The experiment was conducted on 18 Wistar rats during a six-week period; 12 animals were given zinc lactate (120 mg/rat and week) in feed mixture and 6 control animals were fed a standard mixture for rats (ST-1). Sixteen biochemical parameters were measured from blood (serum) samples: total protein (TP), albumin (ALB), urea (UREA), glucose (GLU), triacylglycerols (TAG), non-esterified fatty acids (NEFA), cholesterol (CHOL), creatinine (CREAT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), uric acid (UA), magnesium (Mg), calcium (Ca), phosphorus (P), and trace elements such as Fe and Zn. When compared to the control group, we found that rats fed zinc lactate had higher concentrations of GLU, UA, UREA, Fe, Mg, Ca, TAG, TP, ALB, and ALP in the blood serum. Contrarily, the concentrations of AST, NEFA, CHOL, CREAT, P, and Zn were higher in the blood serum of control rats. Statistically significant differences between rats fed Zn and the control were found only in the concentrations of GLU, AST, ALP, UA, and P.
If the inline PDF is not rendering correctly, you can download the PDF file here.
Allen LH (1998): Zinc and micronutrient supplements for children. American Journal of Clinical Nutrition 68 495–498.
Awe EO Banjoko SO (2013): Biochemical and haematological assessment of toxic effects of the leaf ethanol extract of Petroselinum crispum (Mill) Nyman ex AW Hill (Parsley) in rats. BMC Complementary and Alternative Medicine 13 75. doi: 10.1186/1472-6882-13-75.
Baltaci AK Ozyurek K Mogulkoc R Kurtoglu E Ozkan Y Celik I (2003): Effects of zinc deficiency and supplementation on the glycogen contents of liver and plasma lactate and leptin levels of rats performing acute exercise. Biological Trace Element Research 96 227–236. doi: 10.1385/BTER:96:1-3:227.
Berchová-Bímová K Soltysiak J Vach M (2014): Role of different taxa and cytotypes in heavy metals absorption in knotweeds (Fallopia). Scientia Agriculturae Bohemica 45 11–18. doi: 10.7160/sab.2014.450102.
Bonakdaran S Khajeh-Dalouie M Jalili-Shahri J (2009): Correlation between serum zinc level with impaired glucose tolerance and insulin resistance in major thalassemic patients. Iranian Journal of Endocrinology and Metabolism 11 667–672.
Dehshal MH Hooghooghi AH Kebryaeezadeh A Kheirabadi M Kazemi S Nasseh A Shariftabrizi A Pasalar P (2007): Zinc deficiency aggravates abnormal glucose metabolism in thalassemia major patients. Medical Science Monitor 13 235–239.
Dvořáková M Weingartová I Nevoral J Němeček D Krejčová T (2015): Garlic sulfur compounds suppress cancerogenesis and oxidative stress: a review. Scientia Agriculturae Bohemica 46 65–72. doi: 10.1515/sab-2015-0018.
Fosmire GJ (1990): Zinc toxicity. American Journal of Clinical Nutrition 51 225–227.
Garban G Silaghi-Dumitrescu R Ionita H Garban Z Hadaruga NG Ghibu GD Balta C Simiz FD Mitar C (2013): Influence of novel Gallium complexes on the homeostasis of some biochemical and hematological parameters in rats. Biological Trace Element Research 155 387–395.
Hambidge K Krebs NF (2007): Zinc deficiency: a special challenge. Journal of Nutrition 137 1101–1105.
Iciek M Inga Kwiecień I Włodek L (2009): Biological properties of garlic and garlic-derived organosulfur compounds. Environmental and Molecular Mutagenesis 50 247–265. doi: 10.1002/em.20474.
Johnson-Delaney C (1996): Exotic companion medicine handbook for veterinarians. Zoological Education Network Lake Worth.
Kaslow JE (2014): Alkaline phosphatase. http://www.drkaslow.com/html/alkaline_phosphatase.html. Accessed 01.04.2014
King JC Shames DM Woodhouse LR (2000): Zinc homeostasis in humans. The Journal of Nutrition 130 1360–1366.
Maret W Sandstead HH (2006): Zinc requirements and the risks and benefits of zinc supplementation. Journal of Trace Elements in Medicine and Biology 20 3–18. doi: 10.1016/j.jtemb.2006.01.006.
Mizari N Hirbod-Mobarakeh A Shahinpour S Ghalichi-Tabriz M Beigy M Yamini A Reza Dehpour A (2012): Effect of subchronic zinc toxicity on rat salivary glands and serum composition. Toxicology and Industrial Health 28 917–922. doi: 10.1177/0748233711427052.
Nelson DL Cox MM (2005): Lehninger principles of biochemistry. W.H. Freeman and Company New York.
Plum LM Rink L Haase H (2010): The essential toxin: impact of zinc on human health. International Journal of Environmental Research and Public Health 7 1342–1365. doi:10.3390/ijerph7041342.
Prasad AS Brewer GJ Schoomaker EB Rabbani P (1978): Hypocupremia induced by zinc therapy in adults. JAMA 240 2166–2168.
Rink L Gabriel P (2000): Zinc and immune system. Proceedings of the Nutrition Society 59 541–552. doi: 10.1017/S0029665100000781.
Suliburska J Bogdanski P Jakubowski H (2014): The influence of selected antihypertensive drugs on zinc copper and iron status in spontaneously hypersensitive rats. European Journal of Pharmacology 738 326–331. doi: 10.1016/j.ejphar.2014.06.003.
Tao L Zheng Y Shen Z Li Y Tian X Dou X Qian J Shen H (2013): Psychological stress-induced lower serum zinc and zinc redistribution in rats. Biological Trace Element Research 155 65–71. doi: 10.1007/s12011-013-9762-0.
Uyanik F Eren M Tuncoku G (2001): Effects of supplemental zinc on growth serum glucose cholesterol enzymes and minerals in broilers. Pakistan Journal of Biological Sciences 4 745–747. doi: 10.3923/pjbs.2001.745.747.
Weingartová I Dvořáková M Nevoral J Vyskočilová A Sedmíková M Rylková K Kalous L Jílek F (2015): Back in time: fish oocyte as a superior model for human reproduction? A review. Scientia Agriculturae Bohemica 46 7–20. doi: 10.1515/sab-2015-0011.
Whitney EN Rolfes SR (2013): Understanding Nutrition. 13th Ed. Wadsworth Cengage Learning. Australia Belmont CA. WHO (1996): Trace elements in human nutrition and health. World Health Organization Geneva:
Yang H Keen CL Lanoue L (2015): Influence of intracellular zinc on cultures of rat cardiac neural crest cells. Developmental and Reproductive Toxicology 104 11–22. doi: 10.1002/bdrb.21135.
Yang Y Jing XP Zhang SP Gu RX Tang FX Wang XL Xiong MQ Sun XY Ke D Wang JZ Liu R (2013): High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signalling. PLoS ONE 8 e55384. doi: 10.1371/journal.pone.0055384.
Zhang ZP Tian YH Li R Cheng XQ Guo SM Zhang JX Wang JJ Hu L (2004): The comparison of the normal blood biochemical values of Wistar rats with different age and sex. Asian Journal of Drug Metabolism and Pharmacokinetics 4 215–218.