Synthesis and Characterization of Zinc(II)-Complexes with S-Alkyl Derivatives of Thiosalicylic Acid

Milos V. Nikolic 1 , Marina Z. Mijajlovic 1 , Dusan Lj. Tomovic 1 , Andriana M. Bukonjic 1 , Verica V. Jevtic 2 , Zoran R. Ratkovic 2 , Srecko R. Trifunovic 2 , and Gordana P. Radic 1
  • 1 University of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Serbia
  • 2 University of Kragujevac, Faculty of Science, Department of Chemistry, Serbia

Abstract

New zinc(II)-complexes with S-alkyl derivatives of thiosalicylic acid (alkyl = benzyl-(L1), methyl-(L2), ethyl-(L3), propyl-(L4), butyl-(L5)) have been synthesized and characterized by elemental microanalysis, IR spectroscopy, and 1H and 13C NMR spectroscopy. The S-alkyl derivatives of thiosalicylic acid were prepared by alkylation of thiosalicylic acid by adding alkyl halides to an alkaline water-ethanol solution, while the corresponding zinc(II)-complexes were obtained via the direct reaction of ZnCl2 with S-alkyl derivatives of thiosalicylic acid in water. Based on the microanalysis results and the IR and NMR spectra of the S-alkyl derivatives of thiosalicylic acid and the corresponding zinc(II)-complexes, we concluded that the ligands are bidentately coordinated to the zinc(II)-ion.

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