<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Objectives:</bold> Several studies have questioned the need for platelet function testing in patients treated with new ADP receptor blockers (ADPRB). The aim of this study was to evaluate the prevalence of high on-treatment platelet reactivity (HTPR) among acute ST-elevation myocardial infarction (STEMI) patients treated with newer ADPRB.<bold>Methods:</bold> A prospective study enrolling 44 acute previously ADPRB naive STEMI patients (31 men, 13 women) undergoing primary percutaneous coronary intervention (pPCI) was performed. Among the studied population 23 patients received prasugrel and 21 patients received ticagrelor. Antiplatelet response was tested with light transmission aggregometry (LTA) and vasodilator-stimulated phosphoprotein phosphorylation (VASP-P) flow cytometry assay. Samples were taken prior to coronary angiography (sample 1) and on the day after this procedure (sample 2).<bold>Results:</bold> The mean platelet aggregation after induction with ADP was 51.7 ± 24.8% in sample 1 and 25.3 ± 20.1% in sample 2. An examination of VASP-P showed a mean platelet reactivity index of 56.8 ± 25.7% in sample 1 and 23.8 ± 23.1% in sample 2, respectively. The study identified 11.4% of patients in sample 2 as ADP receptor blocker non-responders. No significant differences were found between prasugrel-treated to ticagrelor-treated patients.<bold>Conclusions:</bold> This pilot study demonstrated HTPR among acute STEMI patients treated with newer ADPRB.</abstract>

Objectives: Several studies have questioned the need for platelet function testing in patients treated with new ADP receptor blockers (ADPRB). The aim of this study was to evaluate the prevalence of high on-treatment platelet reactivity (HTPR) among acute ST-elevation myocardial infarction (STEMI) patients treated with newer ADPRB.Methods: A prospective study enrolling 44 acute previously ADPRB naive STEMI patients (31 men, 13 women) undergoing primary percutaneous coronary intervention (pPCI) was performed. Among the studied population 23 patients received prasugrel and 21 patients received ticagrelor. Antiplatelet response was tested with light transmission aggregometry (LTA) and vasodilator-stimulated phosphoprotein phosphorylation (VASP-P) flow cytometry assay. Samples were taken prior to coronary angiography (sample 1) and on the day after this procedure (sample 2).Results: The mean platelet aggregation after induction with ADP was 51.7 ± 24.8% in sample 1 and 25.3 ± 20.1% in sample 2. An examination of VASP-P showed a mean platelet reactivity index of 56.8 ± 25.7% in sample 1 and 23.8 ± 23.1% in sample 2, respectively. The study identified 11.4% of patients in sample 2 as ADP receptor blocker non-responders. No significant differences were found between prasugrel-treated to ticagrelor-treated patients.Conclusions: This pilot study demonstrated HTPR among acute STEMI patients treated with newer ADPRB.

On-treatment platelet reactivity in the era of new ADP receptor blockers: data from a real-world clinical practice

National Centre of Hemostasis and Thrombosis, Department of Hematology and Blood Transfusion, Jessenius Faculty of Medicine in Martin

Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin

Acta Medica Martiniana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Objectives: Several studies have questioned the need for platelet function testing in patients treated with new ADP receptor blockers (ADPRB). The aim of this...

On-treatment platelet reactivity in the era of new ADP receptor blockers: data from a real-world clinical practice

Published Online: Dec 07, 2018

Page range: 34 - 39

Received: Sep 05, 2018

Accepted: Sep 30, 2018

DOI: https://doi.org/10.2478/acm-2018-0011

Keywords
High on-treatment platelet reactivity, tailored antiplatelet therapy, prasugrel, ticagrelor, acute myocardial infarction

© 2018 Skornova I et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

On-treatment platelet reactivity in the era of new ADP receptor blockers: data from a real-world clinical practice

Published Online: Dec 07, 2018

Page range: 34 - 39

Received: Sep 05, 2018

Accepted: Sep 30, 2018

DOI: https://doi.org/10.2478/acm-2018-0011

KeywordsHigh on-treatment platelet reactivity, tailored antiplatelet therapy, prasugrel, ticagrelor, acute myocardial infarction

© 2018 Skornova I et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
High on-treatment platelet reactivity, tailored antiplatelet therapy, prasugrel, ticagrelor, acute myocardial infarction