Serological, clinical and epidemiological aspects of Lyme borreliosis in Mures County, Romania

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Abstract

Lyme borreliosis (LB) is the most frequent infection transmitted by ticks from the Ixodes genus, both in the United States of America (USA), and in Europe. The objectives of this study were the monitoring of the incidence and clinical manifestations of the disease in Mures County, Romania. Material and method. The study was conducted over a period of two years, January 1st 2010 -December 31st 2011, on a number of 120 consecutive patients. The definite or probable diagnosis of LB was established on the Centers for Disease Control and Prevention (CDC, Atlanta, USA) criteria, and on the European Union Concerted Action on Lyme borreliosis (EUCALB). ELISA and Western-Blot techniques were used for identification of IgM and IgG antiBb from the serum and CSF. Results. There were 44 cases in 2010 and 76 cases in 2011. According to the case definition, 106 cases were confirmed as LB and 14 were probable. LB was more frequently diagnosed in children, young adults and adults, compared to the over 60 years old age group. The incidence of disease was higher in women patients, 68 (56.66%) compared to men - 52 patients (43.33%), with a higher proportion in people coming from an urban setting, 78 patients (65%), compared to people coming from rural settings 42 patients (35%). Clinical manifestations were acute, like erythema migrans (EM) in 64.16% of the patients, neurological in 22.5% of the patients, joint related in 1.66% of the patients and cardiac in 0.83% of the cases. Conclusions. In Mures County we have observed an increased incidence of this disease in 2011 vs. 2010. The predominant clinical manifestations were the acute dermatological and neurological ones.

Rezumat

Borrelioza Lyme (BL) este cea mai frecventă infecţie transmisă de căpuşe din genul Ixodes, atât în Statele Unite ale Americii (SUA), cât şi în Europa. Obiectivele studiului au constat în monitorizarea incidenţei şi a manifestărilor clinice ale bolii în judeţul Mureș. Material şi metodă. Studiul s-a efectuat pe o perioadă de 2 ani, 1 ianuarie 2010 - 31 decembrie 2011, pe un număr de 120 pacienţi. Diagnosticul cert sau probabil al BL s-a stabilit pe baza criteriilorCenters for Diseases Control and Prevention (CDC, Atlanta, SUA) şi European Union Concerted Action on Lyme Borreliosis (EUCALB) şi anume epidemiologice, clinice şi serologice. Pentru identificarea anticorpilor antiBb IgM, IgG din ser şi LCR s-au utilizat tehnicile ELISA şi Western-Blot. Rezultate. În anul 2010 s-au înregistrat 44 cazuri, iar în anul 2011, 76 cazuri. Conform definiţiei de caz, 106 cazuri au fost confirmate, 14 probabile. BL a fost evidenţiată cu o frecvenţă mai ridicată la copii, adulţi tineri şi adulţi, comparativ cu grupa de vârstă peste 60 ani. Incidenţa afecţiunii a fost mai ridicată la sexul feminin, 68 pacienţi (56,66%) faţă de sexul masculin 52 pacienţi (43,33%), cu o pondere, mai crescută la persoanele din mediul urban, 78 pacienţi (65,0%), comparativ cu cele din mediul rural 42 pacienţi (35,0%). Manifestările clinice au fost acute de tipul eritemului migrator (EM) la 64,16 din pacienţi, neurologice la 22,50% pacienţi, articulare la 1,66% pacienţi şi cardiace la 0,83% din cazuri. Concluzii. În judetul Mureș s-a constatat o incidenţă în creştere a bolii în anul 2011 comparativ cu anul 2010. Manifestările clinice predominante au fost cele acute dermatologice, neurologice.

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Revista Romana de Medicina de Laborator

Romanian Journal of Laboratory Medicine

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IMPACT FACTOR 2016: 0.325

CiteScore 2016: 0.25

SCImago Journal Rank (SJR) 2016: 0.143
Source Normalized Impact per Paper (SNIP) 2016: 0.145

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