Association of “cup-like” blasts morphology with NPM1 mutation in acute myeloid leukemia

Nicoleta Berbec 1 , Anca Roxana Lupu 2 , Silvana Angelescu 2 , Diana Mandescu 2 , und Maria Bari 3
  • 1 Coltea Clinical Hospital
  • 2 Coltea Clinical Hospital / Carol Davila University of Medicine and Pharmacy
  • 3 Carol Davila University of Medicine and Pharmacy

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  • 2. Falini B, Mecucci C, Tiacci E, Alcalav M, Rosati R, Pasqualucci L et al.; GIMEMA Acute Leukemia Working Party. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype [published correction appears in N Engl J Med. 2005;352:740]. N Engl J Med. 2005 Jan;352(3):254-66. DOI: 10.1056/ NEJMoa041974

  • 3. Kroschinsky FP, Schäkel U, Fischer R, Mohr B, Oelschlaegel U, Repp R et al., for the DSIL (Deutsche Studieninitiative Leukämien) Study Group. Cuplike acute myeloid leukemia: new disease or artificial phenomenon? Haematologica. 2008 Feb;93(2):283-6. DOI: 10.3324/haematol.11669

  • 4. Chen W, Rassidakis GZ, Li j, Routbort M, Jones D, Kantarjian H et al. High frequency of NPM1 gene mutations in acute myeloid leukemia with proeminent nuclear invaginations(„cuplike nuclei”). Blood. 2006 Sep;108(5):1783-4. DOI: 10.1182/ blood-2006-03-014340

  • 5. Park BG, Chi HS, Jung S, Park CJ, Kim DY, Lee JH et al. Association of cup-like nuclei in blasts with FLT3 and NPM1 mutation in acute myeloid leukemia. Ann Hematol. 2013 Apr;92(4):451-7. DOI: 10.1007/ s00277-012-1645-5

  • 6. Vardiman J, Thiele J, Arber D, Brunning R, Borowitz M, PorwitA et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and importantchanges. Blood. 2009;114(5):937-51. DOI: 10.1182/ blood-2009-03-209262

  • 7. Schnittger S, Schoch C, Kern W, Mecucci C, Tschulik C, Martelli MF, et al. Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood. 2005 Dec;106(12):3733-9. DOI: 10.1182/ blood-2005-06-2248

  • 8. Verhaak RG, Goudswaard CS, van Putten W, Bijl MA, Sanders MA, Hugens W et al. Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood. 2005 Dec;106(12):3747-54. DOI: 10.1182/ blood-2005-05-2168 9 Thiede C, Koch S, Creutzig E, Steudel C, Illmer T, Schaich M et al. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood. 2006 May;107(10):4011-20. DOI: 10.1182/blood-2005-08-3167

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