IL-6 gene polymorphisms and sepsis in icu adult romanian patients: a prospective study

Anca Meda Georgescu 1 , Claudia Bănescu 2 , Iudita Badea 3 , Valeriu Moldovan 4 , Adina Huțanu 5 , Septimiu Voidăzan 6 , Minodora Dobreanu 5 ,  and Leonard Azamfirei 3
  • 1 Infectious Diseases Clinic, University of Medicine and Pharmacy Tirgu Mureș, Romania
  • 2 Department of Genetics, University of Medicine and Pharmacy, Tirgu Mureș, Romania
  • 3 Anesthesiology and Intensive Care Clinic, University of Medicine and Pharmacy Tîrgu Mureș, Romania
  • 4 Genetics Laboratory, Center for Advanced Medical and Pharmaceutical Research, University of Medicine and Pharmacy Tîrgu Mureș, Romania
  • 5 Immunology Laboratory, Center for Advanced Medical and Pharmaceutical Research, University of Medicine and Pharmacy Tîrgu Mureș, Romania
  • 6 Department of Epidemiology, University of Medicine and Pharmacy Tîrgu Mureș, Romania


Objectives: The goal of the study was to investigate the correlations between the interleukin-6 IL-6 -174 G/C and IL-6 -572 G/C gene polymorphisms and sepsis risk and severity in adult ICU patients.

Materials and Methods: We prospectively assessed 107 septic patients and divided them into two subgroups: organ dysfunction-free sepsis subgroup S (n=60) and septic shock subgroup SS (n=47). A control group of 96 healthy individuals was included. Both patients and controls underwent IL-6 -174 G/C and -572 G/C genotyping and circulating IL-6 in the study group which were measured from samples taken in the first day of sepsis diagnosis.

Results: No differences in the genotype frequencies of the two polymorphisms between study and control groups were identified. The GC genotype and C allele of IL-6 -572 G/C gene polymorphism was statistically significant more frequent in the organ dysfunction-free subgroup (p=0.01, p=0.004 respectively). No statistically significant differences for the IL-6 -174 G/C gene polymorphism were found between the two sepsis subgroups. Circulating IL-6 levels were significantly higher in the septic shock subgroup and among patients with GG genotypes of both studied polymorphisms.

Conclusion: We underline the possible role of IL-6 -572 G/C as a marker of severe evolution. There is no evidence of a direct role of IL-6 -174 G/C gene polymorphism in sepsis risk and outcome. Il-6 levels are correlated with sepsis severity but not with variant genotype of investigated IL-6 gene polymorphisms.

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