Synthesis and Characterization of Platinum (IV) complexes with S-alkyl Derivatives of Thiosalicylic Acid and the Crystal Structure of the S-butyl Derivative of Thiosalicylic Acid

Marina Z. Mijajlovic 1 , Milos V. Nikolic 1 , Dusan Lj. Tomovic 1 , Andriana M. Bukonjic 1 , Aleksandar Kocovic 1 , Verica V. Jevtic 2 , Zoran R. Ratkovic 2 , Olivera Klisuric 3 , Srecko R. Trifunovic 2 , and Gordana P. Radic 1
  • 1 University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Pharmacy, , Kragujevac, Serbia
  • 2 University of Kragujevac, Serbia, Faculty of Science, Department of Chemistry, , Kragujevac, Serbia
  • 3 Department of Physics, University of Novi Sad, Trg Dositeja Obradovica 4, 21000 , Novi Sad, Serbia

Abstract

New platinum(IV)-complexes with S-alkyl derivatives of thiosalicylic acid (alkyl = benzyl-(L1), methyl-(L2), ethyl-(L3), propyl-(L4), butyl-(L5)) have been synthesized and characterized by microanalysis, infrared spectroscopy, and 1H and 13C NMR spectroscopy. Th e bidentate S,O ligand precursor, the S-butyl derivative of thiosalicylic acid (S-bu-thiosal), was prepared, and its crystal structure was determined. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a DMSO-water system. S-bu-thiosal crystallized in a P21/c space group of a monoclinic crystal system with a = 8.0732 (3) Å, b = 19.6769 (4) Å, c = 8.2291 (3) Å and Z = 4. S-bu-thiosal also has a coplanar geometry.

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