Analysis of Pharmaceutical Excipient MCC Avicel PH102 Using Compaction Equations

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This paper focuses on the characterization of the tabletting process and analysis one of the most common pharmaceutical excipients MCC Avicel PH102 by Heckel, Kawakita, Cooper-Eaton and Adams compaction equations. Experimental material was determined by measuring its parameters as particle size distribution, angle of wall friction and flow properties and for more detailed characteristics of the material particles, microscopy images of the powder before and after compressing were created.

[1] ADAMS, M.J., MCKEOWN, R.: Micromechanical analysis of the pressure-volume relationships for powders under confined uniaxial compression. Powder Technology, 88, 1996, pp. 155-163

[2] ANTIKAINEN, O., YLIRUUSI, J.: Determining the compression behavior of pharmaceutical powders from the force-distance compression profile. International Journal of Pharmacology, 252, 2003, pp. 253-261

[3] AUGSBUTGER, L. L., HOAG, S.W.: Pharmaceutical Dosage Forms: Tablets. New York: Informa Healtcare USA, 2008

[4] CELIK, M.: The Past, Present, and Future of Tabletting Technology. Drug Development and Industrial Pharmacy, 22, 1996, pp. 1-10

[5] CHOWHAN, Z.T., CHOW, Y.P.: Compression behavior of pharmaceutical powders. Journal of Pharmaceutical Sciences, 5, 1980, pp. 139-148

[6] CUNNINGHAM, J.C., SINKA, I.C., ZAVALIANGOS, A.: Analysis of Tablet Compaction. I. Characterization of Mechanical Behavior of Powder and Powder/Tooling Friction. Pharmaceutical Technology, 93, 2004, pp. 2022-2039

[7] DECROSTA, M.T., SCHWARTZ, J.B., WIGENT, R.J., MARSHALL, K.: Thermodynamic analysis of compact formation; compaction, unloading, and ejection I. Desing and development of a compaction calorimeter and mechanical and thermal energy determinations of powder compaction. International Journal of Pharmaceutics, 198, 2000, pp. 113-134

[8] DECROSTA, M.T., SCHWARTZ, J.B., WIGENT, R.J., MARSHALL, K.: Thermodynamic analysis of compact formation; compaction, unloading, and ejection II. Mechanical energy (work) and thermal energy (heat) determinations of compact unloading and ejection. International Journal of Pharmaceutics, 213, 2001, pp. 45-62

[9] DENNY, P.J.: Compaction equations: A comparison of the Heckel and Kawakita equations. Powder Technology, 127, 2002, pp. 162-172

[10] ECKERT, M., PECIAR, P., KROK, A., FEKETE, R.: Application of Compaction Equations for Powdered Pharmaceutical Materials. Scientific Proceedings Faculty of Mechanical Engineering, 23, 2016, pp. 6-11

[11] FREEMAN, R.: Measuring the flow properties of consolidated, conditioned and aerated powders - A comparative study using a powder rheometer and a rotational shear cell. Powder Technology, 174, 2007, pp. 25-33

[12] GABAUDE, C., GUILLOT, M., GAUTIER, J.C.: Effects of true density, compacted mass, compression speed, and punch deformation on the mean yield pressure. Journal of Pharmaceutical Sciences, 88, 1999, pp. 725-730

[13] HAN, L.H., ELLIOT, J.A., BENTHAM, A.C., MILLS, A. AMIDON, G.E.: A modified Drucker-Prager Cap model for die compaction simulation of pharmaceutical powders. International Journal of Solid and Structures, 45, 2008, pp. 3088-3106

[14] KAWAKITA, K.: Some considerations on powder compression equations. Powder Technology, 4, 1971, pp. 61

[15] KIEKENS, F., DEBUNNE, A., VERVAET, C.: Influence of the punch diameter and curvature on the yield pressure of MCC-compacts during Heckel analysis. European Journal of Pharmacology, 22, 2004, pp. 117-126

[16] KLINZING, G.R., ZAVALIANGOS, A., CUNNINGHAM, J., MASCARO, T.: Temperature and density evolution during compaction of a capsule shaped tablet. Computers and Chemical Engineering, 34, 2010, pp. 1082-1091

[17] KROK, A., PECIAR, M. FEKETE, R.: Numerical investigation into the influence of the punch shape on the mechanical behavior of pharmaceutical powders during compaction. Particuology, 16, 2013, pp. 116-131

[18] MAHMOODI, F.: Compression Mechanics of Powders and Granular Materials Probed by Force Distributions and a Micromechanically Based Compaction Equation. Uppsala: Acta Universitatis Upsaliensis, 2012

[19] NICKLASSON, F., ALBETBORN, G.: Analysis of the compression mechanics of pharmaceutical agglomerates of different porosity and composition using the Adams and Kawakita equations. Pharmaceutical Research, 17, 2009, pp. 49-954

[20] ROUÉCHE, E., SERRIS, E., THOMAS, G., CAMBY, L.: Influence of temperature on compaction of an organic powder and the mechanical strength of tablets. Powder Technology, 162, 2006, pp. 138-144

[21] SHANG, C., SINKA, I.C., PAN, J.: Constitutive Model Calibration for Powder Compaction Using Instrumented Die Testing. Society for Experimental Mechanics, 98, 2011, pp. 69-75

[22] SHI, L., CHATTORAJ, S., SUN, C.C.: Reproducibility of flow properties of microcrystalline cellulose - Avicel PH102. Powder Technology, 212, 2011, pp. 253-257

[23] SONNERGAARD, J.M.: A critical evaluation of the Heckel equation. International Journal of Pharmacology, 193, 1999, pp. 63-71

[24] SONNERGAARD, J.M.: Impact of particle density and initial volume on mathematical compression models. European Journal of Pharmaceutical Sciences, 11, 2000, pp. 307-315

[25] SØGAARD, S., BRYDER, M., ALLESØ, M., RANTANEN, J.: Characterization of powder properties using a powder rheometer. Proceedings of Electronic Conference on Pharmaceutical Sciences, 2, 2012

[26] Tablets (compressi). European Pharmacopoeia, Directorate for the Quality of Medicines and Health Care of the Council of Europe, 1, 2008

[27] WASHINGTON, C.: Particle size analysis in pharmaceutics and other industries. CRC Press, 1992

[28] WIACEK, J., MOLENDA, M.: Effect of particle size distribution on micro- and macromechanical response of granular packings under compression. International Journal of Solids and Structures, 51, 2014, pp. 4189-4195

[29] WU, C.Y., RUDDY, O.M., BENTHAM, A.C., HANCOOK, B.C., BEST, S.M.: Modelling the mechanical behavior of pharmaceutical powders during compaction. Powder Technology, 152, 2005, pp. 107-117

[30] YORK, P., PILPEL, N.: The effect of temperature on the mechanical properties of some pharmaceutical powders in relation to tabletting. Journal of Pharmacy and Pharmacology, 24, 1972, pp. 47-56

[31] ZAVALIANGOS, A., GALEN, S., CUNNINGHAM, J.: Temperature Evolution during Compaction of Pharmaceutical Powders. Pharmaceutical Technology, 97, 2008, pp. 3291-3304

[32] GOGA V., HUČKO B.: Phenomenological Material Model of Foam Solids. In Journal of Mechanical Engineering - Strojnícky časopis, Vol. 65, No. 1, 2015, pp. 5-20, ISSN 0039-2472

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