<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The aim of this study was to assess whether atipamezole can restrain telazol/xylazine induced expression of c-fos in the rat brain. Rats were injected with a mixture of 13.81 mg/kg telazol and 5.21 mg/kg xylazine, following 10 min later 0.522 mg/kg atipamezole. Thereon, the thalamencephal and cerebral cortex were removed one hour after the last injection. The level of Fos protein was measured in the brain tissue by Westernblot. The results revealed that atipamezole attenuates telazol/xylazine induction of c-fos expression in the thalamencephal and cerebral cortex. The results indicated that atipamezole is able to inhibit telazol/xylazine-induced c-fos expression in the rat brain, thus protecting it from nerve damage.</p></abstract>

The aim of this study was to assess whether atipamezole can restrain telazol/xylazine induced expression of c-fos in the rat brain. Rats were injected with a mixture of 13.81 mg/kg telazol and 5.21 mg/kg xylazine, following 10 min later 0.522 mg/kg atipamezole. Thereon, the thalamencephal and cerebral cortex were removed one hour after the last injection. The level of Fos protein was measured in the brain tissue by Westernblot. The results revealed that atipamezole attenuates telazol/xylazine induction of c-fos expression in the thalamencephal and cerebral cortex. The results indicated that atipamezole is able to inhibit telazol/xylazine-induced c-fos expression in the rat brain, thus protecting it from nerve damage.

Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex

Department of Veterinary Science, Jilin Agriculture Science and Technology College, Jilin 132101, China

Key Lab of Preventive Veterinary Medicine in Jilin Province, Jilin 132101,

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030,

Department of Veterinary Science, Jilin Agriculture Science and Technology College, Jilin 132101,

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The aim of this study was to assess whether atipamezole can restrain telazol/xylazine induced expression of c-fos in the rat brain. Rats were injected with a...

Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex

Published Online: Dec 30, 2016

Page range: 489 - 496

Received: Jun 02, 2016

Accepted: Sep 22, 2016

DOI: https://doi.org/10.1515/acve-2016-0042

Keywords
atipamezole, telazol, xylazine, rat, c-fos, brain

© by Wang Hong-Bin

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex

Published Online: Dec 30, 2016

Page range: 489 - 496

Received: Jun 02, 2016

Accepted: Sep 22, 2016

DOI: https://doi.org/10.1515/acve-2016-0042

Keywordsatipamezole, telazol, xylazine, rat, c-fos, brain

© by Wang Hong-Bin

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
atipamezole, telazol, xylazine, rat, c-fos, brain