The Evolving Pattern Of Primary Skin Cancers in Ile-Ife, Nigeria

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Abstract

Background. The increasing solar intensity and HIV epidemic have progressively eroded the protective effects of melanin among black race. This study was aimed at evaluating the pattern of primary skin cancers in Ile-Ife, Nigeria.

Methods. This retrospective study, which was conducted at the Obafemi Awolowo University Teaching Hospital, Ile-Ife, included the patients diagnosed with primary skin cancers between January 2008 and December 2017. The data were analyzed using SPSS version20.

Results. The frequency of primary skin cancers was 1.0%. Females (58.3%) outnumbered the males (41.7%), the ratio being 1.4:1. The spectrum of primary skin cancers documented by this study are squamous cell carcinoma (33.3%), malignant melanoma (25%), Kaposi sarcoma (15.3%), basal cell carcinoma (9.7%), and cutaneous lymphoma (6.9%).

Conclusion. Melanin remains a major protective factor for skin cancers among negroids. Albinism and high burden of HIV were identified risk groups for skin cancers. The eradication of HIV and enhanced sun protection will reduce the prevalence of skin cancers.

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  • 1. Alaluf S Atkins D Barrett K Blount M Carter N Heath A. Ethnic variation in melanin content and composition in photoexposed and photoprotected human skin. Pigment Cell Res. 2002;15(2):112-8.

  • 2. Vitasa BC Taylor HR Strickland PT Rosenthal FS West S Abbey H et al. Association of nonmelanoma skin cancer and actinic keratosis with cumulative solar ultraviolet exposure in Maryland watermen. Cancer. 1990;65(12):2811-7.

  • 3. Zanetti R Rosso S Martinez C Nieto A Miranda A Mercier M et al. Comparison of risk patterns in carcinoma and melanoma of the skin in men: a multi-centre case-case-control study. Br J Cancer. 2006;94(5):743-51.

  • 4. Andrady AL Aueamp PJ Austin A Bais AF Ballaré CL Björn LO et al. Environmental effects of ozone depletion and its interactions with climate change: 2010 assessment. Executive summary. Photochem Photobiol Sci. 2011;10(2):178-81.

  • 5. Bharath AK Turner RJ. Impact of climate change on skin cancer. J R Soc Med. 2009;102(6):215-8.

  • 6. Forae GD Olu-Eddo AN. Malignant skin tumors in Benin City South-South Nigeria. Oman Med J. 2013;28(5):311-5.

  • 7. Oseni GO Olaitan PB Komolafe AO Olaofe OO Hezekiah Akinyemi HA Suleiman OA. Malignant skin lesions in Oshogbo Nigeria. Pan Afr Med J. 2015;20:253.

  • 8. Johnson TM Rowe DE Nelson BR Swanson NA. Squamous cell carcinoma of the skin (excluding lip and oral mucosa). J Am Acad Dermatol. 1992;26(3 Pt 2):467-84.

  • 9. Ziegler A Jonason AS Leffell DJ Simon JA Sharma HW Kimmelman J et al. Sunburn and p53 in the onset of skin cancer. Nature. 1994;372(6508):773-6.

  • 10. D’Orazio J Jarrett S Amaro-Ortiz A Scott T. UV radiation and the skin. Int J Mol Sci. 2013;14(6):12222-48.

  • 11. Christenson LJ Borrowman TA Vachon CM Tollefson MM Otley CC Weaver AL et al. Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years. JAMA. 2005;294(6):681-90.

  • 12. Robinson SN Zens MS Perry AE Spencer SK Duell EJ Karagas MR. Photosensitizing agents and the risk of non-melanoma skin cancer: a population-based case-control study. J Invest Dermatol. 2013;133(8):1950-5.

  • 13 Armstrong BK Kricker A. The epidemiology of UV induced skin cancer. J Photochem Photobiol B. 2001;63 (1-3):8-18.

  • 14. Koh D Wang H Lee J Chia KS Lee HP Goh CL. Basal cell carcinoma squamous cell carcinoma and melanoma of the skin: analysis of the Singapore Cancer Registry data 1968-97. Br J Dermatol. 2003;148(6):1161-6.

  • 15. Kraemer KH Lee MM Andrews AD Lambert WC. The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm. Arch Dermatol. 1994;130(8):1018-21.

  • 16. Grønskov K Ek J Brondum-Nielsen K. Oculocutaneous albinism. Orphanet J Rare Dis. 2007;2:43.

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