Can we find accessible and relevant markers for sepsis outcome?

Andreea Paula Cioară 1 , Mirela Flonta 2 , Astrid Binder 2 , Andreea Pop 2 , Violeta Siladi 2 , Nicolae Todor 3 , Victor Cristea 1 ,  and Mihaela Lupse 1
  • 1 University of Medicine and Pharmacy „Iuliu Hațieganu”, Cluj-Napoca, Romania
  • 2 Teaching Hospital of Infectious Diseases, Cluj-Napoca, Romania
  • 3 ”Prof. Dr. Ion Chiricuța” Institute of Oncology, Cluj-Napoca, Romania


Background and Aim: Sepsis is a life-threatening disease with high mortality, therefore establishing early diagnostic and finding reliable prognostic biomarkers is vital. We aimed to investigate the prognostic role, as a single value, of serum procalcitonin, C-reactive protein, serum lactate, platelets number and serum glucose level in septic patients, all measured in the first 24 hours after hospital admittance.

Materials and methods: This retrospective study included 241 adult patients with sepsis, severe sepsis or septic shock. We use data from patients observation sheets. Data that were collected include: demographic parameters, comorbidities, necessity of mechanical ventilation and laboratory variables. We performed the statistical analysis with the chi square test for nonparametric data and to analyse the accuracy of prediction we used the receiver - operator curves with the level of significance set at p < 0.05.

Results: From 241 patients with a median age of 68 years, 127 (52.69%) were male.113 patients had severe sepsis. 89 patients (36.9%) died and male had an increase mortality rate. Most cases were respiratory sepsis (45.20%). The highest mortality rate was in septic shock (51.2%). Procalcitonin, C-reactive protein and glucose serum level at admittance were not correlated with mortality. The serum levels of creatinine >1.67 mg/dL and serum lactate >1.9 mmol/L at admittance were correlated with mortality (p < 0.01). The cutoff value of 121×103/uL platelets number was also correlated with mortality (p < 0.01).

Conclusions: Our findings suggest that serum creatinine, serum lactate and the platelets number could be used as prognostic markers in septic patients at admittance.

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