This clinical study included a total of 71 patients with chronic generalized periodontitis (CGP). The chemiluminescence method was used to determine the level of generation of reactive oxygen species by leukocytes (basal and stimulated), as well as the content of malonic dialdehyde in blood plasma and antiperoxide activity of plasma. The anxiety level was measured using the Spielberger’s test. Patients with chronic generalized periodontitis in the exacerbation phase were found to have a natural significant increase in both basal and stimulated PICL, as well as an increase in blood plasma malonic dialdehyde 1.6-, 3.9- and 1.4-fold, respectively, compared with apparently healthy donors (all p<0.05), and a significant 2.1-fold decrease in plasma APA compared with healthy donors (p<0.001). In the remission phase, all parameters were normalized, however, they did not reach the norm. We revealed significant dependence of reactive oxygen species generation by leukocytes, lipid peroxidation and antiperoxide activity of plasma on the severity of the course of chronic generalized periodontitis, whereas plasma antiperoxide activity decreased. In patients with the severe course, after the treatment with AO, situational and personal anxiety increased, depression deteriorated, unlike patients with mild-to-moderate course in whom this symptomatology virtually disappeared. In patients with the severe course of periodontitis after surgical manipulations, the parameter in the Hounsfield units increased gradually, on days 14, 30 and 90 on average, 1.3, 2.4 and 3.2-fold, respectively, thus suggesting that bone tissue density increased faster after surgical methods of treatment in patients with severe chronic generalized periodontitis.
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