Synthesis, Characterization, and Cytotoxicity of Binuclear Cooper(II)-Complexes with some S-Alkenyl Derivatives of Thiosalicyclic Acid

Dusan Lj. Tomovic 1 , Andriana M. Bukonjic 1 , Aleksandar Kocovic 1 , Milos V. Nikolic 1 , Marina Z. Mijajlovic 1 , Verica V. Jevtic 2 , Zoran R. Ratkovic 2 , Aleksandar N. Arsenijevic 1 , Jelena Z. Milovanovic 1 , Bojana Stojanovic 1 , Srecko R. Trifunovic 2 , and Gordana P. Radic 1
  • 1 Faculty of Medical Sciences, University of Kragujevac, Serbia
  • 2 Department of Chemistry, Faculty of Science, University of Kragujevac, Serbia

Abstract

New complexes of copper(II) with S-alkenyl derivatives of thiosalicylic acid (alkenyl = propenyl-(L1), isobutenyl-(L2)) have been synthesized and characterized by microanalysis, infrared spectra, magnetic measurements, and by NMR spectra. The cytotoxic activity of two newly synthesized precursor S-alkenyl derivatives of thiosalicylic acid were tested using an MTT colorimetric technique on HCT-116 human colon carcinoma cells. The cytotoxic effect of the copper(II)- complexes were higher compared to the cytotoxicity of the corresponding ligand (for concentrations from 31.25 to 250 μM). Copper(II)-complexes showed a slightly lower cytotoxicity compared to cisplatin. Complexes of copper(II) with S-alkenyl derivatives of thiosalicylic acid (at concentrations from 250 to 1000 μM) had a cytotoxic effect on HCT-116 cells compared to cisplatin.

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