catignani GL. Antioxidants and prevention of chronic disease. Crit Rev Food Sci Nutr 2004;44:275-95. doi: 10.1080/10408690490468489Search in Google Scholar

22. Anderson D, Yu TW, Phillips BJ, Schmezer P. The effect of various antioxidants and other modifying agents on oxygenradical- generated DNA damage in human lymphocytes in the Comet assay. Mutat Res-Fund Mol M 1994;307:261-71. doi: 10.1016/0027-5107(94)90300-XSearch in Google Scholar

23. Cemeli E, Schmid TE, Anderson D. Modulation by flavonoids of DNA damage induced by estrogen-like compounds. Environ Mol Mutagen 2004;44:420-6. doi: 10.1002/em.20071Search in Google Scholar

24. Živković L, Borozan S, Čabarkapa A, Topalović D, Ciptasari U, Bajić V, Spremo-Potparević B. Antigenotoxic properties of Agaricus blazei against hydrogen peroxide in human peripheral blood cells. Oxid Med Cell Longev 2017;2017:8759764. doi: 10.1155/2017/8759764Search in Google Scholar

25. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184-91. doi: 10.1016/0014-4827(88)90265-0Search in Google Scholar

26. Singh NP. Apoptosis assessment by the DNA diffusion assay. In: Blumenthal RD, editors. Chemosensitivity: Volume II. In vivo models, imaging, and molecular regulators. Totowa (NJ): Humana Press Inc.; 2005. p. 55-67.Search in Google Scholar

27. Aherne SA, O’Brien NM. Mechanism of protection by the flavonoids, quercetin and rutin, against tertbutylhydroperoxide- and menadione-induced DNA single strand breaks in Caco-2 cells. Free Radical Bio Med 2000;29:507-14. doi: 10.1016/S0891-5849(00)00360-9Search in Google Scholar

28. Kadrabova J, Krajcovicova-Kudlackova M, Madaric A, Valachovicova M, Mislanova C, Korenovska M. Protective properties of complex of quercetin, selenium, catechins and curcumin against DNA damage. Oxid Antioxid Med Sci 2012;1:179-84. doi: 10.5455/oams.180912.or.018Search in Google Scholar

29. Myhrstad MCW, Carlsen H, Nordström O, Blomhoff R, Moskaug JØ. Flavonoids increase the intracellular glutathione level by transactivation of the γ-glutamylcysteine synthetase catalytical subunit promoter. Free Radical Bio Med 2002;32:386-93. doi: 10.1016/S0891-5849(01)00812-7Search in Google Scholar

30. Wilms LC, Hollman PC, Boots AW, Kleinjans JC. Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes. Mutat Res 2005;582:155-62. doi: 10.1016/j.mrgentox.2005.01.006Search in Google Scholar

31. Cemeli E, Baumgartner A, Anderson D. Antioxidants and the Comet assay. Mutat Res 2009;681:51-67. doi: 10.1016/j.mrrev.2008.05.002Search in Google Scholar

32. Persad S, Takeda S, Panagia V, Dhalla NS. β-adrenoceptorlinked signal transduction in ischemic-reperfused heart and scavenging of oxyradicals. J Mol Cell Cardiol 1997;29:545-58. doi: 10.1006/jmcc.1996.0298Search in Google Scholar

33. Chiaramonte R, Bartolini E, Riso P, Calzavara E, Erba D, Testolin G, Comi P, Sherbet GV. Oxidative stress signalling in the apoptosis of Jurkat T-lymphocytes. J Cell Biochem 2001;82:437-44. doi: 10.1002/jcb.115811500920Search in Google Scholar

34. Benhusein GM, Mutch E, Aburawi S, Williams FM. Genotoxic effect induced by hydrogen peroxide in human hepatoma cells using comet assay. Libyan J Med 2010;5:1-6. doi: 10.3402/ljm.v5i0.4637Search in Google Scholar

35. Imlay JA, Linn S. DNA damage and oxygen radical toxicity. Science 1988;240:1302-9. doi: 10.1126/science.3287616Search in Google Scholar

36. Đelić N. Mechanisms of genotoxic effects of hormones. Genetika 2002;34:59-71.10.2298/GENSR0203059DSearch in Google Scholar

37. Collins A, Ai-guo M, Duthie S. The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells. Mutat Res 1995;336:69-77. doi: 10.1016/0921-8777(94)00043-6Search in Google Scholar

38. Parshad R, Price FM, Bohr VA, Cowans KH, Zujewski JA, Sanford KK. Deficient DNA repair capacity, a predisposing factor in breast cancer. Brit J Cancer 1996;74:1-5. PMCID: PMC207460810.1038/bjc.1996.30720746088679441Search in Google Scholar

39. Forlenza MJ, Latimer JJ, Baum A. The effects of stress on DNA repair capacity. Psychol Health 2000;15:881-91. doi: 10.1080/08870440008405589.Search in Google Scholar